| 间歇运动对自发性高血压大鼠的心功能及心肌IMD受体系统的影响 |
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| 引用本文： | 刘向辉,郝选明.间歇运动对自发性高血压大鼠的心功能及心肌IMD受体系统的影响[J].体育科学,2011,31(2):70-75,89. |
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| 作者姓名： | 刘向辉 郝选明 |
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| 作者单位： | 1. 邵阳学院,体育系,湖南邵阳,422000
2. 华南师范大学体育科学学院,广东广州,510006 |
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| 基金项目： | 湖南省全民健身服务体系建设研究基地资助项目，广东省普通高校人文社会科学研究基地重大项目 |
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| 摘 要： | 目的:探讨间歇运动对自发性高血压大鼠的心功能、心肌组织垂体中叶素(intermedin,IMD)及其受体系统的影响。方法:20只自发性高血压大鼠随机分为运动组和对照组,运动组进行连续10周的间歇运动后,测定大鼠的血压、心功能、心肌组织IMD及其受体系统mRNA水平和蛋白含量、血浆IMD含量。结果:1)运动组SHR的血压、HW/BW、-dp/dt、LVSP、LVDP低于对照组(P<0.05);2)运动组SHR心肌IMD、CRLR、RAMP1-3mRNA水平及蛋白表达水平比对照组显著提高(P<0.05);3)运动组SHR血浆IMD与收缩压、心重/体重及其受体蛋白水平之间呈正相关(P<0.05);而对照组SHR血浆IMD与收缩压呈负相关(P<0.05),与心重/体重及其受体蛋白水平之间呈正相关(P<0.05)。结论:长期的间歇运动诱导了SHR心血管组织IMD及其受体系统的高水平表达,很可能是高血压降血压效应的重要的调控机制之一。
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| 关 键 词： | 高血压 间歇运动 垂体中叶素 降钙素受体样受体 受体活性修饰蛋白 鼠 动物实验 |
Response of Heart Function and Myocardium Intermedin and Its Recipient System of Interval Exercise Training of Spontaneous Hypertensive Rat |
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| LIU Xiang-hui,HAO Xuan-ming.Response of Heart Function and Myocardium Intermedin and Its Recipient System of Interval Exercise Training of Spontaneous Hypertensive Rat[J].China Sport Science,2011,31(2):70-75,89. |
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| Authors: | LIU Xiang-hui HAO Xuan-ming |
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| Institution: | LIU Xiang-hui1,HAO Xuan-ming21.Department of Physical Education of Shaoyang University,Shaoyang 422000,China,2.School of Physical Education,South China Normal University,Guangzhou 510006 |
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| Abstract: | Objective:To investigate the difference of heart function and intermedin(IMD) and its receptor in genetic expression and protein content in myocardium tissue after interval training in SHR.Method:Twenty SHR were randomly divided into two groups,IE group trained in interval training,and CR group was set as control group.The mRNA expression of IMD and its receptor,protein levels of CRLR and RAMPs,the content of IMD in plasma were measured.Result:1) The blood pressure,HW/BW,-dp/dt,LVSP,LVDP of IE group were de... |
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| Keywords: | hypertension interval training intermedin CRLR RAMPs |
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