| 力竭运动后大鼠外周血mir-24与大脑皮质Bax表达运动性中枢疲劳 |
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| 引用本文： | 黄雅雯.力竭运动后大鼠外周血mir-24与大脑皮质Bax表达运动性中枢疲劳[J].四川体育科学,2012(2):33-35,56. |
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| 作者姓名： | 黄雅雯 |
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| 作者单位： | 私立华联学院,广东广州,510663 |
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| 摘 要： | 目的:探讨一次性力竭游泳运动后大鼠外周血mir-24和大脑皮质bax基因表达变化与运动性中枢疲劳的关系。方法:健康雄性Wista大鼠48只,随机分为对照组(C组)、一次性力竭运动组(E组)。力竭运动后即刻和24h取各组外周血和大脑皮质分别采用real-time PCR和TUNEL法等技术检测各组外周血mir-24和大脑皮质内bax基因表达情况和凋亡情况。结果:1次性力竭运动后即刻,大鼠外周血mir-24和大脑皮质内bax基因的表达均升高(P<0.05),24小时后均基本恢复到安静水平(P>0.05),这与TUNEL检测到凋亡情况一致。结论:凋亡可能是运动性疲劳发生的机制之一,外周血mir-24可能作为运动性疲劳的监测指标。
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| 关 键 词： | 力竭运动 大鼠mir-24 运动性中枢疲劳 |
The Relationships between the Expression of Mir-24 and Bax in Peripheral Blood and Sport Central Neural System Fatigue after Exhaustive Swimming |
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| HUANG Ya-wen.The Relationships between the Expression of Mir-24 and Bax in Peripheral Blood and Sport Central Neural System Fatigue after Exhaustive Swimming[J].Sichuan Sports Science,2012(2):33-35,56. |
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| Authors: | HUANG Ya-wen |
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| Institution: | HUANG Ya-wen Private Hualian College,Guangzhou Guangdong,510663,China. |
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| Abstract: | The purpose of this experiment is to study the relationships between the expression of mir-24 in peripheral blood and bax in cerebral cortex and sport central neural system fatigue after exhaustive swimming.Depending on results of real-time PCR and TUNEL,the present study suggests that the expression of mir-24 in peripheral blood may be a promising marker for sport central neural system fatigue. |
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| Keywords: | Exhaustive swimming Rat mir-24 Sport central neural system fatigue |
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