粘着斑激酶介导的信号传递研究进展

粘着斑激酶(FAK)是一种单亚基、非受体型酪氨酸激酶(NTPTKS)。FAK作为一种信号分子参与了多种途径的信号传递,与细胞的黏附、迁移、侵袭、转移、凋亡等相关。本文从介绍FAK的结构功能入手,着重阐述了近年来FAK所介导的信号传递研究进展。     

布依语中km↑δ^33鹞的虚化

布依语中的km↑δ^33是一个多功能词。在句子中可以作动词、助动词、词头、体标记km↑δ^33后跟一个表动作义动词作谓词中心时。km↑δ^33成为动词词头,意义开始虚化;跟在动词后充结构助词或成为体标记,具有功能词的特征,意义虚化程度更高。     

凉山彝语的表人名词后缀-mo^21和-zw^33

-mo^21和-zw^33是凉山彝语中最常见的表人名词后缀,它们是两个相对的词缀。它们的虚化是一个渐变的过程,是从词根语素到类后缀再到典型后缀的连续统。     

CD生产函数的贝叶斯估计

本文介绍了CD生产函数和贝叶斯估计,用贝叶斯估计方法估计CD生产函数中的参数。     

胃癌患者外周血调节性T细胞CD4+和CD25+的检测及意义

目的:研究胃癌患者外周血中调节性T细胞(T regulatory cells,Tr)的CD4 和CD25 表达与胃癌临床病理的关系,并分析其意义。方法:采用流式细胞术检测44例胃癌患者和10例健康体检者外周血CD4 CD25 Tr水平,并进行分层分析。结果:健康成人对照组外周血Tr表达率为(6.05±1.88)%,胃癌患者外周血CD4 CD25 Tr细胞占总CD4 T细胞的(15.27±4.06)%,与健康对照组比较,外周血CD4 CD25 Tr细胞比率均明显升高,差异有显著统计学意义(P<0.01)。分层分析显示,胃癌外周血Tr表达与淋巴结转移率和TNM分期有着负相关性,淋巴结转移阳性和TNM分期越晚,Tr表达率越高(P<0.05)。结论:胃癌患者外周血CD4 CD25 Tr细胞比率明显升高,并与患者免疫力低下及临床病理存在显著相关性,提示祛除人的CD4 CD25 Tr细胞是一种有效的治疗肿瘤的新方法。     

CD机里不能说的秘密

那时候,我很烦钱小生,他是我认识的最调皮的;男生。有一点高,一点瘦,一张满不在乎的脸,小眼睛,笑起来坏坏的。学习成绩不好,总是在班里号召男生逃课看球赛,     

大肠癌组织中CD105和Ki-67的表达及其临床病理学意义

目的探讨大肠癌组织中CD105和Ki-67的表达及其意义。方法采用免疫组织化学PV-9000法检测50例大肠癌组织和10例正常大肠黏膜组织中CD105和Ki-67的表达,检测肿瘤内微血管密度（MVD）以及计算增殖指数（PI）。结果Ki-67和CD105在大肠癌组织中呈高表达（51．34±24．44,16．44±6．33）,与正常黏膜组织中的表达（21．10±8.66,4．00±1．25）相比较,差异有极显著的统计学意义（P〈0．01）。Ki-67的表达与大肠癌的分化程度、临床分期和淋巴结的转移有关,有显著统计学意义（P〈0．05）。MVD与大肠癌的分化程度、临床分期有关（P〈0．05）,但与淋巴结转移无关（P〉0．05）。Ki-67在大肠癌高微血管密度组的表达（68.28±16．91）明显高于低微血管密度组（30．59±13．90）,差异非常显著（P〈0．01）,Ki钾的表达与MYD呈正相关（r=0．28,P〈0.01））。结论CD105和Ki-67在大肠腺癌的发生发展中起着重要作用,并且同时检测两者的表达对大肠腺癌的抗血管治疗和判断其预后有一定应用价值。     

急性脑梗死患者CD4+、CD8+-T淋巴细胞和肿瘤坏死因子-α变化的研究

目的:探讨脑梗死患者外周血CD4 、CD8 -T淋巴细胞亚群和血清肿瘤坏死因子-α(TNF-α)在脑梗死发病中的作用及两者的相关关系。方法:运用流式细胞仪及酶联免疫检测仪,对45例急性脑梗死患者(观察组)和30名健康体检者(对照组)外周血CD4 、CD8 -T淋巴细胞百分率和血清中TNF-α浓度进行检测,并分析两者的相关性。结果:急性脑梗死患者外周血中CD8 -T淋巴细胞和血清中TNF-α浓度均比对照组显著增加,CD4 -T淋巴细胞及CD4 /CD8 明显减低,且随病情加重而显著改变。结论:急性脑梗死时,患者外周血中CD4 、CD8 -T淋巴细胞和血清中TNF-α浓度异常改变,参与了急性脑梗死的异常病情反应,在脑梗死发病中起重要作用。     

旋转分子马达及其研究进展

旨在介绍分子马达的研究历史及有关旋转分子马达的基本知识,并简述本领域在实验上和理论上的研究进展及所面临的挑战.     

Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients

Objectives: To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of CD97 and its cellular ligand CD55 in gastric carcinomas. Methods: Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PCR for the expression of CD97 and CD55. Results: CD97stalk was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of CD97stalk was frequently observed in tumors of stage Ⅰ and T1 gastric carcinoma patients. The expression of CD97stalk between Stage Ⅰ and Stage Ⅱ, Ⅲ, Ⅳ specimens showed significant difference (P＜0.05), between T1 and T2, T3, T4 specimens also showed significant difference (P＜0.05). Specimens with tumor invasion depth limited in mucosa of T 1 specimens showed higher positive CD55 expression than specimens with the same tumor invasion depth in T2, T3, T4 specimens, the expression of CD55 between T1 and T2, T3, T4 specimens was significantly different (P＜0.05).There was strong correlation between the distribution patterns of CD97stalk and CD55 on tumor tissues (r=0.73, P＜0.05). Signet ring cell carcinomas frequently contained strong CD97stalk and CD55-staining. Conclusions: Our results suggest that CD97stalk is probably involved in the growth, invasion and aggressiveness of gastric carcinomas by binding its cellular ligand CD55. CD97stalk and CD55 could be useful as molecular markers for prognosis and therapy of gastric carcinoma patients.     

Role of CD97stalk and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients

Objectives: To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of CD97 and its cellular ligand CD55 in gastric carcinomas. Methods: Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PCR for the expression of CD97 and CD55. Results: CD97^stalk was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of CD97^stalk was frequently observed in tumors of stage I and T1 gastric carcinoma patients. The expression of CD97^stalk between Stage I and Stage II, III, IV specimens showed significant difference (P<0.05), between T1 and T2, T3, T4 specimens also showed significant difference (P<0.05). Specimens with tumor invasion depth limited in mucosa of T1 specimens showed higher positive CD55 expression than specimens with the same tumor invasion depth in T2, T3, T4 specimens, the expression of CD55 between T1 and T2 T3, T4 specimens was significantly different (P<0.05). There was strong correlation between the distribution patterns of CD97^stalk and CD55 on tumor tissues (r=0.73,P<0.05). Signet ring cell carcinomas frequently contained strong CD97^stalk and CD55-staining. Conclusions: Our results suggest that CD97^stalk is probably involved in the growth, invasion and aggressiveness of gastric carcinomas by binding its cellular ligand CD55. CD97^stalk and CD55 could be useful as molecular markers for prognosis and therapy of gastric carcinoma patients. Project (No. 2004C34010) supported by the Science and Technology Bureau of Zhejiang Province, China     

白细胞介素-33在多发性硬化中的研究进展

白细胞介素33(IL-33)是IL-1家族的最新成员,它与IL-1受体家族成员ST2结合产生生物学效应。IL-33具有双重作用:作为一种细胞内核因子具有调节转录作用,作为一种前炎性细胞因子可引起特异性免疫病理改变;IL-33/ST2传导通路在炎症性和免疫性疾病中发挥重要作用,IL-33在多发性硬化中的作用机制未明,需要对其进行不断的深入研究。     

布依语中k(me)33的虚化

布依语中的k(me)33是一个多功能词.在句子中可以作动词、助动词、词头、体标记k(me)33后跟一个表动作义动词作谓词中心时,k(me)33成为动词词头,意义开始虚化;跟在动词后充结构助词或成为体标记,具有功能词的特征,意义虚化程度更高.     

细胞凋亡的信号传导通路及相关因子研究进展

细胞凋亡是细胞在各种死亡信号刺激后发生的一系列大量激活的主动性细胞死亡过程.细胞凋亡的信号传导主要有两条途径:受体依赖途径(外部途径)和线粒体途径(内部途径),两条途径互相交叉;死亡受体、死亡配体和半胱氨酸蛋白酶等细胞凋亡因子在两条途径中起核心作用.     

浅谈随书光盘的管理与利用

本文阐述了随书光盘的特点,介绍了当前随书光盘典藏管理的几种常用方法,分析了利弊,并结合本馆实际介绍了本馆对随书光盘的管理和利用。     

DAEMON下光盘镜像文件的自动加载

本文介绍了光盘镜像文件和虚拟光驱,并详述了在虚拟光驱DAEMON下光盘镜像文件自动加载的方法。     

CD36与动脉粥样硬化

动脉粥样硬化性心血管疾病是危害人类健康的常见疾病之一.CD36是动脉粥样硬化发生和发展过程中的主要参与者之一,介导巨噬细胞内吞修饰的低密度脂蛋白,形成泡沫细胞,有明显的致动脉粥样硬化作用.本文介绍CD36的生物学特性及其在动脉粥样硬化中的作用.     

浅谈几种常用刻录光盘的制作

本文参考了网上一些有关光盘刻录的文章，讲述了VCD制作、音频光盘制作、安装光盘制作、数据光盘制作、加密光盘制作、ISO镜象文件刻录等常见的光盘的制作方法，以及光盘刻录的一些注意事项。     

谈随书附盘的采编与管理

根据我校图书馆的实际情况，对随书附盘的配套采购、规范著录和科学的收藏管理进行了探讨。