Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

中国北方汉族青年ACE 基因I/ D多态性频率分布特征

通过分析与探讨汉族普通人群ACE基因I／D多态频率分布特征，试图为中国优秀耐力运动员的基因选材研究提供中国人相关人群ACE基因I／D多态频率分布的基础数据。选择18-22岁汉族学生216名作为研究对象，观察其ACE基因I／D多态频率分布。结果显示：北方汉族青年的ACE基因I／D多态频率分布，与国内相关研究结果一致，与欧美人群有非常显著差异。研究认为：从种族单一性、样本数量和年龄段的选择等因素考虑．研究结果不仅可以作为北方汉族青年ACE基因I／D多态频率分布的代表，而且对于杰出耐力的多态性标记研究来讲是理想的对照群体。     

探寻与运动能力有关的基因研究进展

对目前运动能力基因定位研究进展进行了综述.结果发现,与有氧能力有关的基因主要包括ACE、CKMM、ADRA2A及mtDNA的D-loop和MTND5,此外,家系研究提示1p、2p、4q、6p、8q、11p、14q染色体区域可能有与运动能力有关的基因;与肌肉力量有关的基因主要涉及GDF8、 CNTF.但这些基因的作用机制尚不清楚.同时,就今后研究趋势作了展望.     

BLUP法种猪遗传评定在加拿大

饲养在不同猪群的种猪，其生产性能的原始或校正的背膘和年龄数据是遗传和环境的混合，而我们要选择的是遗传部分而不是其所在饲养的环境。估计育种值(EBVs)是种用猪遗传价值的统计估计值，是猪遗传改良方案中的一种新遗传评定系统。它以猪个体性能和其亲属性能为基础，在其选择决策中考虑母猪或公猪家系，考虑性状的遗传力，群内遗传差异以及品种遗传趋势，然后通过最佳线性无偏预测(BLUP)法来计算出EBVs。加拿大全国运用BLUP动物模型对猪生产成绩(100kg时的背膘和日龄)和母猪生产能力(产仔数)进行日常数据计算机处理后得到种猪遗传评定。种猪遗传改进的现行估计是每年背膘和日龄分别下降了0．35毫米和1．5天，这些进展比1985年应用BLUP法前背膘和日龄的下降快50％和200％。目前，对母猪的生产性状，胴体品质的遗传评定工作也已经着手研究。     

ACE基因多态性与有氧耐力运动关系研究

目前普遍认为ACE(血管紧张素转换酶)的水平和心血管的形态、功能密切相关。ACE基因的多态性是人耐力素质优劣的决定性因素之一。为了解运动员血管紧张素转换酶(ACE)基因插入或缺失(I/D）多态性情况，探讨ACE基因多态性与有氧耐力可能的关系，用聚合酶链反应(PCR)技术检测20例运动员和20例健康对照者的ACE基因多态性。结果位于ACE基因16内含子的L／D多态性经PCR扩增后呈三种基因型：纯合子插入型(II）、纯合子缺失型(DD)和杂合子插入或缺失型(ID)。耐力运动员组Ⅱ基因型和Ⅰ等位基因频率显著高于健康对照组。结果表明ACE基因可能在运动员的有氧耐力中起重要作用。     

小生境遗传算法在函数优化中的应用

探讨了基于稳态复制策略的二进制小生境遗传算法,并把其应用于复杂函数优化问题中,通过与基于最优保存策略的基本遗传算法进行比较,说明改进算法可以极大克服遗传算法未成熟收敛问题以及极易陷入局部解问题,提高了算法收敛性能和收敛速度。     

快速、准确的图像阈值分割新方法

图像分割是数字图像处理系统中基本而关键的技术.通过阈值分割是其最简单的技术,它假设目标和背景是可以分离的.详细讨论将自适应遗传算法与OTSU算法相结合应用于最佳阈值的确定中,提出了相应的算法并用于图像分割,由于自适应遗传算法具有全局搜索最优解能力,因此能在很短时间内自动确定阈值.实验仿真结果表明,该方法不仅可以实现准确的图像分割,并且使得分割速度大大提高.     

Improving the learning of Boolean queries by means of a multiobjective IQBE evolutionary algorithm

The Inductive Query By Example (IQBE) paradigm allows a system to automatically derive queries for a specific Information Retrieval System (IRS). Classic IRSs based on this paradigm [Smith, M., & Smith, M. (1997). The use of genetic programming to build Boolean queries for text retrieval through relevance feedback. Journal of Information Science, 23(6), 423–431] generate a single solution (Boolean query) in each run, that with the best fitness value, which is usually based on a weighted combination of the basic performance criteria, precision and recall.     

Genetic analysis for brix weight per stool and its component traits in sugarcane （Saccharum officinarum）

Brix weight per stool (BW) of sugarcane is a complex trait, which is the final product of a combination of many components. Diallel cross experiments were conducted during a period of two years for BW and its five component traits, including stalk diameter (SD), stalk length (SL), stalk number (SN), stalk weight (SW), and brix scale (BS) of sugarcane. Phenotypic data of all the six traits were analyzed by mixed linear model and their phenotype variances were portioned into additive (A),dominance (D), additive×environment interaction (AE) and dominance×environment interaction (DE) effects, and the correlations of A, D, AE and DE effects between BW and its components were estimated. Conditional analysis was employed to investigate the contribution of the components traits to the variances of A, D, AE and DE effects of BW. It was observed that the heritabilities of BW were significantly attributed to A, D and DE by 23.9%, 30.9% and 28.5%, respectively. The variance of A effect for BW was significantly affected by SL, SN and BS by 25.3%, 93.7% and 17.4%, respectively. The variances of D and DE effects for BW were also significantly influenced by all the five components by 5.1%～85.5%. These determinants might be helpful in sugarcane breeding and provide valuable information for multiple-trait improvement of BW.     

Study of Resistin gene expression in peripheral blood mononuclear cell and its gene polymorphism in a small range population

INTRODUCTION Recently discovered as an endocrine organ, adi-pose tissue can secrete many cytokines such as Re-sistin, adiponectin and free fatty acids, and receives much attention in the study of insulin resistance and type 2 diabetes mellitus (T2DM). As a peptide hor-mone secreted by adipocyte, Resistin is considered to be the linkage between obesity and insulin resistance (Steppan et al., 2001). Most studies on Resistin in-vestigate adipose tissue. In this experiment we de-tected t…