According to the demand of new infrastructure construction, there is a huge gap of talents in our country, especially for the interdisciplinary talents with comprehensive innovation ability. At present, cross-disciplines has become an important path of scientific and technological innovation, a key drive for industrial upgrading, and an effective guarantee for the development of national strength. With the analysis of interdisciplinary talents cultivation at home and abroad, it is found that the limiting factors mainly include old traditional ideas, inflexible cultivate mechanism, unclear objective, and inadequate training system. University S&T think-tank has several natural features such as cross disciplines, cross institutions, and cross training steps. Based on the experience from discipline construction of intelligent unmanned system science and technology in Northwestern Polytechnical University, it is suggested that university S&T think-tank should make the best use of its foresight and integrity, pay more attention on professionalism and innovativeness, keep enhancing its continuity and leading, so as to better support new infrastructure construction.