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| H2S对兔离体心脏心率的影响 | |
| 引用本文： | 陈立锋,徐涛,范凌,赵兰平,陈少峰,温晓竞,张晓云,马建伟,尹万斌.H2S对兔离体心脏心率的影响[J].河北北方学院学报(医学版),2009,26(3):18-21. |
| 作者姓名： | 陈立锋 徐涛 范凌 赵兰平 陈少峰 温晓竞 张晓云 马建伟 尹万斌 |
| 作者单位： | 1. 河北北方学院医学院生理教研室,河北,张家口,075000 2. 河北北方学院附属第一医院心血管内科,河北,张家口,075000 3. 河北北方学院附属第一医院血液科,河北,张家口,075000 4. 河北北方学院临床医学本科2006级2班,河北,张家口,075000 |
| 基金项目： | 河北省教育厅基金，河北北方学院基金 |
| 摘 要： | 目的:探讨硫化氢(H2S)对兔离体心脏心率的影响.方法:用标准微电极细胞内记录技术,观测硫化氢对兔右心房心肌细胞动作电位频率的影响.观测指标:自发放电频率(rate of pacemaker firing,RPF).结果:(1) 用200μmol/LNaHS 灌流时,和正常对照组相比,RPF显著减小(P<0.01).(2) 400μmol/L NaHS与对照组比较, RPF显著减小(P<0.01).和200μmol/LNaHS相比,RPF显著减小(P<0.01).(3)以上使RPF减小的效应在NaHS灌流3～5min出现,10min时已经有显著减小(P<0.01),25～30min达到高峰.结论:H2S可浓度依赖性的影响兔离体心脏的心率. |
| 关 键 词： | 心率 电生理 硫化氢 心脏 兔 |
Effects of Hydrogen Sulfide on Heart Rate of Rabbit Hearts in Vitro |
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| CHEN Li-feng,XU Tao,FAN Ling,ZHAO Lan-ping,CHEN Shao-feng,WEN Xiao-jing,ZHANG Xiao-yun,MA Jian-wei,YIN Wan-bin.Effects of Hydrogen Sulfide on Heart Rate of Rabbit Hearts in Vitro[J].Journal of Hebei North University:Medical Edition,2009,26(3):18-21. | |
| Authors: | CHEN Li-feng XU Tao FAN Ling ZHAO Lan-ping CHEN Shao-feng WEN Xiao-jing ZHANG Xiao-yun MA Jian-wei YIN Wan-bin |
| Abstract: | Objective:To explore the effects of hydrogen sulfide (H2S)on the rabbit's heart rate in vitro.Method:By using standard intracellular microelectrode technique to record Ap,hydrogen sulfide was used to investigate the rate of action potential of right atrium myocytes.Electrophysiological porameters examined were:rates of pacemaker firing,RPF.Results:(1)Perfusion with NaHS(H2S donor,200μmol/L) led to a significant decrease in RPF(P<0.01).(2)Application of 400μmol/L NaHS resulted in a significant decrease in RPF(P<0.01).Compared with the result of 200μmol/L NaHS,400μmol/L NaHS showed a significant decrease in RPF(P<0.01).(3) The above mentioned effects occurred after 3～5min of NaHS superfusion,had a significant decrease(P<0.01)after 10 min,and reached the peak within 25～30min.Conclusion:H2S could significantly affect the heart rate of rabbit hearts in vitro in a concentration-depedent manner. |
| Keywords: | Heart Rate Electrophysiology Hydrogen sulfide Heart Rabbit |
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