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1.
Pushpa Durgawale Sangita Patil P. S. Shukla Ajit Sontakke Satish Kakade Sunil Yadav 《Indian journal of clinical biochemistry : IJCB》2009,24(1):30-35
Fasting samples of 914 subjects from healthy population were analyzed for total cholesterol, triglyceride and three major
fractions of lipoproteins i.e. high-density lipoprotein cholesterol, low lipoprotein cholesterol and very low-density lipoprotein
cholesterol. The values obtained were (in mg/dl) 165.7±30.2,88.36±31.2, 44.86±10.68, 101.66±29.8 and 18.11±7.35 respectively.
When these subjects were grouped according to the age and sex, no appropriate differences were observed between most of the
groups. Triglycerides were found to be low and HDL cholesterol was high in female when compared with male of similar age.
Beyond age 40 years cholesterol level and low density lipoprotein cholesterol was found to be gradually increased in case
of women. Minor difference was observed with dietary pattern. Present study suggests that clinical evaluation of patient should
be made on the basis of these reference values for Western Maharashtra population. 相似文献
2.
12hrs fasting samples of 1485 apparently healthy, Assamese population in the age group of 20–80 yrs., mostly from the urban
area of Assam were tested for serum lipid profile that includes total cholesterol, triacylglycerol, high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) over
a period of three years. The values (median and range in mg/dl) obtained were 170 (93–263); 110 (40–256); 40 (23–73); 103
(40–173) and 22 (8–51) respectively. After grouping these subjects according to the age and sex no significant difference
were observed between most of the groups. Median and upper range of total cholesterol, HDL-C and LDL-C were found to be higher
in women than in men in all the age groups. But triacylglycerol and VLDL-C concentrations were observed to be higher in the
men than women except in age group of 61–70 yrs. It can be suggested that lipid values obtained in this study can be used
as the reference value, based on which clinical correlation can be made. 相似文献
3.
Zeyu Sun Jiatong Chai Qi Zhou Jiancheng Xu 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(2)
IntroductionReference intervals (RIs) for younger population may not apply to the elderly population. The aim of this study was to establish gender- and age-specific RIs for serum liver function tests among the elderly population and to compare with younger population RIs currently used in China and other countries.Materials and methodsThis was a retrospective study, and subjects (≥ 18 year-old) were recruited from the laboratory information system (LIS) at the First Hospital of Jilin University between April 2020 and April 2021. The following parameters were collected: aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), and direct bilirubin (DBIL). The Tukey method was used to eliminate outliers. Reference intervals were established by the nonparametric method.ResultsA total of 23,597 healthy individuals were enrolled in the study. From all parameters AST, ALT, TP and ALB required no gender partition, while ALT, GGT, TP, ALB and DBIL required different partitions for age. Activities and concentrations of ALT, ALB, and TP showed a downward trend in the elderly aged 60-89. In contrast, DBIL showed a gradual upward trend.ConclusionThe RIs for liver function tests among healthy elderly population were different from those among young population in China. There were apparent gender and age differences in the RIs of liver function for elderly and significant differences compared with national standards and RIs in other countries. Therefore, it is necessary to establish gender- and age-specific RIs for serum liver function tests among the elderly population. 相似文献
4.
The serum PSA is universally accepted as the useful and clinically relevant tumor marker for monitoring therapy and identifying
early recurrence in patients of carcinoma prostate throughout the world. However, application of serum PSA is limited to screening
for early adenocarcinoma prostate among males above fifty years of age.
Serum PSA concentration varies from one population to another in different parts of the world. Many groups of workers have
selected 4 ng/ml of serum PSA as upper limit of normal range without giving due consideration for age specific increase in
serum PSA. There is no single report available on normal decade wise age specific reference intervals for serum PSA in Indian
males.
The present study is undertaken to establish age specific reference intervals in healthy Indian males from 20–89 years belonging
to subpopulation of Andhra Pradesh from South India. Our results revealed lowest concentration of 95 percentile serum PSA
in Indian males compared to other populations globally. Contrary to this, healthy Afro Americans were found to have highest
concentration of serum PSA compared to all other populations. 相似文献
5.
Sangeeta Agnihotri S. B. Pachori D. N. Pandey M. C. Pant 《Indian journal of clinical biochemistry : IJCB》1990,5(2):91-94
The effects of regular feeding ofPyrus malus whole fruit and its juice on total serum cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and phospholipids have been studied in normal albino rabbits. It was observed that the whole fruit as well as juice caused significant and progressive decrease in total serum cholesterol, LDL cholesterol and triglycerides within a period of 30 days. On the other hand, serum phospholipids and HDL cholesterol showed progressive and significant increase. Apparently, whole fruit appeared to bring about more per cent lowering in total cholesterol, LDL cholesterol and more increase in HDL cholesterol as compared to juice. Whole apple fruit also caused increase in body weight of rabbits on 30th day (p<0.05) while oral administration of juice showed insignificant change in body weight even on 30th day (p>0.05). 相似文献
6.
M. M. Goyal A. K. Kalwar R. K. Vyas A. Bhati 《Indian journal of clinical biochemistry : IJCB》2006,21(1):208-210
The association of serum trace elements like selenium, zinc and copper has been found in different types of cancer. This study
was conducted to see the serum level of these three trace elements in cancer esophagus patients. Biopsy confirmed cancer esophagus,
24 patients (12 males, 12 females, mean age 54.5±11.65 year with 23 healthy subjects (16 males, 7 females, mean age 44 ±13.82
years) were included in this study. Both control and study group patients were of same socio-economic status and dietary habits.
Serum zinc and copper level were estimated using standard absorption spectrometer technique and serum selenium by Hydride
generation method.
We observed significant low serum levels of zinc and selenium while high level of serum copper in carcinoma esophagus patients,
as compared with normal healthy controls. This shows an association of serum selenium zinc and copper with cancer esophagus. 相似文献
7.
Haseeb Ahmad Khan Samia Hasan Sobki Abdullah Saleh Alhomida Shaukat Ali Khan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):65-70
This study reports the utilization of serum fructosamine and blood glucose for the screening of gestational diabetes mellitus
(GDM). Blood samples from 165 pregnant women were analyzed for fasting blood glucose (FBG), random blood glucose (RBG) and
serum fructosamine. The actual fructosamine levels were corrected for serum protein (c-Fruct) for more precise presentation.
Two cut-off values of FBG (>5.3 mmol/L and >7.0 mmol/L) and RBG (>7.8 mmol/L and >11.0 mmol/L) were used to classify hyperglycemic
subjects for subsequent evaluation. The average values±standard deviations for FBG, RBG and cFruct were 5.865±1.95, 7.767±3.21
and 2.387±0.47 mmol/L, respectively. FBG levels were significantly correlated with RBG (Pearson correlation=0.597, P<0.001).
Significant correlations were also observed between cFruct and FBG (Pearson correlation=0.673, P<0.001) or RBG (Pearson correlation=0.641,
P<0.001). Out of 165 subjects, 24 (14.5%) cases were classified as hyperglycemic on the basis of FBG>7.0 mmol/L or RBG>11.0
mmol/L; use of lower cut-off values resulted higher frequencies of hyperglycemia. Whereas, a combined criteria of FBG>5.3
mmol/L and cFruct >2.5 mmol/L predicted 35 patients as the most probable hyperglycemic as compared to 32 patients identified
using the criteria of RBG >7.8 mmol/L and cFruct >2.5 mmol/L. These criteria were associated with 4.8% and 3.6% false-positivity
at the expense of 3.6% and 3.0% false-negative outcomes, respectively. The levels of FBG, RBG and cFruct were significantly
higher in hyperglycemic groups (irrespective of grouping criteria) as compared to the respective normal groups. In conclusion,
these findings clearly indicate that the paired values of cFruct with FBG or RBG could help in filtering high-risk individuals
for OGTT and therefore avoiding a unnecessary OGTT. 相似文献
8.
This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines
in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting
blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting
serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P <
0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly
altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated
that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine
concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus
DHA can be a safe and perhaps beneficial supplement to inflammatory diseases. 相似文献
9.
J. V. Gnanou S. Muthayya A. V. Kurpad 《Indian journal of clinical biochemistry : IJCB》2006,21(1):193-195
A sample study of biological variation of plasma ferritin in healthy adult males 19–25 years of age (n=6) in the Indian population
was determined. Venous blood was collected on 3 non-consecutive days during a 3 week period. Plasma ferritin was measured
using enzyme linked immunoassay in an automated immunoassay system. Analytical and Biological variation was calculated. We
found a mean biological variation of 21.64%. Thus, our results indicate that biological variation contributed most to the
intraindividual variation. 相似文献
10.
Ivana Lapi Dunja Rogi Nora Nikolac Gabaj Katarina Kaji Nena Peran Lada Surjan Anamarija uras Valentina Cesar Kocijan Nada Bilopavlovi Fran Smai Mario tefanovi Ivanka Ostroki Leida Tandara Milena Krnjai-Tadijanovi Ivan Gornik Hrvoje Pintari Daniela Marasovi Krstulovi Blaenka Miki Dario Raheli 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(1)
IntroductionBased on the hypothesis that there is a substantial rate of adults with prediabetes and undiagnosed diabetes mellitus (DM), our aim was to perform haemoglobin A1c (HbA1c)-based screening in a cohort of Croatian adults and estimate the prevalence of prediabetes and undiagnosed DM according to American Diabetes Association criteria.Materials and methodsThis multi-center, cross-sectional study performed in six Croatian hospitals included 5527 patients aged 40 to 70 years admitted to the Emergency Department or undergoing a primary care check-up. Haemoglobin A1c was measured from leftover whole blood samples using the enzymatic method on either Alinity c or Architect c-series analyser (Abbott Laboratories, Chicago, USA). Haemoglobin A1c between 39-47 mmol/mol was classified as prediabetes, while ≥ 48 mmol/mol as undiagnosed DM.ResultsAfter exclusion of 435 patients with known DM, the final cohort included 5092 patients (median age 57; 56% males). A total of 882 (17.3%) patients had HbA1c values between 39 and 47 mmol/mol. There were 214 (4.2%) patients with HbA1c ≥ 48 mmol/mol. Prediabetes prevalence ranged from 14.2% to 20.5%, while undiagnosed DM from 3.3% to 7.3%, with statistically significant differences among settings (P < 0.001). Age-stratified analysis showed that prediabetes and undiagnosed DM prevalence increase with age (P < 0.001), being 25.4% and 5.8%, respectively, in patients aged 60 to 70 years.ConclusionUnderlying impairment of glucose metabolism was identified in about one in five adults, with significant number of patients with already overt DM. These results should serve as a starting point for further steps directed towards promotion of preventive measures for DM in Croatia. 相似文献
11.
12.
明确区域人口时空演化特征,有助于推动人口高质量集聚。本文以多源数据为基础,采用人口重心、标准差椭圆、人口分布结构指数、人口-土地一致性系数、空间自相关分析和GIS空间统计分析等方法,从城市群整体、县、乡(镇)和栅格尺度对兰州—西宁城市群人口时空特征进行分析,得出以下结论:①兰西城市群人口呈现规模小、流动性弱、城镇化水平低、人口和城镇化率小幅缓慢增长等基本特点。②人口重心略微西移,人口分布“西北—东南”走向的空间格局基本稳定,呈“核心—外围”式空间结构,兰州、西宁和临夏是3个人口集聚中心,其中兰州市显现出人口集聚的“虹吸效应”。甘青两片人口分布格局存在差异,甘肃片区人口密度中南部高、北部低,青海片区人口以西宁为中心向其他县域“圈层”递减。③海拔是影响兰西城市群人口垂直分布格局的主要地形因素,人口分布的高程梯度效应和河谷盆地集聚指向明显,人口主要集中在海拔低于2400 m的中海拔河谷盆地内。多尺度、多视角的研究结论及相应的对策建议,可为区域人口空间优化布局提供科学依据。 相似文献
13.
【目的】 探究参考文献各指标与论文被引频次之间的关系,为撰写高被引论文、科学评价计量学指标等提供参考。【方法】 以2013年Web of Science中凝聚态物理学科下的12种期刊共计8847篇论文为样本数据,利用负二项回归模型测度了参考文献的4类指标与论文被引频次之间的关系。【结果】 在控制期刊影响因子的前提下,12种期刊的代表时间维度的普赖斯指数都与论文被引频次之间存在显著的正相关关系;在大多数期刊中,参考文献的数量和表征跨学科性的香农指数也对论文的被引频次有显著正影响;而表征论文质量的篇均参考文献被引频次中值与论文被引频次之间的相关关系不明确。【结论】 参考文献的一些指标可能影响论文的被引频次,结合实证结果,对科研工作者合理利用参考文献产出高质量论文提出相应建议。 相似文献
14.
Arvind Kumar Poornima Tewari Sibasis S. Sahoo Arvind Kumar Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(2):10-17
A total of 172 first degree relatives (FDRs) and 178 controls were included in this study. All the cases and controls were
subjected to various anthropometric measurements, fasting and postprandial glucose estimation, fasting insulin measurement
and fasting lipid profile. Results revealed the prevalence of Impaired Fasting Glucose (IFG) (cases 37% Vs controls 11.6%),
Impaired Glucose Tolerance (IGT) (cases 34.3% Vs controls 11.2%) and diabetes (cases 11.05% controls 3.37%) was significantly
higher in first degree relatives. Insulin resistance was measured using various methods, which included fasting plasma insulin
(FPI), Homeostasis Model Assessment for Insulin Resistance (HOMAIR), insulin sensitivity index (ISI) (Mffm/l). Prevalence of insulin resistance (Insulin Resistance) as observed comparing FPI
and HOMAIR in cases and controls was 43.6% and 11.24% (P=0.005) and 37.8% and 12.47% (P=0.000) respectively. Prevalence of IR (Insulin
Resistance) observed in cases having Normal Glucose Tolerance (NGT), Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance
(IGT) and diabetes mellitus measuring FPI Vs HOMAIR was 37.5% vs 30.2%, 45% vs 40%, 38.98% vs 37.28% and 36.84% vs 31.57% as accordingly. However, ISI (Mffm/l) was not found
to be a promising index for IR due to its poor specificity. Though HOMA is taken as gold standard for measurement of IR globally,
our study observed fasting plasma insulin representing high sensitivity (89.7%) and specificity (93.3%) as compared to HOMA.
Thus FPI had emerged in this work as a simple and reliable test for diagnosing insulin resistance across the population susceptible
to develop diabetes including FDRs. 相似文献
15.
X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. Several studies have reported contradictory results for XRCC1 exon 6 C>T (rs1799782) gene polymorphism and cancer risk in Indian population has provided inconsistent results. Therefore, we have performed this meta-analysis to evaluate the relationship between XRCC1 exon 6 C>T gene polymorphism and risk of cancer by published studies. We searched PubMed and Google scholar web databases to cover all studies published on association between XRCC1 exon 6 C>T gene polymorphism and cancer risk. The meta-analysis was carried out and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to appraise the strength of association. In order to derive a more precise estimation of the association, A total of 3197 confirmed cancer cases and 3819 controls were included from eligible seventeen case-controls studies. Results from overall pooled analysis demonstrated suggested that that variant allele (T vs. C: OR 1.301, 95% CI 1.003–1.688, p = 0.047) was associated with the risk of overall cancer. Other genetic models; heterozygous (TC vs. CC: OR 1.108, 95% CI 0.827–1.485, p = 0.491), homozygous (TT vs. CC: OR 1.479, 95% CI 0.877–2.493, p = 0.142), dominant (TT+TC vs. CC: OR 1.228, 95% CI 0.899–1.677, p = 0.196) and recessive (TT vs. TC+CC: OR 1.436, 95% CI 0.970–2.125, p = 0.071) did not reveal statistical association. Publication bias observation was also considered and none was detected during the analysis. The present meta-analysis suggested that the variant allele T of XRCC1 exon 6 gene polymorphism was associated with the risk of cancer. It is therefore pertinent to confirm this finding in a large sample size to divulge the mechanism of this polymorphism and cancer risk in Indian population. 相似文献
16.
M. M. Khanolkar A. V. Sirsat S. S. Walvekar M. S. Bhansali L. J. Desouza 《Indian journal of clinical biochemistry : IJCB》1997,12(1):67-70
Serum beta-glucuronidase activity was estimated by our modified method using two substrates phenolphthalein glucuronide and
p-nitrophenyl glucoronide in 49 healthy subjects and 94 patients with gastrointestinal tract (GIT) carcinoma. The correlation
coefficient using the two substrates was found to be r=0.8383. The method of Gabor Szasz was modified wherein the incubation
time was decreased from 5 hours to 2 hours and the incubation temperature was increased from 25°C to 37°C. The increase in
beta-glucuronidase activity in GIT carcinoma appears to be a good biochemical marker in patients with such type of carcinomas,
a finding not reported in literature to-date.
The modified quantitative method used for estimation of beta-glucuronidase is reliable, accurate, simple and rapid. 相似文献