| 山莨菪碱清除氧自由基和抗脂质过氧化作用 |
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| 引用本文： | 刘磊,张学梅,范劲松.山莨菪碱清除氧自由基和抗脂质过氧化作用[J].大连大学学报,1995(3). |
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| 作者姓名： | 刘磊 张学梅 范劲松 |
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| 作者单位： | 大连大学医学院药理教研室
(刘磊，张学梅)，北京大学生物系生理室(范劲松) |
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| 摘 要： | 山莨菪碱对Fenton反应生成的·OH具育较强的直接清除作用,其IC_(50)为276mg.L~(-1),作用比·OH特异性清除剂甘露醇(IC_(50)为1349mg·L~(-1)强。对黄嘌呤-黄嘌呤氧化酶系统产生的O(?)也有较强的清除作用,其IC_(50)126mg·L~(-1)。山莨菪碱对自由基发生系统(FRGS)诱导离体大鼠心肌匀浆组织产生的脂质过氧化(LPO)作用有明显的抑制效应。对FRGS诱导离体大鼠心肌线粒体膜LPO也有一定的抑制作用。结果提示山莨菪碱的抗脂质过氧化作用与清除氧自由基作用有关。
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| 关 键 词： | 山莨菪碱 甘露醇 羟自由基 超氧阴离子自由基 脂质过氧化 线粒体 大鼠心肌 |
Oxygen free radical scavenging activity and antilipid peroxidation of Anisodamine |
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| Liu tei/Dept.of Phaxmacology,Medical College of Dalian llniversity.Oxygen free radical scavenging activity and antilipid peroxidation of Anisodamine[J].Journal of Dalian University,1995(3). |
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| Authors: | Liu tei/Deptof Phaxmacology Medical College of Dalian llniversity |
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| Abstract: | The oxygen free radical scavenging activity and antilipid peroxidation of Anisodaminewere studied in vitro. Anisodamine possessed significantly scavenging effects on hydroxylradical/ (·OH) produced by Fenton reaction (Fe~(2+)+H_2O_2) and superoxide anion (O(?))produced by xanthine - xanthine oxidase system (the Ic_(50)Were41 · 86mg · L~(-1)and 126mg · L~(-1)espectively) and the scavenging effects of Anisodamine on · oH were significant-ly more potent than that of mannitol, a specific OH scavenger, which was 1349mg · L~(-1).Anisodamine could singificantly inhibit the lipid peroxidation (LPO) of heart homogenateand myocardial mitochondrial membrane induced by free radical generation system(FRGS, Fe~(2+)+ascorbic acid ). The results suggest that the antilipid peroxidation ofAnisodamine may be related to its scavenging effects on oxygen free ralicals. |
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| Keywords: | Anisodamine Mannitol Hydroxyl radical Superoxide anion lipid peroxidation Mitochondria Rat heart |
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