Relationship between hyperuricemia and metabolic syndrome |
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Authors: | Chen Li-ying Zhu Wen-hua Chen Zhou-wen Dai Hong-lei Ren Jing-jing Chen Jian-hua Chen Lei-qian Fang Li-zheng |
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Institution: | (1) Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China |
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Abstract: | Objective To investigate the relationship between metabolic syndrome and hyperuricemia.
Methods A total of 2374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our
study. Hyperuricemia is defined as ≥ 7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI
(American Heart Association/National Heart, Lung, and Blood Institute) criteria.
Results (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%).
(2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood
pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric
acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with
waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased
risk of metabolic syndrome as compared with those without hyperuricemia odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia.
Conclusion Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic
syndrome.
Project supported by the Health Promotion Center in Sir Run Run Shaw Hospital, the Affiliated Hospital of Zhejiang University,
China |
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Keywords: | Hyperuricemia Metabolic syndrome Triglyceride |
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