Public discourse on HIV and AIDS: an archival analysis of national newspaper reporting in Uganda, 1996–2011

Uganda is recognised as an early success story in the HIV epidemic at least in part due to an open and vigorous national dialogue about HIV prevention. This study examined the national discourse about HIV, AIDS, and young people in New Vision, Uganda's leading national newspaper between 1996 and 2011, building from a previous archival analysis of New Vision reporting by Kirby (1986–1995). We examined the continuing evolution in the public discourse in Uganda, focusing on reporting about young people. An increase in reporting on HIV and AIDS occurred after 2003, as antiretroviral treatment was becoming available. While the emphasis in newspaper reporting about adults and the population at large evolved to reflect the development of new HIV treatment and prevention methods, the majority of the articles focused on young people did not change. Articles about young people continued to emphasise HIV acquisition due to early and premarital sexual activity and the need for social support services for children affected by HIV and AIDS. Articles often did not report on the complex social conditions that shape HIV-related risk among young people, or address young people who are sexually active, married, and/or HIV-infected. With HIV prevalence now increasing among young people and adults in Uganda, greater attention to HIV prevention is needed.     

Oxidative stress in metabolic syndrome

As antioxidants play a protective role in the pathophysiology of diabetes and cardiovascular diseases, understanding the physiological status of antioxidant concentration among people at high risk for developing these conditions, such as Metabolic Syndrome, is of interest. In present study out of 187 first degree non-diabetic relatives and 192 non-diabetic spouses, 33.1% and 19.7% were found to have metabolic syndrome respectively. Subjects with metabolic syndrome (≥3 risk factors) had poor antioxidants status as reflected by significantly low levels of vitamin A, C & E and significantly increased (p<0.01) oxidative stress as compared to those without metabolic syndrome. At the same time serum insulin levels and insulin resistance were found to be significantly high (p<0.001) in metabolic syndrome. A strong positive correlation (r=0.946; p<0.001) between oxidative stress and insulin resistance was observed in metabolic syndrome. Low levels of antioxidants and increased oxidative stress with insulin resistance in metabolic syndrome suggests that besides therapeutic life style changes (TLC) as suggested in ATP III guidelines inclusion of antioxidant vitamins, fruits and vegetable could be beneficial to ward off the consequences of metabolic syndrome.     

Altered Kinetics Properties of Erythrocyte Lactate Dehydrogenase in Type II Diabetic Patients and Its Implications for Lactic Acidosis

Recent studies have been noted that the erythrocytes from Type II diabetic patients show significantly altered structural and functional characteristics along with the changed intracellular concentrations of glycolytic intermediates. More recent studies from our laboratory have shown that the activities of enzymes of glycolytic pathway changed significantly in RBCs from Type II diabetic patients. In particular the levels of lactate dehydrogenase (LDH) increased significantly. Lactic acidosis is an established feature of diabetes and LDH plays a crucial role in conversion of pyruvate to lactate and reportedly, the levels of lactate are significantly high which is consistent with our observation on increased levels of LDH. Owing to this background, we examined the role of erythrocyte LDH in lactic acidosis by studying its kinetics properties in Type II diabetic patients. Km, Vmax and apparent catalytic efficiency were determined using pyruvate and NADH as the substrates. With pyruvate as the substrate the Km values were comparable but Vmax increased significantly in the diabetic group. With NADH as the substrate the enzyme activity of the diabetic group resolved in two components as against a single component in the controls. The Apparent Kcat and Kcat/Km values for pyruvate increased in the diabetic group. The Ki for pyruvate increased by two fold for the enzyme from diabetic group with a marginal decrease in Ki for NADH. The observed changes in catalytic attributes are conducive to enable the enzyme to carry the reaction in forward direction towards conversion of pyruvate to lactate leading to lactic acidosis.     

Effect of oral ingestion of different forms of silver on tissue content of some essential elements in chicks

Silver is ingested in India in the form of varak, Ayurvedic bhasm and water contained in silver utensils, but nobody knows their effects. We have examined the effect of interaction of silver ingested in the form of varak (leaf), bhasm (ash) and water (colloidal solution) on some essential elements (Na, K, Ca, Mg, Cu, Fe and Zn) in blood, liver, spleen and kidneys of chicks. The results showed significant rise of silver in all the tissues and significant fall in copper in the blood. The greatest rise was obtained in blood silver by silver sol while it had the lowest amount of silver. Iron significantly increased in tissues but somewhat decreased in blood. Zinc content increased in all the tissues by leaf and ash but decreased by sol. No consistent pattern was seen in case of other elements.     

ICT and rural societies: Opportunities for growth

The application of ICT solutions for the development of rural India and other developing countries opens up a vast range of possibilities. Giving an opportunity to the vast majority of the population living in rural areas, to cross the digital divide to obtain access to information resources and services provided by ICT is the next revolution waiting to happen. Although this is a development issue, it is just not the government, non-government organizations or the rural masses that have a role to play. Private profit-making institutions can develop solutions to capture the hitherto unrecognized markets, make profits and at the same time aid the rural societies. The new technologies being developed can help surmount barriers present in providing information resources at a low cost and make applications feasible and profitable. This paper presents some cases where ICT has been effectively used for the benefit of the rural societies and analyzes the opportunities that lie in this sphere. The cases range from successful use of ICT in governance, to ICT solutions for improved profits to ICT in microfinance. A case of an initiative by a large mainstream corporation to reach out to the rural sector, help in development and realize profits mutually is also presented. The projects discussed should generate more interest and facilitate private investment in the hitherto virgin territory. A large number of hurdles still remain but creative ideas, breakthrough ICT technologies and committed organizations can usher in the next revolution in the developing world.     

Articulating identities – the role of English language education in Indian universities

ABSTRACT

This paper analyses how community, national and ethnic identities are affirmed, negotiated, marginalized as a part of hegemony-making and resistance in the context of English education in Indian universities. We argue and demonstrate that a complex and ambivalent hegemony that has been operational since the colonial times, continues to shape English education in India. Today, English and English education play a major role in articulating, binding and dividing multiple identities and knowledge systems. In the first part of the paper, we critically review debates and discussions on the significance of English language education in institutes of higher education in India. Specifically, we focus on discourses on the rationale behind continuing and contesting English education. The second part examines how in the postmodern context, English is being taught differently to different groups and highlights how these contexts of teaching have been defining knowledge systems, patterns of dominance and also, articulating resistance.     

Incidence,type and intensity of abuse in street children in India

ObjectiveThe aims of this cross-sectional survey were to examine the prevalence, type and intensity of abuse in street children in Jaipur city, India.MethodBased on purposive random sampling, 200 street children, inclusive of equal number of boys and girls, were selected from the streets of Jaipur city, India, and administered an in-depth interview schedule which included five areas of abuse, namely, “general abuse,” “health abuse,” “verbal abuse,” “physical abuse,” and “psychological abuse.” Data was interpreted using percentages, t-test and correlations.ResultsStreet children reported experiences of abuse in all the five areas under study. Larger numbers of children (61.8%) scored in the “moderate” category of abuse while 36.6% children indicated abuse in “severe” and “very severe” categories on the intensity of abuse. Highest mean scores were obtained on the “verbal” and “psychological” area of abuse. Gender differences were significant in health and overall abuse, indicating boys to be significantly more abused than girls. There were significant positive correlations of abuse with increasing “age” and “income” of street children; and the occurrence of “multi-type” maltreatment and neglect in street children was clearly present.ConclusionDifferent forms of abuse are prevalent in street children in India. This area of study needs attention both by the researchers and the social workers.Practice implicationschildren who are identified in severe and very severe categories of abuse should be worked with in a follow up study with the help of governmental and nongovernmental agencies working in the field for child welfare.     

Discriminative graphical models for faculty homepage discovery

Faculty homepage discovery is an important step toward building an academic portal. Although the general homepage finding tasks have been well studied (e.g., TREC-2001 Web Track), faculty homepage discovery has its own special characteristics and not much focused research has been conducted for this task. In this paper, we view faculty homepage discovery as text categorization problems by utilizing Yahoo BOSS API to generate a small list of high-quality candidate homepages. Because the labels of these pages are not independent, standard text categorization methods such as logistic regression, which classify each page separately, are not well suited for this task. By defining homepage dependence graph, we propose a conditional undirected graphical model to make joint predictions by capturing the dependence of the decisions on all the candidate pages. Three cases of dependencies among faculty candidate homepages are considered for constructing the graphical model. Our model utilizes a discriminative approach so that any informative features can be used conveniently. Learning and inference can be done relatively efficiently for the joint prediction model because the homepage dependence graphs resulting from the three cases of dependencies are not densely connected. An extensive set of experiments have been conducted on two testbeds to show the effectiveness of the proposed discriminative graphical model.     

Altered Erythrocyte Glycolytic Enzyme Activities in Type-II Diabetes

The activity of enzymes of glycolysis has been studied in erythrocytes from type-II diabetic patients in comparison with control. RBC lysate was the source of enzymes. In the diabetics the hexokinase (HK) activity increased 50 % while activities of phosphoglucoisomerase (PGI), phosphofructokinase (PFK) and aldolase (ALD) decreased by 37, 75 and 64 % respectively but were still several folds higher than that of HK. Hence, it is possible that in the diabetic erythrocytes the process of glycolysis could proceed in an unimpaired or in fact may be augmented due to increased levels of G6P. The lactate dehydrogenase (LDH) activity was comparatively high in both the groups; the diabetic group showed 85 % increase. In control group the HK, PFK and ALD activities showed strong positive correlation with blood sugar level while PGI activity did not show any correlation. In the diabetic group only PFK activity showed positive correlation. The LDH activity only in the control group showed positive correlation with marginal increase with increasing concentrations of glucose.