4周有氧运动对肥胖儿童少年动脉粥样硬化致病相关因子的影响

目的:观察4周有氧运动对肥胖儿童少年运动减肥后体脂率、胰岛素、血脂、血管慢性炎症因子等动脉粥样硬化致病相关因子的影响。方法:以参加2011年上海巅峰运动减肥夏令营的30名肥胖儿童少年为研究对象,进行4周中小强度有氧运动为主结合适当饮食控制的减肥运动训练。分别于运动减肥的前一天和最后一天测试受试对象身高、体重、体脂率等身体形态指标及血液指标。结果:运动后肥胖儿童少年体脂率显著下降,空腹血清胰岛素、血脂水平与运动前相比均有明显改善,血清脂蛋白酯酶水平明显升高,脂酰辅酶A胆固醇酰基转移酶-2、肿瘤坏死因子-α、血管内皮细胞生长因子水平显著降低。结论:4周有氧运动可以明显降低肥胖儿童少年的肥胖程度、胰岛素水平,明显改善胰岛素敏感性和血脂代谢,一定程度上抑制血管内皮功能障碍及炎性病变,对预防肥胖青少年成年后发生动脉粥样硬化具有积极的作用。

Effects of 4-Week Aerobic Exercise on Obese Children with Atherosclerosis Related Pathogenic Factors

Objective:To observe the effect of weight reduction on the pathogenic factors of atherosclerosis in obese children through 4-week aerobic exercise.Methods:The subjects were 30 obese children,recruited from weight reduction camps during 2011 in Shanghai and carried out 4-week small and medium intensity aerobic exercise combining with proper diet weight loss and exercise training.The height,weight,body fat Percentage,body shape index and blood index of subjects were measured before and after one day weight loss through exercise.Result:After 4 exercise,these obese children body fat Percentage and serum insulin of reduced significantly(P<0.01).The level of LPL and HDL-C/LDL-C increase while the level of TG,TC,HDL-C,LDL-C,ACAT2,VEGF and TNF-α reduces significantly(P<0.01).Conclusions:4-week weight reduction exercise with proper diet control effectively improves somatometric measurements,lipid metabolism and insulin resistance of obese children and adolescents,to a certain extent,as well as chronic inflammation of vascular,in order to Prevent atherosclerosis and metabolic syndrome after growing up.