HER-2 overexpression and survival in colorectal cancer: a meta-analysis

Objective

Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value.

Methods

Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival.

Results

Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77–1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50–1.29; HR=0.90, 95% CI: 0.43–1.37, respectively).

Conclusions

Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival.     

体力活动对痴呆患者认知功能干预效果的Meta分析

目的:系统评价体力活动对痴呆患者认知功能的干预效果。方法:计算机检索PubMed、Web of Science、The Cochrane Library、EMbase、Medline、CBM、CNKI、VIP和Wan Fang Data数据库中有关体力活动对痴呆患者认知功能的随机对照试验(RCTs),检索时限均从各个数据库收录起始年限至2018年7月27日,使用PEDro量表进行方法学质量评价,采用Revman5.3软件进行Meta分析,采用Stata14.0软件进行发表偏倚检验。结果:共纳入24个RCT,包括1581例痴呆患者。Meta分析结果显示:体力活动对痴呆患者整体认知功能(MD=2.17,95%CI:1.50,2.84,P<0.00001)有积极的影响。亚组分析结果显示:体力活动对AD患者(MD=2.40,95%CI:1.58,3.23,P<0.00001)与合并AD患者(MD=1.45,95%CI:0.41,2.48,P=0.006)的整体认知功能优于对照组;有氧运动(MD=2.43,95%CI:1.63,3.23,P<0.00001)与混合运动(MD=1.48,95%CI:0.08,2.87,P=0.04)对痴呆患者整体认知功能优于对照组,但抗阻运动(MD=1.70,95%CI:-0.15,3.55,P=0.07)与太极拳运动(MD=0.92,95%CI:-2.98,4.82,P=0.64)与对照组差异无统计学意义;高频率体力活动(MD=1.64,95%CI:0.25,3.04,P=0.02)与低频率体力活动(MD=2.33,95%CI:1.57,3.09,P<0.00001)对痴呆患者的整体认知功能均优于对照组。不同认知领域Meta分析结果显示:体力活动对痴呆患者执行功能(SMD=0.08,95%CI:-0.05,0.20,P=0.22)、TMT-A与TMT-B(SMD=-0.05,95%CI:-0.26,0.16,P=0.63)和记忆功能(SMD=0.15,95%CI:-0.06,0.37,P=0.17)与对照组相比差异无统计学意义,只有注意力(SMD=0.18,95%CI:0.02,0.35,P=0.03)优于对照组。结论:体力活动干预对AD患者与合并AD患者的整体认知功能有积极影响,并且有氧与混合、高频率与低频率的体力活动干预对所有痴呆患者的整体认知功能同样有效,不同认知领域中只有注意力有改善效果。     

XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies

Objective: XRCC1 polymorphism is a research hotpot in individual treatment for non-small cell lung cancer (NSCLC). To obtain the association between XRCC1 polymorphism and clinical outcome of platinum-based treatment for NSCLC, a meta-analysis was conducted. Methods: Databases including PubMed, Embase, Cochrane, and Chinese National Knowledge Infrastructure (CNKI) were searched for publications that met the inclusion criteria. A fixed effect model was used to estimate pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) for the association between XRCC1 Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC. A chi-squared-based Q-test was used to test the heterogeneity hypothesis. Egger’s test was used to check publication bias. Results: Seventeen published case-control studies that focus on the association between XRCC1 Arg399Gln and response or survival of platinum-based treatment for advanced NSCLC in 2 256 subjects were included in this meta-analysis, of whom 522 were AA genotypes (23.2% frequency), 916 AG genotypes (40.6% frequency), and 818 GG genotypes (36.2% frequency). The overall response rate (ORR) was 45.2% (110/243) for AA genotype patients, 29.9% for AG genotype (73/244), and 30.7% for GG genotype (124/403). The heterogeneity test did not show any heterogeneity and the Egger’s test did not reveal an obvious publication bias among the included studies. The meta-analysis indicated that AA genotype patients presented higher response rates toward platinum drug treatment compared with G model (GG+GA) patients (GG vs. AA model: OR=0.489, 95% CI 0.266–0.900, P=0.021; AG vs. AA model: OR=0.608, 95% CI 0.392–0.941, P=0.026; GA+AA vs. GG model: OR=1.259, 95% CI 0.931–1.701, P=0.135; GG+GA vs. AA model: OR=0.455, 95% CI 0.313–0.663, P=0.0001). However, no evidence validates XRCC1 associates with the survival following platinum drug therapy. Conclusions: Our meta-analysis suggested that XRCC1 Arg399Gln is related with the sensitivity of NSCLC patients to platinum-based treatment. AA genotype patients present more desirable curative effectiveness compared with other patients.     

多媒体学习中视觉情绪设计对学习效果的影响——基于31项实验与准实验研究的元分析

随着信息技术的发展,多媒体与网络化教学成为现代教育的主流。多媒体教学中学习材料的情绪因素受到研究者越来越多的关注。国内外学者已开展了大量实验与准实验研究,探索在使用颜色、形状、拟人化等多种视觉元素设计的学习材料中,视觉情绪因素对学习者学习效果的影响,结论尚存争议。研究采用元分析方法,对二十年来国内外有关视觉情绪设计影响学习效果的31篇文献进行梳理与分析,并进一步从学习材料呈现步调、学习者学段和实验时长三个调节变量的影响维度进行深入探讨。研究发现:整体而言,视觉情绪设计能够促进反映学习者学习效果的保持成绩、理解成绩和迁移成绩的提高;不同呈现步调、学习者学段和实验时长对学习者学习效果的调节作用组间差异不显著。研究得到的启示:多媒体学习材料中使用饱和、高亮暖色、图片及拟人化设计,对于多媒体学习认知过程和学习效果有益。最后,在深入阅读文献的基础上,指出多媒体学习情绪设计研究中存在的问题及进一步研究的方向。     

Components of fostering self-regulated learning among students. A meta-analysis on intervention studies at primary and secondary school level

Due to new standards in fostering life-long learning at school, research has increasingly dealt with the promotion of self-regulated learning, resulting in a large number of intervention studies conducted at primary and secondary school. The current study aimed at investigating the impact of various training characteristics on the training outcomes, regarding academic performance, strategy use and motivation of students. Two meta-analyses were conducted separately, one for primary and one for secondary school level to allow for comparisons between both school levels. The meta-analyses included 49 studies conducted with primary school students and 35 studies conducted with secondary school students; analyzing 357 effect sizes altogether. The potential effects of training characteristics were investigated by means of meta-analytic multiple regression analyses. The average effect size was 0.69. For both school levels, effect sizes were higher when the training was conducted by researchers instead of regular teachers. Moreover, interventions attained higher effects when conducted in the scope of mathematics than in reading/writing or other subjects. Self-regulated learning can be fostered effectively at both primary and secondary school level. However, the theoretical background on which the training programme is based, as well as the type of instructed strategy led to differential effects at both school levels.

Social–Sexual Interactions? Meta-Analyses of Sex Differences in Perceptions of Flirtatiousness,Seductiveness, and Promiscuousness

Scholars have assessed the degree to which heterosexual men and women make differential judgments of flirtatiousness, seductiveness, and promiscuousness during cross-sex interactions. Findings from extant research suggest that men decode verbal and nonverbal communication cues differently than do women, and this difference results in men's tendency to rate individuals more highly in levels of these social–sexual constructs than do women. This paper reports the results of three meta-analyses that provided estimates of the magnitude of the sex differences in perceptions of flirtatiousness, seductiveness, and promiscuousness and argues that these results are consistent with error management theory. Sex of target and mode of observation interacted to impact observed sex differences. Sex differences were strongest for female targets when research participants were observers of face-to-face interactions (average r=.32), whereas sex differences in evaluations of flirtatiousness, seductiveness, and promiscuousness were strongest for participants who were rating male targets in face-to-face interactions (average r=.36). The implications of these results are discussed.     

运动对我国大学生焦虑情绪影响的meta分析

目的:通过meta分析不同运动方式对我国大学生焦虑情绪影响,寻找降低大学生焦虑的最佳运动方案。方法:制定检索策略、纳入标准和排除标准,通过检索中国知网、万方和维普数据库,检索时间从2011年1月起至2021年3月,按照纳入和排除标准进行文献筛选和数据提取。采用R的"meta"分析软件包进行数据分析。结果:Meta分析结果显示运动干预能显著降低大学生的焦虑自评量表与症状自评量表的焦虑评分SMD=-0.98,95%-CI[-1.25;-0.70],z=-7.01,P <0.01。亚组分析发现,球类运动与有氧运动对焦虑情绪的影响效果明显好于进行运动;每周2次以上运动对焦虑情绪的影响效果好于每周进行2及以下;进行大强度运动对焦虑情绪的影响效果明显好于进行中等强度运动,进行中等强度运动对焦虑情绪的影响效果明显好于进行小强度运动;每次锻炼30-60min与60min以上的锻炼效果不存在显著区别。结论:各种运动均能降低大学生焦虑水平。中大强度球类或有氧运动,每次运动30min以上,每周运动三次及以上对焦虑情绪的影响效果最佳。