| 运动对大鼠心肌GSH、GSSG含量及GSH/GSSG的影响 |
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| 引用本文： | 毛丽娟,李传珠.运动对大鼠心肌GSH、GSSG含量及GSH/GSSG的影响[J].成都体育学院学报,2004,30(1):75-78. |
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| 作者姓名： | 毛丽娟 李传珠 |
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| 作者单位： | 1. 上海交通大学体育科研所,上海,200030
2. 青岛大学师范学院体育系,山东青岛,266071 |
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| 摘 要： | 本实验以游泳训练的大鼠为实验模型,观察雄性SD大鼠心肌GSH、GSSG的含量以及GSH/GSSG的比值.发现经10周递增负荷的游泳训练和长时间力竭运动后,大鼠心肌GSH含量显著下降,GSSG的含量显著升高,心肌的GSH/GSSG的比值降低,P＜0.05,提示长时间力竭运动致活性氧产生增加,GSH/GSSG氧化还原缓冲作用改变的可能性增加,影响了细胞信号传递过程.发现心肌GSH含量有下降趋势.本实验还观察了大鼠心肌中巯基含量,发现巯基与GSH的变化相一致,从侧面反映运动导致机体活性氧产生增加,细胞氧化还原状态发生改变的可能性增加.
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| 关 键 词： | 大鼠游泳训练 氧化还原状态 巯基 |
| 文章编号： | 1001-9154(2004)01-0075-04 |
| 修稿时间： | 2003年9月25日 |
Exercise Effects on the Content of GSH, GSSG, and GSH/GSSG Ratio in Heart |
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| MAO Lijuan,et al.Exercise Effects on the Content of GSH, GSSG, and GSH/GSSG Ratio in Heart[J].Journal of Chengdu Physical Education Institute,2004,30(1):75-78. |
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| Authors: | MAO Lijuan |
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| Institution: | Research Institute of Sports Sciences Shanghai Jiaotong University Shanghai 200030 |
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| Abstract: | The effects of 10 weeks progressive training and exhaustive exercise on GSH, GSSG content and GSH/GSSG ratio were studied in heart of rats. After one time exhausted exercise glutathione in heart was significant decreased, GSSG content increased and GSH/GSSG ration in heart significantly decreased. These results suggest that reactive oxygen species be generated during strenuous exercise as a result of the increased oxygen consumption. Heart GSH content had a tendency of decrease after 10 weeks progressive training. |
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| Keywords: | GSH GSSG |
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