小鼠肠道菌群失调动物模型的制备

用乳糖酸红霉素（2．94g／kg）、头孢氨苄（6．19g／kg）、盐酸林可霉素（2．02g／kg）、氨苄西林钠（5．5g／kg），3次／天，连续10天灌服小鼠，分别于灌服后第2d、4d、6d、8d、10d、12d、14d、16d对直肠和盲肠粪便中杆菌和球菌的菌落数进行测定。结果表明：灌服抗生素后杆菌菌落数量减少，球菌菌落数量增加，取代杆菌成为直肠和盲肠中的优势菌群；停药后第6d，除盐酸林可霉素组外，其它灌服组杆菌和球菌数量均可逐渐恢复。结论：乳糖酸红霉素、头孢氨苄、盐酸林可霉素及氨苄西林钠均能导致小鼠肠道菌群失调，其中盐酸林可霉素对肠道杆菌的抑制作用较明显，诱导效果较稳定和持久。

Establishment of Experimental Animal Model of Intestinal Microflora Dysbiosis

To establish a mice model of gastrointestinal microflora imbalance,the mice were orally inoculated with Erythromycin Lactobionatefor Injection(2.94g/kg),Cefalexin(6.19g/kg),Lincomycin Hydrochloride Injection(2.02g/kg) and Ampicillin Capsules(5.5g/kg) there times each day for 10 days.The colony of bacillus and coccus in rectum and cecum were detected everyday between 2 and 16 days postinoculation(p.i.).The Results show that during the term of inoculation,the colony of coccus in rectum and cecum gradually inc...