Lp-PLA_2与2型糖尿病合并冠心病的相关性

目的:探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA_2)与2型糖尿病(T2DM)合并冠心病(CHD)的关系。方法:T2DM合并CHD组60例,T2DM无血管并发症组50例,健康体对照组50例,评估Lp-PLA_2水平、阳性率及与疾病的相关性。结果:Lp-PLA_2水平及阳性率T2DM合并CHD组、T2DM组高于对照组,T2DM合并CHD组高于T2DM组(P均0.05)。Lp-PLA_2与T2DM合并CHD及T2DM均呈正相关关系(P0.05)。结论:T2DM合并CHD及T2DM患者Lp-PLA_2水平明显升高,Lp-PLA_2水平与T2DM合并CHD密切相关,检测Lp-PLA_2对预测T2DM合并CHD具有一定的临床价值。     

高血压合并左室肥厚的中西医防治

近年来国内的心血管病(CVD)患病人群不断扩大,高血压(HBP)是CVD中较为常见的一种慢性疾病,亦是导致心血管风险增加的危险要素之一。HBP合并左室肥厚(LVH)是心血管突发事件几率增加的单独风险因子。文章回顾及研讨中医和西医对HBP合并左室肥厚相关研究近况与成果,为以后的进一步探究提供依据。     

冠心病患者血浆同型半胱氨酸变化及叶酸的干预治疗

目的 了解血浆同型半胱氨酸(Homocysteine，Hcy)、叶酸和维生素(Vit)B12水平与冠心病的关系；观察叶酸干预治疗高Hcy血症的疗效．方法 经冠脉造影确诊的冠心病患者97例、亚冠心病患者58例及完全正常3l例，用高效液相色谱法测血浆Hcy水平，用放免法测血浆叶酸和VitB12浓度．其中高Hcy血症病人每天服用叶酸5mg，观察4周和8周后血浆Hcy水平变化．结果 冠心病和亚冠心病患者血浆Hcy水平明显高于正常人，叶酸和VitB12水平则明显下降；冠心病患者冠脉病变支数越多，血浆Hcy升高和叶酸、VitB12下降越明显；叶酸治疗高Hcy血症患者4周和8周，分别使血浆Hcy水平下降12．5％和38．5％．结论 冠心病和亚冠心病患者血浆Hcy水平明显升高，高Hcy血症是冠心病的危险因素之一．血浆Hcy水平变化与冠脉病变程度正相关．叶酸干预治疗可使高Hcy血症患者血浆Hcy浓度明显降低．     

三类高血压患者宜服阿司匹林

很多高血压患者都不拿高血压当回事,认为自己没有症状就不用治疗控制。殊不知,高血压不仅可引起严重的心、肾、脑等并发症,同时也是脑卒中(中风)和冠心病的主要危险因素。降压治疗是预防卒中和冠心病的重要措施。     

新蝶呤——冠心病活动的一个新标志

目的　为了研究冠心病发病的可能机制 ,探讨可能诊治策略 .方法　对 4 0例冠脉造影证实的冠心病患者 (2 0例急性冠脉综合征 ,2 0例稳定心绞痛 )和 16例正常人测定了血清新蝶呤水平 ,并与临床分型进行了分析 .结果　发现冠心病患者新蝶呤水平显著高于正常人 (分别为(15 .16± 7.4 4) nmol/ L和 (8.38± 4 .6 9) nmol/ L,P<0 .0 1) .急性冠脉综合征患者新蝶呤水平显著高于稳定心绞痛患者 (分别为 (17.83± 8.38) nmol/ L和 (12 .5 0± 5 .34) nmol/ L,P<0 .0 5 ) ;而稳定心绞痛患者新蝶呤水平又显著高于正常人 (分别为 (12 .5 0± 5 .34) nmol/ L和 (8.38± 4 .6 9) nmol/L,P<0 .0 5 ) .结论　冠心病 ,特别是急性冠脉综合征患者新蝶呤水平显著升高 ,免疫激活可能参与了冠心病的病理生理过程 ,新蝶呤是冠心病活动的一个重要标志     

一种采用自适应机制的分层置信传播算法

提出了一种基于迭代自适应机制的改进算法,有效地缩减了分层置信传播算法(HBP)的计算时间.传统HBP计算时间随指定的迭代上限增加而线性增长.为此引入消息收敛的条件判断,在迭代上限相同情况下,减少算法的迭代次数,缩减整体迭代时间.实验表明,与传统HBP相比,该方法计算时间缩减了38％以上,计算时间对整体迭代上限不敏感.该方法可以应用于使用HBP算法的其他方法.     

原发性高血压与高纤维蛋白原血症：（附68例分析）

本文测定了68例原发性高血压患者的血浆纤维蛋白原浓度,并与50例正常血压者作了对照,发现原发性高血压组的血浆纤维蛋白原浓度为700.3±211.4 mg/dl,比对照组高(P相似文献   

ABI与CAVI检测2型糖尿病中单纯高血压与合并冠心病患者的临床应用

目的 对2型糖尿病患者中ABI与CAVI检测在单纯高血压与合并冠心病患者的临床应用进行研究及判定。方法 选取本院2015年2月至2016年1月间2型糖尿病患者120人,其中高血压与合并冠心病患者60人,单纯高血压患者60人,并将其ABI、CAVI值进行对比,以此判定ABI、CAVI检测于单纯高血压与合并冠心病患者的临床意义。结果 2型糖尿病患者中高血压与合并冠心病患者的ABI值为(0.88±0.07),较单纯高血压组低,P0.05,其CAVI值为(9.27±1.08),高于高血压组,P0.05,其高血压组的CVAI值为(8.61±1.34)。结论 ABI、CAVI可体现心血管疾病的动脉硬化程度,临床中可依据其ABI、CAVI值采取优质的治疗,以此促进患者的病情康复,值得在临床中推广实施。     

拉萨某社区世居居民高血压合并肥胖的分布特征及分析

目的了解拉萨某社区世居居民高血压合并肥胖检出情况及特征,为该社区居民高血压合并肥胖的早期防治提供有效数据支持。方法纳入于2017年5—6月期间体检的社区居民共946人为研究对象,年龄为(30～80)岁,测量身高、体重和血压,做血常规、生化指标和腹部B超检查。用SPSS26.0软件分析数据。结果高血压合并肥胖者156人(16.5%),男性67人(19.7%),女性89人(14.7%)。高血压合并肥胖组的脂肪肝(63.5%)、红细胞增多(20.5%)、血红蛋白增多(42.9%)、谷丙转氨酶升高(50.6%)、胆固醇升高(34.0%)、甘油三酯升高(31.4%)和高尿酸血症(21.2%)的检出率均高于健康组的脂肪肝(7.6%)、红细胞增多(8.6%)、血红蛋白增多(16.2%)、谷丙转氨酶升高(22.3%)、胆固醇升高(13.2%)、甘油三酯升高(9.1%)和高尿酸血症(5.1%),这些差异均存在统计学意义(χ~2=124.19、10.28、30.77、30.73、21.63、28.09和21.04,均P0.05)。进行多因素logisitic分析,结果提示脂肪肝(OR(95%CI)为16.54(8.75～31.25),P0.001)、血红蛋白增多(OR(95%CI)为2.70(1.47～4.95),P=0.001)和甘油三酯升高(OR(95%CI)为3.18(1.55～6.52),P=0.002)均与高血压合并肥胖的发生正相关。结论该社区世居居民高血压合并肥胖的检出率较高。     

冠脉支架植入术后支架内再狭窄的危险因素分析

目的：：分析冠状动脉支架植入术后支架内再狭窄的危险因素和提出管理方法。方法对2006年1月1日至2006年12月31日在我院冠心病行冠状动脉支架植入术后行冠状动脉造影随访的126例资料进行了回顾性分析。结果：A组患者在吸烟(>20支)(24.32%)、高血压(72.97%)、糖尿病血(35.14%)、血尿酸(410.89±80.11)μmol/L、血清总胆红素(11.45±3.98)μmol/L、直径长度(31.09±3.32)mm、直径(2.88±0.28)mm与B组比较,差异有统计学意义(P<0.05)。结论：冠状动脉支架植入患者出现再狭窄危险是由很多因素造成的,所以我们要找出此类情况出现的原因和采用相应的管理以及预防措施。     

冠心病患者和正常人血脂与心率变异性频域指标关系的研究

目的：分析冠心病患者和正常人血脂水平与心率变异频域指标及自主神经活动的关系。方法：对71例确诊的冠心病患者和96例正常人行24h动态心电图并采空腹血查血脂，分别比较两类人群中高胆固醇血症组与正常胆固醇组心率变异频域指标VLF、LF、HF、LF／HF的差异，并用多元逐步回归分析血脂各值与心率变异的相关性。结果：高胆固醇血症组与正常胆固醇组相比，冠心病患者中HF值显著降低（P＜0．05），而LF／HF值显著增高（P＜0．01）；正常人亦有高胆固醇血症组HF值较低而F/HF值较高的趋势，但无统计学差异。多元逐步回归分析中，冠心病患者HF与TC呈负相关，LF／HF则与TC、LDL呈正相关；正常人中LF／HF亦与TC呈正相关。结论：冠心病患者和正常人中血脂水平均与心率变异及自主神经活动存在一定的相关性。胆固醇增高者交感与迷走神经平衡性失调，交感神经活性相对较高而迷走神经活性相对较低。     

血浆纤维蛋白原含量升高与冠心病

用盐析－双缩脲法对９７例健康人和７９例冠心病患者进行了血浆纤维蛋白原含量的测定，结果表明：冠心病患者血浆纤维蛋白原含量显著高于健康人（Ｐ＜０．０１），提示纤维蛋白原含量升高是冠心病、中风、血栓形成的一种重要的危险因素．对血浆纤维蛋白原进行检测，将为冠心病的临床诊断及预防提供依据     

Risk prediction—Homocysteine in Coronary Heart Disease

Majority of patients who experience a Coronary Heart disease event have one or more of the conventional risk factors for atherosclerosis and so do many people who have not yet experienced such an event. Thus predictive models based on conventional risk factors have lower than the desired accuracy, providing a stimulus to search for new factors to predict accurately the risk of CHD. In this regard newer risk factors like homocysteine, Lp(a), insulin resistances are the important ones and are called as ‘novel risk factors’. The study was undertaken to find the prediction of CHD risk by homocysteine in comparison with other conventional risk factors. The data obtained suggests a very high sensitivity, specificity and accuracy with above 90% positive prediction value for homocysteine in CHD patients when compared to commonest conventional risk factors.     

冠心病患者血浆内皮素含量测定

为探讨血浆内皮素对冠心病患者的意义,采用放射免疫分析法对４９例健康人与２０例冠心病患者进行血浆内皮素含量测定。结果表明冠心病患者血浆内皮素含量明显高于健康人,差异非常显著,Ｐ〈０．０１,说明血浆内皮素含量升高对冠心病的发生和发展具有重要作用。     

Inflammatory Cytokines,Apoptotic, Tissue Injury and Remodeling Biomarkers in Children with Congenital Heart Disease

The present study aims to evaluate specific biomarkers involved in congenital heart disease (CHD), and whether there is a significant differences between the levels of these biomarkers in the cyanotic CHD (CCHD) and acyanotic CHD (ACHD). We prospectively measured tumor necrosis factor (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), vasoendothelial growth factor (VEGF), troponin T, creatin kinase MB (CKMB), and Caspase 3 levels in 120 consecutive children with CHD (60 cyanotic and 60 a cyanotic with age 1:4 years), and 30 healthy control children. Significant elevated levels of inflammatory markers; TNF-α, IL-6 and CRP was detected in CHD, with percentage increase in cyanotic than a cyanotic subjects as compared to the normal one. Apoptotic biomarker; caspase 3 showed also significant increases in CCHD than ACHD. In addition, tissue injury mechanisms included troponin T and CKMB, exhibited significant increase in cyanotic than a cyanotic CHD. The present results demonstrate also, significant enhancement in remodeling process (VEGF), in cyanotic than a cyanotic patients. Thus, it could be concluded that, the children with CCHD were shown to have elevated levels of inflammatory cytokines, caspase 3, troponin T, and CKMB as these biomarkers may implicated in cardiac functional status.     

Lipoprotein (A): Better assessor of coronary heart disease risk in south Indian population

In an attempt to search for risk factors which can explain the increasing prevalence of coronary heart disease (CHD) in Indian population, we conducted a case-control study to assess the association of Lipoprotein (a)(Lp(a)) with CHD. One hundred and fifty one consecutive patients with clinical and angiographic evidence of CHD and forty-nine healthy controls were drawn for the study. Triglycerides, very low density cholesterol (VLDL-C), total cholesterol (total-C)/high density cholesterol (HDL-C) ratio, low density cholesterol (LDL-C)/HDL cholesterol ratio and Lp(a) were found to be higher in patients than controls. In female sex and in those with family history of CHD, higher total and LDL cholesterol levels were observed to be associated with higher Lp(a) levels. Lp(a) levels were also found to be higher in triple vessel disease than other vessel disease patients. Significant difference in Lp(a) levels were observed between normal coronaries vs. single and triple vessel disease(P<0.05) and also between single vs. double and triple vessel disease (P<0.01).Lp(a) levels correlated positively with vessel severity(P<0.005). Lp(a) levels >25 mg/dl were associated with coronary heart disease (Odds ratio 1.98 P<0.05 95% CI 0.007–1.18). Our findings suggest a cut-off level of 25mg/dl for determination of risk of CHD. Studies from different areas involving larger sample size are needed to confirm the findings of the present study.     

Study of Common Genetic Variant S447X in Lipoprotein Lipase and Its Association with Lipids and Lipoproteins in Type 2 Diabetic Patients

Elevated plasma triglyceride and non-esterified fatty acid concentrations may cause insulin resistance and type 2 diabetes mellitus. Lipoprotein lipase (LPL) is a rate-determining enzyme in lipid metabolism. A variant in the LPL gene has been identified which alters the penultimate amino acid Serine at 447 to a stop codon (S447X), and results in a truncated LPL molecule lacking the C-terminal dipeptide Ser–Gly. The present study was designed to evaluate the frequency of S447X variant in the LPL gene and its effect on the lipid and lipoprotein levels in type 2 diabetic subjects. The genotype frequency distributions of type 2 diabetes patients and controls were in Hardy–Weinberg equilibrium. Comparison of the genotype and allelic frequencies of S447X in subjects with type 2 diabetics compared to controls demonstrated no significant difference. In subjects with type 2 diabetics having hypertriglyceridemia (TG ≥ 150 mg/dl) compared to diabetics with TG level <150 mg/dl, significant difference in genotype frequency was found among these groups, while allelic frequency of X was significantly differed. Logistic regression analysis showed the negative association of LPL S447X variant with TG and VLDL cholesterol, while no association with total cholesterol, HDL cholesterol and LDL cholesterol was found. The lipid levels except for HDL cholesterol were found to be significantly lower in carriers for S447X than wild type in diabetes group. The decreased level of TG and TG rich lipoprotein in subjects with SNP S447X in LPL, predicts anti-atherogenic activity of carriers for S447X variant in general population as well as type 2 diabetic patients.     

阻燃型醋酸乙烯酯共聚乳液的制备及阻燃性能研究

以聚磷酸铵和季戊四醇复配对丙烯酸丁酯—醋酸乙烯酯共聚乳液进行阻燃研究.通过极限氧指数(LOI)、垂直燃烧和热重分析等手段,对材料的燃烧性能以及热降解行为进行研究,采用扫描电镜对碳层结构进行表征.最佳LOI值可达28.9,并通过垂直燃烧V-0级别;同时,高温阶段碳层重量得到明显提高,且结构稳定.     

Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects

Apolipoprotein E genotypes and lipid and lipoprotein levels were determined in hypercholesterolemic and angiographically vertified CHD subjects and compared against 90 normolipidemic controls. The ε4 allele was significantly prevalent in the hypercholesterolemic and CHD subjects. Significant increase in total cholesterol levels in apo ε4 containing subjects were observed in the hypercholesterolemic and CHD group. The study suggests that the ε4 allele by influencing the lipid levels could act as a risk factor for CHD.     

力平脂调血脂作用的临床观察：附68例临床分析

观察了力平脂对高脂血症者的治疗作用和安全性．确诊高脂血症者６８例，力平脂，０．１，Ｔｉｄ，服一个月为一疗程后，血清总胆固醇（ＴＣ）平均降低２０．９８％，甘油三酯平均降低５１．８８％，ＨＤＬ－Ｃ平均升高１０．２６％，ＬＤＬ－Ｃ平均降低１２．５７％，ＡｐｏＡ１平均升高２．２４％，ＡｐｏＢ平均降低２１．１０％，从调血脂的个体疗效分析，力平脂降低ＴＣ的总有效率８４．６１％，降低ＴＧ的总有效率９５．２４％，升高ＨＤＬ－Ｃ的总有效率６１．７７％，降低ＬＤＬ－Ｃ的总有效率为５５．８８％，升高ＡｐｏＡ１的总有效率３８．２４％，降低ＡｐｏＢ的总有效率７７．９４％．提示：力平脂治疗高脂血症者，对降低ＴＣ，ＴＧ，ＬＤＬ－Ｃ，ＡｐｏＢ和升高ＨＤＬ－Ｃ，ＡｐｏＡ１均有明显效果，其中降低ＴＧ的疗效尤为突出，副作用轻微．临床实践表明：力平脂是一个疗效高、安全、服用方便的调血脂新药