有氧运动对高脂血症大鼠血清CRP含量的影响

目的:探讨不同时间有氧运动对高脂血症大鼠血清CRP含量的影响。方法:雄性Wistar大鼠40只,随机抽取10只作为正常对照组(NC),其余为高脂血症模型组,高脂血症模型成功后再将高脂组大鼠随机分成高脂血症安静对照组(HC)、高脂血症1小时有氧运动组(HE1)、高脂血症2小时有氧运动组(HE2)。酶免法测定血清CRP。结果:HC组大鼠血清CRP的含量显著高于NC组(P<0.01),HE1组显著低于HC组(P<0.05),但仍明显高于NC组(P<0.05);HE2组与HC组相比虽有下降趋势,但差异无统计学意义,与HE1组相比差异虽无统计学意义,但有上升趋势,仍明显高于NC组(P<0.05)。结论:高脂血症大鼠血清CRP水平有升高现象,提示高脂血症大鼠机体存在一定程度的慢性炎症反应;适量的有氧运动有减轻高脂血症大鼠机体慢性炎症反应的作用;仅就循环CRP水平而言,并非运动时间越长,对高脂血症越有好处。

Effects of Aerobic Exercise on the Content of Serum CRP in the Hyperlipoidemia Rats

Objective ： It investigates the effects of different duration aerobic exercise on the level of serum CRY in hyperlipiodemia rats. Methods ： 40 Wistar male rats arc randomly divided into 4 groups { ten rats each group } ： normal control group （ NC） , and others are hypeilipiodemia groups including quiet control group { HC} , lhour duration aerobic exercise group { HE1 } , and 2 hours duration aerobic exercise group （ HE2 }. The hyperlipemia model was set up by feeding hyperlipiodemia feedstuff. The serum CRP is tested by ELISA. Results： The concentration of serum CRY is higher in HC than NC { p 〈 0. 01 } , lower in HE1 than HC { p 〈 0. 05 } , but significantly higher in HE1 than NC { p 〈 0. 05 }. The concentration of serum CRY in HE2 has a tendency of falling compared with HC, but there is no significant different. However, compared with HE1, there is no signifi3ant different but it is rising. It is still higher in HE2 than NC { p 〈 0. 05 }. Conclusions ： The eoneentration of serum CRP in hyperlipiodemia rats has a tendency of rising. It means that there is a chronic inflammation in hyperlipiodemia rats ＇ body. The concentration of serum CRP is reduced by 1 hour aerobic exercise for 6 weeks. It is not necessarily advantageous of more duration aerobic exercises.