12例外阴上皮内瘤变患者的病理及临床分析

为了研究外阴上皮内瘤变患者的诊疗方法和进行疗效分析.总结厂12例VIN患者的临床资料,对其临床表现、HPV感染、病理、治疗方法复发等进行了分析,结果表明:12例VIN患者中,青年组(≤40岁)占41.7%,中老年组(>40岁)占58.3%。HPV感染占41.7%,在青年组和老年组中分别为53.3%、46.7%。12例患者均行手术治疗,局部扩大切除术为25.0%,单纯局部切除术为75.0%.可见,VIN在年轻妇女中的患病有增加趋势,可能与HPV感染有关.治疗宜个体化,手术可采用局部扩大切除或单纯局部切除,同时应强调定期随访.

A Pathological and Clinical Analysis of 12 Cases of VIN

Objective to review the diagnosis methods and treatment modalities of vulvar intraepithelial neoplasia III(VIN III) and to analyse its prognostic factors.The data of 12 patients with VIN III from 1992 to 2002 were respectively reviewed and anaglysed.Results Among these 12 patients,41.7% were aged less than 40 years and 58.3% over 40 years.Human papillomavirus(HPV) infection was found in 53.3% and 46.7% of these two groups.Treatment modality for all patients was surgical excision including extended local excision(25.09/0)and simple vulvectomy(75.0%).Conclusion During recent years,the incidence of VIN has been on the increase in younger woman patients which maybe due to the increase of HPV infection,and the data show that the recurrence rate is correlated with positive margin.Treatment should be individualized and either extended local excision or simple vulvectomy is appropriate.Periodical follow-upshould be done.