Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects |
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Authors: | Tester F Ashavaid Seema P Todur Kappiareth G Nair |
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Institution: | (1) Research Laboratories, P.D. Hinduja National Hospital & Medical Research Centre, Veer Savarkar Marg, Mahim, 400 016 Mumbai, India |
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Abstract: | Apolipoprotein E genotypes and lipid and lipoprotein levels were determined in hypercholesterolemic and angiographically vertified
CHD subjects and compared against 90 normolipidemic controls. The ε4 allele was significantly prevalent in the hypercholesterolemic
and CHD subjects. Significant increase in total cholesterol levels in apo ε4 containing subjects were observed in the hypercholesterolemic
and CHD group. The study suggests that the ε4 allele by influencing the lipid levels could act as a risk factor for CHD. |
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Keywords: | Apolipoprotein E genotypes alleles |
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