Discrete Time Survival Analysis Via Latent Variable Modeling: A Note on Lagged Depression Links to Stroke in Middle and Late Life |
| |
| Authors: | Tenko Raykov Philip B Gorelick Anna Zajacova George A Marcoulides |
| |
| Institution: | 1. Michigan State University;2. Mercy Health Hauenstein Neurosciences at Saint Mary’s, Michigan State University College of Human Medicine, Grand Rapids;3. University of Western Ontario;4. University of California, Santa Barbara |
| |
| Abstract: | This article is concerned with a latent variable modeling approach to discrete time survival analysis that includes both time-invariant and time-varying covariates. The approach is illustrated with data from the Health and Retirement Study, which are utilized to study further the relationship of depression to stroke in middle and late life. Employing lag-1 depression scores as time-varying covariates, in addition to a set of relevant medical and demographic variables as time-invariant covariates collected at baseline, the article addresses a particular aspect of the prominent vascular depression hypothesis representing an important area in aging research, gerontology, geriatrics, and medicine. The results indicate considerable links of immediately prior depression levels to subsequent occurrences of stroke in middle-aged and older adults. The findings complement those reported by Raykov, Gorelick, Zajacova, and Marcoulides (2017), and are consistent with that hypothesis implying depression as a potential warning sign of an impending stroke. |
| |
| Keywords: | depression discrete time survival analysis latent variable modeling time-invariant covariate time-varying covariate vascular depression hypothesis |
|
|
