Abstract:［Purposes］ This study aims to introduce the detailed review methods and initial evaluation form for medical journal editors based on basic principles and methods of clinical research design. ［Methods］ By interpreting the basic principles and methods of clinical research design in medical science, we set up the approach to editor's initial evaluation. The method of keyword retrieval was applied in the evaluation process. By using the important assistant method, we could evaluate the academic quality(including authenticity, innovativeness, and scientificity)of medical papers and design the editor's initial evaluation form. ［Findings］ The process of initial evaluation for medical papers is the process of analyzing the quality and application of basic principles and methods of clinical research design. On this basis, we design the editor's initial evaluation form combining qualitative and quantitative evaluation and illustrate the detailed methods at each evaluation step. ［Conclusions］ The proposed initial examination methods and form are highly practical. It can contribute to improving the evaluation ability of the medical journal editors.