急性脑损伤脑微循环早期改变的实验研究

目的:研究急性脑损伤早期脑微循环和脑微血管超微结构的改变。方法:采用Feeney's脑落体撞击致伤动物模型,实验动物选用Wistar大鼠,应用内源性过氧化物酶(EPOX)细胞化学示踪微血管。结果:急性脑损伤后2—72小时脑微循环改变的总体特征为“稀”、“细”、“淡”,即伤区及周围血管稀少,管径变细,颜色变淡,提示,脑损伤后早期脑微血管处于高度收缩状态或管腔狭窄、闭塞,血循环减少。结论:脑微循环障碍、脑缺血是继发性脑损害的重要因素,救治重型颅脑损伤要重视防治脑微循环障碍,纠正脑缺血。

THE EARLY CHENGES OF MICROCORCULATION AFTER ACTUE BRAIN INJURY IN RATS

Objictive:This article studied the early chenges of microcirculation and microvascular ultrastructure in rats. Methods:Feeney's technich was employed to establish the contusin and lacration model in Wistar rat. The microvascular was traced by cytochemisty ofEPOX. Results: The general feature of early chenges of microcirculation was "rarefaction","thin"," delicate shade " , it was show that there were few microvascular and the microvascular became slenden and light color in area of brain injury and it's environments. Conclusions:The early disturbaces of cerebral microcirculation are the principle pathological factors of secondry brain insults after acute head injury. So, it is very important for the treatment of head injury toimprove the microcirculation and ischemia of the brain.