| 补充扇贝肽对运动大鼠停训后萎缩骨骼肌细胞Caspase-3活性的影响 |
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| 引用本文： | 潘小玲,郭振新,庞阳康.补充扇贝肽对运动大鼠停训后萎缩骨骼肌细胞Caspase-3活性的影响[J].山东体育学院学报,2011,27(7):53-57. |
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| 作者姓名： | 潘小玲 郭振新 庞阳康 |
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| 作者单位： | 1. 广东医学院体育教学部,广东湛江,524023
2. 广东罗定职业技术学院体育系,广东罗定,527200 |
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| 摘 要： | 目的:通过测试萎缩骨骼肌细胞Caspase-3、SOD活性和MDA含量,观察补充扇贝肽对运动大鼠停训导致骨骼肌萎缩后肌细胞Caspase-3活性及其抗氧化能力的影响,研究扇贝肽对停训后骨骼肌萎缩的干预作用。方法:40只SD雄性大鼠以15 m/min的速度,持续性水平跑台训练30 min开始进行递增负荷运动,运动6 d/周,休息1 d/周,速度递增3 m/min/周,时间递增30 min/周,运动3周后即刻处死10只大鼠为基础对照组,其余大鼠随机分组为补充安慰剂阴性对照组、补充牛乳阳性对照组和补充扇贝肽实验组,30只大鼠左侧后肢实施石膏固定模拟停训模型,并进行扇贝肽补充实验。实验组和对照组所有动物每天分别进行灌胃15%扇贝肽饮料2mL、等量的安慰剂和牛乳。结果:发现补充扇贝肽可显著减低停训后萎缩骨骼肌细胞MDA含量增加,增加SOD活性,提高细胞内抗氧化能力,可显著抑制停训后萎缩骨骼肌细胞Caspase-3的活性,从而抑制骨骼肌收缩蛋白和结构蛋白的降解,促进萎缩骨骼肌的恢复。
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| 关 键 词： | 扇贝肽 运动员停训综合症 骨骼肌萎缩 Caspase-3活性 抗氧化能力 大鼠 |
Effects of scallop peptides supplementation on the activity of caspase-3 of atrophic muscle after detraining in rats |
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| PAN Xiao-ling,GUO Zhen-xin,PANG Yang-kang.Effects of scallop peptides supplementation on the activity of caspase-3 of atrophic muscle after detraining in rats[J].Journal of Shandong Physical Education Institute,2011,27(7):53-57. |
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| Authors: | PAN Xiao-ling GUO Zhen-xin PANG Yang-kang |
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| Institution: | PAN Xiao-ling1,GUO Zhen-xin2,PANG Yang-kang1 1.Dept.Physical Education of Guangdong Medical College,Zhanjiang,524023,China,2.Dept.of Physical Education,Luoding Polytechnic College,Luoding 527200,Guangdong |
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| Abstract: | Objective:The effects of scallop peptides supplementation on the activity of caspase-3 and SOD and the content of MDA in skeletal muscle after detraining were investigated.To study the effects of scallop peptides supplementation on muscular atrophy after detraining in rats.Methods:40 male Sprague-Dawley rats ran 30 minutes at speed of 15 m/min,exercise 5 day/week and rest 1 day/week in the first week.In the second week,rats ran 60 minutes at speed of 18 m/min,exercise 5 day/week and rest 1 day/week and ran ... |
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| Keywords: | scallop peptides athletic detraining syndrome muscular atrophy activity of caspase-3 antioxidant capacity rat |
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