米非司酮加丙酸睾丸酮配伍米索前列醇终止12～16周妊娠的临床观察

终止 12～ 16周妊娠手术风险大、并发症多 ,给受术者带来较大痛苦。为此 ,我院自 1999年开展了米非司酮加丙酸睾酮配伍米索前列醇终止 12～ 16周妊娠 ,现将结果报导如下。1　对象与方法1 1　对象　 2 0 0 1年 1月～ 2 0 0 2年 6月我院孕 12～16周 ,要求终止妊娠的健康妇女 12 2例 ,年龄 18～ 4 5岁 ,Ｂ超提示孕 2～ 16周 ,无米非司酮及米索前列醇禁忌证 ,随机分时两组 ,Ａ组 39人 ,Ｂ组6 3人。1 2　方法　Ａ组口服米非司酮 10 0ｍｇ ,上午 9时口服 ,连服 2天 ,服药前后 2小时空服 ,用温开水送服 ,于第 3天早上 7时将米索前列醇 0 6ｍｇ放入…     

米非司酮配伍米索前列醇治疗疤痕性子宫早孕疗效及安全性观察

目的探讨米非司酮配伍米索前列醇用于终止停经≤49d瘢痕子宫的妊娠。方法晨起空腹服米非司酮75mg,用药第2天早晨空腹服米非司酮75mg;用药第3天来我院空腹口服米索前列醇600μg(3片,200μg/片)门诊观察6h。结论:米非司酮结合米索前列醇用于早孕瘢痕子宫终止妊娠安全有效,值得应用与推广。     

米非司酮配伍米索前列醇终止11～16周妊娠126例临床观察

早中期妊娠126例，连续两晚睡前顿服米非司酮（Ru486）75mg，第三日晨空腹口服米索前列醇600цg，6小时内胎儿或胎儿、胎盘自行流产者95例，钳刮31例，无一例发生大出血、感染及损伤。米非司酮配伍米索前列醇对早中期妊娠有良好的流产效果。     

米非司酮配伍米索用于足月妊娠引产临床分析

目的探讨米非司酮配伍米索前列醇在足月妊娠引产的作用和安全性 ;方法将 6 2例足月妊娠的正常孕妇有引产指征者随机分成两组进行比较。研究组 (31例 )口服米非司酮 2 0 0mg及米索前列醇5 0ug阴道上药 ,每二小时一次至正式临产 ;对照组 (31例 )口服蓖麻油 5 0毫升炒鸡蛋 2个一顿用。结果两组引产总有效率分别为 93.5 %和 75 .1% ,有显著性差异 (P <0 .0 1)。结论应用米非司酮配伍米索前列醇进行足月妊娠引产 ,能促宫颈成熟 ,发动子宫收缩 ,并安全、有效、方便、有临床价值。     

加量米非司酮伍米索前列醇用于中期妊娠引产的临床研究

米非司酮伍米索前列醇终止早孕已被证实相当安全、有效 ,完全流产率 >95% ,常规用药量为米非司酮 2 5ｍｇ ,每 12ｈ一次 ,三天后加服米索前列醇6 0 0ｍｇ ,无效者刮宫处理。而对中期妊娠引产则多使用钳刮 ,利凡诺引产等处理 ,受术者痛苦大 ,并发症较多 ,探讨用药物终止中妊娠的可能性 ,有效性及安全性 ,我们尝试用加量米非司酮伍米索前列醇终止10— 18周中期妊娠 ,取得较满意的效果 ,现报告如下 :1　资料和方法1.1　对象选择　 1996年 12月到 1999年 6月在我院就诊的患者 186例 ,年龄 2 0— 34周岁 ,身体健康 ,停经 10— 18周 ,经妇科检查 ,…     

米非司酮配伍利凡诺终止中期妊娠的临床观察

目的:探讨终止14～20周妊娠的最佳方法.方法:把孕14～20周要求终止妊娠的健康孕妇随机分为两组,对照组直接羊膜腔内注射利凡诺100 mg,研究组分次口服完200 mg米非司酮后再行羊膜腔内注射.并观察进入产程时间、总产程时间、产后出血量、子宫持续出血时间、胎盘胎膜残留率、清宫率、引产成功率等.结果:研究组比对照组进入产程快,总产程短,产后出血量少,子宫持续出血时间短,胎盘胎膜残留少,清宫率低,差异有显著性.引产成功率差异无显著性.结论:米非司酮配伍利凡诺终止中期妊娠优于单纯使用利凡诺引产,方法简单可行.值得临床推广.     

药物终止早孕的临床超声观察

利用药物米非司酮配伍米索前列醇终止早孕疗效明确,并且安全有效,但利用超声对其用药前后观察,更能有效的提高其成功率,指导临床。 1 临床资料 1.1 一般资料 2000.1～2001.1月来我院就诊的52例病例,年龄20～40岁,其中20例为第一次怀孕,32例为避孕失败再次怀孕,尿HCG试验阳性。 1.2 用药方法 药品为北京第三药厂生产,口服米非司酮25mg,每12h一次共3d,第四天一次顿服米索前列醇600ug。用药前常规B超,以排除宫外孕及其它     

米索前列醇在足月妊娠引产中的应用

我院自1999年1～12月,对120例足月妊娠和过期妊娠二周之内的孕妇,采用阴道放置米索前列醇(简称米索)和口服米索对其有效性和安全性进行临床观察,它与催产素相比则使用方法简单,效果好,因此近年中米索的应用得到了迅速的推广,在文中重点介绍本药的使用方法以及副作用、并发症。1 临床资料1.1 一般资料 我院1999年1月到12月住院分娩800例,观察了120例,孕周大于38周-42周之内者,单胎头位正常待产孕妇,无明     

米非司酮并冰水囊及米索前列醇终止中期妊娠临床分析

目的:观察分析米非司酮并冰水囊和米索前列醇用于中期妊娠引产之效果与副反应。方法:米非司酮25mg,每日早6点服药,2h后进食,晚饭后2h服药,连服三天后行冰水囊引产。24h取出水囊未分娩者后穹窿放入米索前列醇0.2mg,并与雷凡诺羊膜腔内引产对照。结果:米非司酮并冰水囊引产一次成功率100％。79％24h内自然分娩,21％后穹窿放米索前列醇后分娩。米非司酮组宫缩开始时间平均为2.5h,雷凡诺平均为6(4/15)h,总平均时间分别为20(1/6)、40(1/3)h,产后出血平均分别为80.6ml,120.2ml,胎盘胎膜残留刮宫者6％、84％,米非司酮组服药后12％有轻微恶心,雷凡诺40％有低烧,分娩后好转。结论:米非司酮并冰水囊引产必要时加米索前列醇缩短了产程,减少并发症,提高了引产率,为安全、有效的方法之一。     

米非司酮配伍依吖沙啶用于大月份引产临床观察

目的:探讨术前用米非司酮,乙烯雌酚对依沙吖啶中期妊娠引产的临床效果影响,以减少引产并发症.方法:将150例要求中期妊娠引产的健康妇女随机分为3组,其中Ⅰ组50例,单纯用依沙吖啶引产;Ⅱ组50例,口服米非司酮50mg,bid×2d,第三日行依沙吖啶引产术;Ⅲ组50例,肌注乙烯雌2mg,bid×2d,第3天行依沙吖啶引产术.结果:米非司酮对宫颈的质地、颈管长度和宫口位置有明显的作用,对宫颈有软化和扩张的作用;米非司酮组平均引产时间(注药至分娩时间)为30.80±7.55h,与乙烯雌酚组和对照组比较,有显著性差异(P＜0.001);结论:米非司酮作为依沙吖啶中期妊娠引产的术前用药,能明显提高引产的有效性,减少引产并发症发生.     

植入性胎盘保守治疗10例体会

目的运用甲氨蝶呤、米非司酮及中药保守治疗,观察非手术治疗植入性胎盘的疗效。方法米非司酮50mg口服,2次/d,共服5d;甲氨蝶呤20mg,1次/d,肌肉注射,连用3d;5天后口服中药生化汤加味。结果 10例植入性胎盘患者住院7～24d,均痊愈出院。结论保守治疗对植入性胎盘是可行的。     

米非司酮25mg用于紧急避孕156例观察

目的:了解在无保护性交后72h内应用小剂量米非司酮紧急避孕的临床效果、副反应及对月经的影响。方法:将无保护性交后72h内的156例妇女给予单次口服25mg米非司酮,观察其避孕效率,用Dixon方法计算有效率。结果:1例因方法失败,156例妇女预期总妊娠数为10.188例,实际妊娠数为1例,避孕有效率为90.18％,服药后出血发生率为10.3％,与上海协作组比较P>0.05。结论用25mg米非司酮作为紧急避孕无严重副反应,对月经周期无明显于扰。     

头孢匹胺治疗下呼吸道感染72例临床观察

将72例确诊为下呼吸道感染的患者随机分成2组,在常规治疗基础上,治疗组36例,静脉滴注头孢匹胺1g,每日两次;对照组36例静脉滴注头孢尼西2g,每日一次,两组疗程均为7～14天,观察两组的临床疗效.治疗组和对照组临床治愈率分别是94%和83%,总有效率分别为97%和88%,两组数据比较有统计学意义(P<0.05).结果表明头孢匹胺是第三代头孢菌素,安全抗菌活性强.在下呼吸道感染的治疗中疗效确切.     

Moderate Alcohol Consumption and Psychological Stress during Pregnancy Induce Attention and Neuromotor Impairments in Primate Infants

This study examined the effect of moderate alcohol and/or psychological stress during prenancy on off-spring growth and behavior in 33 rhesus monkey infants ( Macaca mulatta ). Infants were derived from 1 of 3 groups of female: (1) alcohol-consuming,0.6g/Kg, Daily throughou gestation (equivalet, to 1-2 drinks), beginning 5 day prior to breeding;(2) alcohol-consuming (as above) and exposed to mild psychological stress(removal from home cage and exposed to 3 random noise bursts); (3) sucrose-consuming, equivolemic, and equicaloric to the alcohol solution.Beginning on day 4 postpartum, intantrs underwent brief weekly separations from their mother for assessment of growth, behavior, and facial dimensions. Results indicated that moderate alcohol consumption throughout pregnancy was sufficient to affect attention and neuromotor functioning, even though the infants were normol in birthweight, gestational length, and facial dimensions, Moreover, alcohol-induced neuromotor impairments were exacerbated by maternal exposure to psychological stress, and males from the alcohol/stress condition had reduced birthweights. Finally, although all females consuming alcohol produced viable offspring, alcohol accompanie by stress during gestation resulted in 23% fetal losses (abortion and stillbirths).     

小鼠肠道菌群失调动物模型的制备

用乳糖酸红霉素（2．94g／kg）、头孢氨苄（6．19g／kg）、盐酸林可霉素（2．02g／kg）、氨苄西林钠（5．5g／kg）,3次／天,连续10天灌服小鼠,分别于灌服后第2d、4d、6d、8d、10d、12d、14d、16d对直肠和盲肠粪便中杆菌和球菌的菌落数进行测定。结果表明：灌服抗生素后杆菌菌落数量减少,球菌菌落数量增加,取代杆菌成为直肠和盲肠中的优势菌群;停药后第6d,除盐酸林可霉素组外,其它灌服组杆菌和球菌数量均可逐渐恢复。结论：乳糖酸红霉素、头孢氨苄、盐酸林可霉素及氨苄西林钠均能导致小鼠肠道菌群失调,其中盐酸林可霉素对肠道杆菌的抑制作用较明显,诱导效果较稳定和持久。     

THE IMPROVEMENT OF VERBAL FLUENCY IN THE ELDERLY: THE EFFECTS OF PRACTICE ON THE SET TEST AND AN ALTERNATE FORM

The effects of prior practice on the Set Test (ST), a test of verbal fluency, were examined in a group of 30 relatively able patients aged 62‐94 in a continuing care geriatric ward. Subjects were randomly assigned to one of three groups, a specific prior practice group (ST on Day 1 and again 24 hours later), a nonspecific prior practice group (an alternate form of the ST on Day 1, ST 24 hours later) and a control group (conversation on Day 1, ST 24 hours later). Analysis of ST performance showed no significant difference between the two experimental groups and the control group on day 2, but significant improvements for the two groups from days 1 to 2. The clinical implications of this finding are discussed. Analysis of the psychometric characteristics of the ST and the alternate form showed the tests to have high internal consistency and reliability, although further data are needed before the two forms are regarded as parallel.     

早期饲喂对肉鸡生长性能和肠道消化酶的影响

为研究早期饲喂对肉鸡生长性能和肠道消化酶的影响,选择360只刚出壳的AA肉用雏鸡,采用单因子试验设计,随机分成4个处理组,每组4个重复,每个重复20只,试验1组出壳后12 h饲喂,试验Ⅱ组出壳24 h后饲喂,试验Ⅲ组出壳36 h后饲喂,对照组出壳48 h后饲喂.饲喂相同日粮,试验期为6周.于21日龄和42日龄分别测定肉鸡进行生产性能和酶活性.结果表明：早期饲喂显著提高了肉鸡的日增重,降低了料重比,试验Ⅰ组和试验Ⅱ组与对照组相比,日增重分别提高了4.19%和3.70%,料重比分别降低5.61%和5.10%,差异显著（P〈0.05）;试验Ⅰ组、试验Ⅱ组和试验Ⅲ组肠道消化酶水平高于对照组.早期饲喂提高了肉鸡肠道消化酶水平,以出壳后12 h饲喂最好.     

Effectiveness of paraeducator-supplemented individual instruction: beyond basic decoding skills

A total of 46 children in Grades 2 and 3 with low word-level skills were randomly assigned to 1 of 2 groups that received supplemental phonics-based reading instruction. One group received intervention October through March (21.5 hours), and one group served as a control from October through March and later received intervention March through May (17.5 hours). Paraeducators trained in a standard treatment protocol provided individual instruction for 30 min per day, 4 days per week. At the March posttest, the early treatment (ET; n = 23) group outperformed the controls (late treatment, LT; n = 20) on reading accuracy and passage fluency. Across both groups, second graders outperformed third graders on these same measures. At the 3-month follow-up, the ET group showed no evidence of decline in reading accuracy, passage fluency, or words spelled; however, 3rd-grade ET students had significantly higher spelling skills compared to 2nd graders. The LT group demonstrated significant growth during their intervention in reading accuracy and spelling, but not passage fluency. When we compared the ET and LT groups on their gains per instructional hour, we found that the ET group made significantly greater gains than the LT group across all 3 measures. The results support the value of paraeducator-supplemented reading instruction for students below grade level in word identification and reading fluency.     

三七总皂甙对大鼠脑出血灶周围神经元Bcl-2/Bax及脑含水量变化的影响

研究大鼠脑出血给予三七总皂甙治疗后,神经元Bcl-2和Bax的表达有无变化,并观察脑出血大鼠在不同时间点相干/湿重法测定脑含水量的变化.神经行为学检测结果表明,脑出血组大鼠的神经功能评分分值升高;2d后治疗组大鼠与脑出血组相比分值下降（P＜0.01）.免疫组织化学结果显示,治疗组Bcl-2的阳性表达较脑出血组高（P＜0.01）、Bax的阳性表达较脑出血组低（P＜0.01）,Bcl-2/Bax蛋白比值增高;脑含水量即12 h开始增加,24 h后比较明显,48 h达高峰,7d之后与正常组无明显差异.三七总皂甙治疗组48 h ～72h干预后,脑含水量明显低于其脑出血组（P＜0.05）.