| Rotenone induces more serious learning and memory impairment than α-synuclein A30P does in Drosophila |
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| 引用本文： | 俞淑,蒋萌,夏莹,陈秋昱,文铁桥.Rotenone induces more serious learning and memory impairment than α-synuclein A30P does in Drosophila[J].上海大学学报(英文版),2011,15(3):229-234. |
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| 作者姓名： | 俞淑 蒋萌 夏莹 陈秋昱 文铁桥 |
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| 作者单位： | School of Life Sciences;Shanghai University;Institute of Systems Biology; |
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| 基金项目： | supported by the Major State Basic Research and Development Program of China (Grant No.2006CB500702); the National Natural Science Foundation of China (Grant No.31070954); the Innovation Foundation of Shanghai Commission of Education Science and Technology (Grant No.08ZZ41); the Basic Research Foundation of Shanghai Commission of Science and Technology (Grant Nos.03JC14030,09JC1406600) |
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| 摘 要： | Parkinson’s disease (PD) is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra and the accumulation of Lewy bodies. In this study, two Drosophila PD models by exposing Drosophila to rotenone (sporadic PD models) are proposed, and the human α-synuclein A30P protein (family PD models) in Drosophila is expressed respectively. Both models recapitulated the main human PD symptoms including the loss of dopaminergic neurons...
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| 关 键 词： | 记忆障碍 鱼藤酮 果蝇 学习 多巴胺能神经元 运动功能 PD 异质性 |
| 收稿时间： | 15 January 2004 |
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