Correlation study of Carcino Embryonic Antigen &; Cancer Antigen 15.3 in pretreated female breast cancer patients |
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Authors: | K Thriveni Lakshmi Krishnamoorthy Girija Ramaswamy |
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Institution: | (1) Department of Biochemistry, Kidwai Memorial Institute of Oncology, Hosur Road, 560 029 Bangalore, Karnataka |
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Abstract: | Carcino Embryonic Antigen (CEA) and Cancer Antigen 15.3 (CA15.3) are the most common tumor markers in breast cancer patients.
Measurement of circulating tumor markers is a non-invasive quantitative method. Serum levels of CEA and CA 15.3 were studied
in female breast cancer patients prior to treatment. To evaluate the utility of these markers, 207 Breast carcinoma patients
belonging to all the stages were considered. Healthy age matched 75 female individuals formed the control group. The serum
levels of CEA and CA 15.3 were analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Results were taken and compared with
stages, tumor size, node and grade. The serum CA 15.3 levels were significant in all the study parameters whereas serum CEA
levels showed no significant changes with any of the parameters. Measurement of serum CA 15.3 levels showed significant correlation
(24.8%) with advanced stages and larger tumor sizes, whereas serum CEA levels did not show any significant correlation in
breast cancer patients prior to treatment. |
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Keywords: | Breast cancer Tumor markers stage Tumor size Node Grade |
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