谷氨酰胺对力竭性游泳大鼠心肌组织MDA、GSH含量的影响

目的在于探讨补充外源性谷氨酰胺 (GLN)对力竭性运动大鼠心肌组织中丙二醛 (MDA)和还原型谷胱甘肽(GSH)含量的影响。方法 :采用力竭性游泳运动方式 ,通过补充与不补充GLN对比观察大鼠力竭运动后 18h心肌组织中MDA、GSH含量的变化 ,评价GLN对运动机体心肌组织抗氧能力的影响。结果 :(1)心肌组织MDA含量 ,单纯运动组比安静对照组显著升高 (P <0 .0 1) ,补充GLN运动组心肌MDA含量上升幅度明显低于单纯运动组 ;(2 )心肌组织GSH含量 ,补充GLN安静组高于安静对照组 ,差异显著 (p <0 .0 1) ,补充GLN运动组高于单纯运动组 ,差异显著 (p <0 .0 5 )。结论 :补充外源性GLN有助于提高运动机体心肌组织中的GSH含量 ,增强心肌的抗氧化能力 ,抑制心肌脂质过氧化反应。

GLN's Effect on Concent of MDA. GSH in Myocardium of the Exhausting Swimming Mice

The purpose of this investigation was to establish wether the additional GLN infusion has effiency in the contents of MDA and GSH in rat myocardium. Methods: 18 hours after the sports groups finish the once exhaustive swimming exercise,the contents of MDA and GSH were measured in control group (C)、 control+GLN group (CG)、 sports group (S) and sports+GLN group(SG). Results: (1) the contents of MDA in S is significently higher than C (P<0.01). It is signcificently lower in SG than in S. (2) The contents of GSH is signcificently higher in CG than in C (P<0.01). and is also signcificently higher in SG than in S (P<0.05). Conclusion: the supplement of GLN is beneficical to increase the GSH content in myocardium, improve the anti-oxidizing ability of Myocardium and resist the lipid over-oxdizing reaction of myocardium.