CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality |
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Authors: | Hua-feng Wang Yi-zhi Cheng Huan-ping Wang Zhi-mei Chen Ji-yu Lou Jie Jin |
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Institution: | 1. Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China 2. Institute of Hematology, Zhejiang University, Hangzhou, 310003, China 3. Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, 310003, China
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Abstract: | We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the
sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for
cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone
marrow showed 47,XX,+212]/46,XX18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated
in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis
of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond
well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with
trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the
sole acquired karyotypic abnormality was discussed. |
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Keywords: | Trisomy 21 Acute myeloid leukemia Cluster of differentiation 19 (CD19) |
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