| 三碘苯酚乙基纤维素微球的制备 |
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| 引用本文： | 刘瑞丽,姜庆军,刘士远,李文新.三碘苯酚乙基纤维素微球的制备[J].中国科学院研究生院学报,2005,1(5):575-578. |
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| 作者姓名： | 刘瑞丽 姜庆军 刘士远 李文新 |
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| 作者单位： | 1. 中国科学院上海应用物理研究所,上海,201800
2. 第二军医大学,上海,200433 |
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| 摘 要： | 为提高造影剂的颗粒度,减少血池造影剂透过血管壁向组织间质渗出,影响血池造影剂的造影效果,采用液中干燥法( in-liquid drying method)制备了三碘苯酚乙基纤维素微球，研究了三碘苯酚与乙基纤维素的比例对微球成球性，粒径以及载药量的影响，发现两者的比例为1：2时成球性最好，所得微球为规整的球形，微球粒径最小，平均粒径D50为3.68um, 载药量为41.4%。
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| 关 键 词： | 液中干燥法 三碘苯酚 乙基纤维素微球 血池造影剂 |
| 文章编号： | 1002-1175(2005)05-0575-04 |
| 修稿时间： | 2004年7月26日 |
Development of 2,4,6-triiodophenol microspheres with ethylcellulose |
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| LIU Rui-Li,JIANG Qing-Jun,LIU Shi-Yuan,LI Wen-Xin.Development of 2,4,6-triiodophenol microspheres with ethylcellulose[J].Journal of the Graduate School of the Chinese Academy of Sciences,2005,1(5):575-578. |
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| Authors: | LIU Rui-Li JIANG Qing-Jun LIU Shi-Yuan LI Wen-Xin |
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| Institution: | 1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800,
2 The Second Military University, Shanghai 200433 |
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| Abstract: | In this paper, 2,4,6-triiodophenol-ethylcellulose-microsphere was developed by in-liquid drying method, in order to increase the granularity of the X-ray CT contrast agent and to prevent the blood vessel X-ray CT contrast agent from exuding through the vascular wall to the tissue. The influnces of the composition ratio of 2,4,6-triiodophenol: ethylcellulose to the microspheres’ appearance and diameter, and the entrapment of 2,4,6-triiodophenol were studied . It was found that when the composition ratio was 1：2 , the microspheres, appearance was round, the average diameter was only 3.68um, and the entrapment of 2,4,6-triiodophenol was 41.4%. |
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| Keywords: | in-liquid drying method 2 4 6-triiodophenol ethylcellulose microsphere blood vessel X-ray CT contrast agent |
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