| 4-氨基吡啶的绿色合成工艺研究 |
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| 引用本文： | 禹兴海,高艳华,王亚平,陈全德.4-氨基吡啶的绿色合成工艺研究[J].河西学院学报,2014(2):64-66. |
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| 作者姓名： | 禹兴海 高艳华 王亚平 陈全德 |
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| 作者单位： | [1]河西学院化学化工学院 [2]甘肃省高校河西走廊特色资源利用省级重点实验室,甘肃张掖734000 |
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| 摘 要： | 本文报道改进了传统的4-氨基吡啶合成工艺,采用N2O5作为硝化剂,在非酸介质中进行硝化反应,得到N-氧化硝基吡啶,再利用HCOOH/Zn催化转移氢化法,还原得到产品4-氨基吡啶;反应收率较高,是一种清洁高效,相对成本较低的制备4-氨基吡啶的绿色合成方法.
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| 关 键 词： | -氨基吡啶 硝化 催化转移氢化 绿色合成 |
Research into the Green Synthetic Process of 4-aminopyridine |
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| Institution: | Yu Xing-hai, Gao Yan-hua, Wang Ya-ping, Cheng Quan-de ( 1. College of Chemistry and Chemical Engineering; 2. Key laboratory of Hexi Corridor Resources Utilization of Gansu Universities, Zhangye 734000) |
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| Abstract: | In this paper, we improved the traditional synthetic process of 4-aminopyridine which was a crucial intermediate in pharmaceutical industry. The 4-aminopyridine was successfully synthesized via catalytic transfer hydrogenation using formic acid and zinc powder. It was a convenient and low-cost green Synthesis method for the preparation of 4-aminopyridine. |
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| Keywords: | 4-aminopyridine Nitration Transfer hydrogenation catalyst Green synthesis |
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