| 腹膜透析对腹腔巨噬细胞产生NO及腹膜形态结构变化的实验研究 |
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| 引用本文： | 杨泽然,李继承,张凯,苏焕兴,宓开鸿,罗依惠,高志刚,郑一波.腹膜透析对腹腔巨噬细胞产生NO及腹膜形态结构变化的实验研究[J].科技通报,1999,15(5):350-353. |
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| 作者姓名： | 杨泽然 李继承 张凯 苏焕兴 宓开鸿 罗依惠 高志刚 郑一波 |
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| 作者单位： | 1. 浙江大学医学院淋巴学研究室,浙江,杭州,310006
2. 杭州红十字会医院肾内科,浙江,杭州,310003 |
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| 基金项目： | 浙江省科委分析测试基金 |
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| 摘 要： | 应用模拟连续不卧床腹膜透析（ＣＡＰＤ）小鼠以研究两种腹膜透析液Ｂｉｅｆｆｅ和Ｂｒａｕｎ对腹腔巨噬细胞（ＭΦ）产生一氧化氮（ＮＯ）的影响及腹膜形态学改变。结果Ｂｉｅｆｆｅ组ＮＯ产量明显高于对照组；Ｂｒａｕｎ组ＮＯ产量在给药１０ｄ至停药１０ｄ也明显高于对照组；两给药组均伴不同程度腹膜间皮细胞脱落、腹膜增厚等改变，表明两种腹膜透析液连续给药可提高腹腔巨噬的ＮＯ产量，这可能与长期ＣＡＰＤ时腹膜间皮细胞的损
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| 关 键 词： | 腹膜透析液 巨噬细胞 一氧化氮 腹膜 |
| 文章编号： | 1001-7119(1999)05-0350-04 |
| 修稿时间： | 1998年8月17日 |
A Dynamical Observation on Nitric Oxide Production of Peritoneal Macrophage and Peritoneal Changes during Peritoneal Dialysis |
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| YANG Ze ran ,LI Ji cheng ,ZHANG Kai.A Dynamical Observation on Nitric Oxide Production of Peritoneal Macrophage and Peritoneal Changes during Peritoneal Dialysis[J].Bulletin of Science and Technology,1999,15(5):350-353. |
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| Authors: | YANG Ze ran LI Ji cheng ZHANG Kai |
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| Institution: | YANG Ze ran 1,LI Ji cheng 1,ZHANG Kai 2 |
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| Abstract: | The effect of PD fluids was made on the NO production by the peritoneal macrophages and the structural changes of the peritoneum. The result showed that the NO concentration in Bieffe group was much higher than that in the control, while in Braun group, the NO concentration was also higher than that in control when examined at the 10th day of PD and 10th day after the PD cessation. The mesothelial damages were observed in both PD groups, which suggested that the constant PD could lead to the higher NO concentration. |
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| Keywords: | PD (peritoneal dialysis) PD fluid peritoneal macrophages NO (nitric oxide) peritoneum |
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