| 山莨菪碱对氧自由基诱导羊心肌细胞膜Na~+-K~+-ATP酶活性降低的保护作用 |
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| 引用本文： | 刘磊,张学梅,黄彩云.山莨菪碱对氧自由基诱导羊心肌细胞膜Na~+-K~+-ATP酶活性降低的保护作用[J].大连大学学报,1994(3). |
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| 作者姓名： | 刘磊 张学梅 黄彩云 |
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| 作者单位： | 大连大学医学院药理教研室
(刘磊，张学梅)，大连大学医学院药理教研室(黄彩云) |
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| 摘 要： | 山莨菪碱对正常心肌细胞膜上的Na~+-K~+-ATP醇活性无显著影响,但对氧自由基诱导心肌细胞膜Na~+-K~+-ATP酶活性降低有明显的保护作用,并具有浓度依赖性。当山茛菪碱浓度为2×10~(-4)mol·L~(-1),与对照组相比,酶的活性增高了114.6％,浓度为10~(-3)mol·L~(-1)时,酶的活性增高了164.2％。
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| 关 键 词： | 山莨菪碱 心肌细胞膜 Na~+-K~+-ATP酶 氧自由基 |
Effects of Anisodamine on the Decrease of Na~+-K~+-ATPase Activity Iinduced by Oxygen Free Radicals |
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| Liu Lai.Effects of Anisodamine on the Decrease of Na~+-K~+-ATPase Activity Iinduced by Oxygen Free Radicals[J].Journal of Dalian University,1994(3). |
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| Authors: | Liu Lai |
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| Abstract: | The results showed that Anihad no signitieant effects on Na~+-K~+-ATPase activityin the normal sheep myocardial sarcolemma. But it had a signifficant protective effect on thereduction of Na~+-K~+-ATPase activity induced by oxygen free radicals. The Protectiveeffect was in conceutration-dependent manner. Compard with the control groups, theemzyme activity increased by 114. 6% at 2×10~(-4)mol/L,and 164.2% at 10~(-3)mol/L。 |
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| Keywords: | Anisodamine Na~+-K~+-ATPase Oxyen free radicals |
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