糖的补充对运动性免疫抑制干预作用的研究

为了研究糖的补充对大负荷训练大鼠免疫功能的影响,通过对大鼠进行为期8周、每周6次,每次150min的游泳训练,建立运动性免疫抑制的模型,并补充糖,测定机体淋巴细胞的增殖功能、细胞因子等免疫指标的变化和淋巴细胞凋亡的变化。结果发现:8周的大负荷运动训练后,大鼠外周血液中淋巴细胞转化率、血清IL-2和GM-CSF含量均显著降低,而血清sIL-2R含量和淋巴细胞凋亡率显著增高。从而说明,大负荷的运动训练可能引起外周淋巴细胞凋亡增加,导致机体细胞免疫功能的降低。而在每次训练之前补充糖,可以使训练大鼠外周血液中淋巴细胞转化率、血清IL-2和GM-CSF含量均显著增高,淋巴细胞凋亡率显著降低。从而说明,糖的补充对大负荷训练引起的运动性免疫抑制具有重要的干预作用。

Effects of Carbohydrate Supplement on Exercise-induced Immunosuppression

In order to explore the effects of carbohydrate supplement on immune function after heavy training in rats,Sports immunosuppressive model was established successfully by SD rats were conducted 150 min/day,6days/wk swimming training for 8 weeks in this study.Meanwhile the rats were administrated for carbohydrate.The immunologic indexes including lymphocytic proliferation function,serum cytokine concentration,and apoptosis of lymphocyte in peripheral blood were determined.Results: After heavy training for 8 weeks,the serum IL-2,GM-CSF concentrations and lymphocytic proliferation in peripheral blood decreased significantly,but the serum sIL-2 concentration and rate of lymphocytic apoptosis increased significantly.There were showed that heavy training might decrease immunologic function by increasing rate of lymphocytic apoptosis.Supplement of carbohydrate before per-training might increase the serum IL-2,GM-CSF concentrations and lymphocytic proliferation function,decrease the rate of lymphocytic apoptosis in training rats significantly.There were showed that supplement of carbohydrate had important intervenient effects on exercise-induced immunosuppression.