The construction of advanced manufacturing base in Guangdong-Hong Kong-Macao Greater Bay Area is of great demonstration significance for the strategic adjustment of China's manufacturing transformation and upgrading. This paper constructs an evaluation system of advanced manufacturing capability. Then, we analyzes the comparative analysis of the selected city. It is found that the 9 cities, on the whole, have a good industrial foundation, but the 9 cities also have bottlenecks, such as the lack of advanced manufacturing industry development momentum, core technology and talent, development atmosphere and industry standards. In addition, this paper utilizes life cycle theory to measure the stage of advanced manufacturing industry in 9 cities, and puts forward four modes according to different development stages, including industrial coordination mode, technological innovation mode, industrial integration mode and basic development mode. Finally, from the government, enterprises and universities aspects, this paper to provide recommendations for the development of advanced manufacturing industry, including attach importance to scientific research innovation, industrial structure, high-tech.