| 中成药结代停对豚鼠心肌细胞动作电位的影响 |
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| 引用本文： | 许实波,项辉,李锐.中成药结代停对豚鼠心肌细胞动作电位的影响[J].中山大学学报论丛,1994(6). |
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| 作者姓名： | 许实波 项辉 李锐 |
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| 作者单位： | 中山大学生命科学学院药理室
(许实波，项辉)，广州中医学院(李锐) |
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| 摘 要： | 中成药结代停120,60g/L对正常状况下心肌细胞动作电位复极化0％,35％,50％,90％时的动作电位吋程APD_0,APD_(35),APD_(50),APD_(90)均有缩短作用,对动作电位超射值、动作电位幅度及最大去极化速度无显著性影响;可使正常心肌细胞动作电位有效不应期(ERP)延长,使APD_(90)/ERP<1,从而发挥其抗心律作用.
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| 关 键 词： | 结代停 动作电位时程 有效不应期 |
Effect of Chinese Medicine Jedaitin on Action Potential of Isolated Guinea Pig Cardiac Muscle Cell |
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| Xu Shibo Xiang Hui Li Rui Section of Pharmacology,School of Life Sciences,Zhongshan University.Effect of Chinese Medicine Jedaitin on Action Potential of Isolated Guinea Pig Cardiac Muscle Cell[J].Supplement to the Journal of Sun Yatsen University,1994(6). |
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| Authors: | Xu Shibo Xiang Hui Li Rui Section of Pharmacology School of Life Sciences Zhongshan University |
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| Abstract: | Chinese medicine Jedaitin 120g/L, 60g/L shortens action potential durations of guinea pig cardiac muscle cells at repolarization degrees of 35%, 0%, 50%and 90% (APD35, APD0, APD50, APD90) 1 has no effect on transmembrane resting potential (RP) , overshoot (OVS) , action potential amplitude(APA) and maximum depolarization rate; prolongs effective refractory period (ERP) of action potential; and ration of ERP/APD90<1. Jedaitin has an antiarrhythmic action. |
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| Keywords: | Jedaitin action potential durations effective refractory period |
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