关于EGFR抑制因子的活性化合物研究

表皮生长因子受体（epidermal growth factor receptor,EGFR）自分泌环途径在肿瘤发生发展的一系列过程中起重要作用。大量临床前及早期临床试验结果提示EGHR是肿瘤治疗的靶点。     

极大螺旋藻(Spirulina maxima)藻蓝蛋白基因的克隆及其同源性分析

藻蓝蛋白是红藻和蓝绿藻中一种重要的捕光色素蛋白．克隆了编码极大螺旋藻藻蓝蛋白α和β两个亚基的基因,序列分析表明该基因全长为1119bp．β亚基基因位于α亚基基因上游,两个亚基基因序列长度分别为519bp和489bp,中间被111bp的基因片段间隔．除编码α和β两个亚基的开放阅读密码框外,还存在两个潜在的开放阅读密码框,但这两个密码框的意义还不清楚．比较了该藻蓝蛋白氨基酸序列和来自于其他藻类的藻蓝蛋白氨基酸序列的同源性以及藻蓝蛋白α和β两个亚基之间氨基酸序列的同源性,总的来说其同源性在45．9％．99％之间,α和β两个亚基氨基酸序列同源性为27．1％．藻蓝蛋白包含许多疏水性氨基酸,这些疏水性氨基酸在藻胆蛋白的聚集过程中起着极为重要的作用．分析表明编码藻蓝蛋白α和β两个亚基基因的密码子显示出非对称性．     

Power system disturbance modeling under deregulated environment

The paper proposes a new tool that utilizes windowed-wavelet multi-resolution analysis to model and monitor different disturbances that may take place in a multi-ownership system. PSCAD/EMTDC simulator is used to model part of Al Ain distribution system and the proposed technique is implemented to model different power system disturbances. The local maxima of wavelet expansion coefficients show the ability to model all expected disturbances utilizing a small set of expansion coefficients. Furthermore, the maximum multi-resolution expansion level restricted for each wavelet function can be extended to monitor simultaneously stationary and non-stationary disturbances as well as high and low-frequency components.     

小波变换模极大值点在信号去噪中的应用

如何去除信号中的噪声．得到纯净的信号是信号处理过程中一个热点技术。本研究根据噪声与信号的小波变换模极大值点在多尺度空间上具有不同的特性,对信号进行了噪声消除。试验结果表明,使用傅里叶变换和coif2小波模极大值点法对信号去噪,都能够有效地去除信号中的噪声,且重构后的信号非常逼近原始信号．但coif2小波模极大值点法去噪效果更好。     

基于最小二乘法的行波启动元件新算法

文章提出了利用小波变换进行故障暂态信号奇异性检测的新方法,分析了目前的基于Lipschitz系数的行波启动元件算法,指出其最主要的缺点是只利用相邻尺度的WTMM或WTMS比值来确定Lipschitz系数。而通过拟合各尺度的数据,采用基于最小二乘法的Lipschitz系数进行估算。ATP-EMTP仿真结果表明,改进算法能够更精确的分析故障信号的奇异性。     

极大螺旋藻藻蓝蛋白基因在巴斯德毕赤酵母X-33中表达的研究

通过PCR技术克隆了极大螺旋藻藻蓝蛋白基因，构建了克隆载体和表达载体，并将该基因导入巴斯德毕赤酵母X-33基因组，筛选了能够有效表达藻蓝蛋白基因的毕赤酵母工程菌株PC8，从而为发酵法生产藻蓝蛋白奠定了基础。     

Incidence of microalbuminuria in tobacco chewers

It is well established that smoking increases the risk for cardiovascular disease. From the studies in diabetic subjects it has been shown that smoking induces microalbuminuria and accelerates the progression to end stage renal disease. Little is known whether smoking is also related to microalbuminuria and renal end organ damage in non diabetic subjects. The hypothesis which was put forward that tobacco chewing is related to microalbuminuria and renal functional changes in non diabetic subjects. We therefore performed a population based study in the Anand city of Gujarat in which we studied the relation between tobacco chewing and urinary albumin excretion. Tobacco chewers had a higher urinary albumin excretion (Albumin excretion 373±13.9 mg/day: P<0.01) than those who do not consume tobacco. In conclusion tobacco chewing is associated with albuminuria.     

人工皮二胡与蟒皮二胡声学特性的对比研究

从音乐声学的角度,通过响度、动态范围、谐音时域能量、非谐波成分、频响曲线等方面,对人工皮二胡与蟒皮二胡的音强与音色进行对比研究。     

Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

Infants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P < 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P < 0.001; 95 % CI, 0.88–0.98) in the receiver operating characteristic curve. We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.