共查询到11条相似文献,搜索用时 46 毫秒
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表皮生长因子受体(epidermal growth factor receptor,EGFR)自分泌环途径在肿瘤发生发展的一系列过程中起重要作用。大量临床前及早期临床试验结果提示EGHR是肿瘤治疗的靶点。 相似文献
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藻蓝蛋白是红藻和蓝绿藻中一种重要的捕光色素蛋白.克隆了编码极大螺旋藻藻蓝蛋白α和β两个亚基的基因,序列分析表明该基因全长为1119bp.β亚基基因位于α亚基基因上游,两个亚基基因序列长度分别为519bp和489bp,中间被111bp的基因片段间隔.除编码α和β两个亚基的开放阅读密码框外,还存在两个潜在的开放阅读密码框,但这两个密码框的意义还不清楚.比较了该藻蓝蛋白氨基酸序列和来自于其他藻类的藻蓝蛋白氨基酸序列的同源性以及藻蓝蛋白α和β两个亚基之间氨基酸序列的同源性,总的来说其同源性在45.9%.99%之间,α和β两个亚基氨基酸序列同源性为27.1%.藻蓝蛋白包含许多疏水性氨基酸,这些疏水性氨基酸在藻胆蛋白的聚集过程中起着极为重要的作用.分析表明编码藻蓝蛋白α和β两个亚基基因的密码子显示出非对称性. 相似文献
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The study was conducted on 38 patients admitted into the intensive care unit with a provisional diagnosis of sepsis and 25 apparently healthy volunteers as controls. Serum procalcitonin (PCT) was assayed by an electrochemiluminescence method. Serum ischemia modified albumin (IMA), expressed as absorbance units was assayed by the albumin cobalt binding test. Patients with sepsis had significantly higher IMA levels (1.087 ± 0.786) as compared with those without sepsis (0.085 ± 0.234) with a p value <0.0001. The receiver operator characteristic (ROC) plot showed a sensitivity of 100 % and a specificity of 86.2 %. The area under the curve of the ROC plot was 0.917 with a p value of <0.0001. The higher levels of IMA serve to highlight the occurrence of ischemic damage which could be a prelude to poorer prognosis. The performance characteristics of IMA warrants its inclusion along with PCT as a parameter in the diagnosis of sepsis. 相似文献
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Kritsanee Maneewong Titiporn Mekrungruangwong Saowanee Luangaram Tomon Thongsri Sarawut Kumphune 《Indian journal of clinical biochemistry : IJCB》2011,26(4):389-395
Ischemia modified albumin (IMA) and Protein Carbonyl (PC) have known as proteins that are modified on the similar basis of
oxidative stress induced protein modification and may have diagnostic potential in acute myocardial infarction. This study
aims to evaluate the ability of using IMA and PC content to diagnose Non-ST elevation myocardial infarction (NSTEMI) and efficiency
of combining these two markers. Serum from NSTEMI and healthy control were determined for serum IMA and PC content. The results
showed that both of serum IMA level and PC content in NSTEMI was significantly higher than that of healthy controls. However,
the PC content showed greater diagnostic performance than IMA. Combinatorial determination of serum IMA level with PC content
level was enhanced test efficiency. In conclusion, our finding demonstrated that IMA and PC content can be used as a diagnostic
marker for NSTEMI. 相似文献
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草莓提取物对脂肪酸合酶及脂肪细胞的抑制作用 总被引:1,自引:0,他引:1
脂肪酸合酶(FAS)是治疗肥胖症的潜在靶点.实验测定表明,草莓果肉渣及草莓叶的乙醇提取物再经乙酸乙酯萃取的有效组分对FAS具有强抑制作用,且分别对FAS的底物丙二酸单酰辅酶A、乙酰辅酶A呈非竞争性和竞争性抑制.经HPLC-MS分析,槲皮素和鞣花酸可能是草莓有效组分中起主要作用的物质.草莓叶及果肉渣乙酸乙酯提取组分均可有效抑制3T3-L1前脂肪细胞中脂滴积累,且呈剂量依赖性.实验结果对于研究草莓在防治肥胖症的应用上可能具有重要价值. 相似文献
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目的:探讨使用常用皮肤消毒液(酒精、碘伏、安尔碘)时,蘸有消毒液的无菌棉签在皮肤上的涂擦力度、螺旋消毒方式,以及皮肤消毒面的干燥情况对皮肤消毒效果的影响,及使用常用皮肤消毒液2次涂擦消毒后,消毒处皮肤的干燥时间。方法:随机选取符合纳入标准的80名志愿者,随机分为A、B组各40名,A、B组均接受三种常用皮肤消毒液进行皮肤涂擦消毒,但涂擦力度、螺旋消毒方式、消毒面待干与否均有不同。结果:A、B组志愿者使用不同皮肤消毒液后,手背皮肤菌落数均减少,均可达到皮肤消毒效果标准要求。但只有使用碘伏和安尔碘消毒皮肤时涂擦力度不同,A、B组志愿者手背菌落数差异有统计学意义(P<0.05)。结论:三种皮肤消毒液均可达到良好的消毒效果;涂擦力度的轻重对消毒效果有影响,建议在临床实际中消毒皮肤时使用力度重的消毒手法,而螺旋消毒方式和消毒面待干与否对消毒效果无影响。 相似文献
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Chavan VU Durgawale PP Sayyed AK Sontakke AV Attar NR Patel SB Patil SR Nilakhe SD 《Indian journal of clinical biochemistry : IJCB》2011,26(3):283-289
Twenty-four hour urinary albumin excretion (UAE) is considered as gold standard method for albuminuria measurement, but collection
of 24-h urine is inconvenient. The aim of present study was to evaluate whether albumin: creatinine ratio (ACR) and urinary
albumin concentration (UAC) in different spot urine samples correlate or not with 24-h UAE for screening of microalbuminuria
in type 2 diabetic patients. We collected first morning void (FMV), random urine sample (RUS) and 24-h urine, separately on
consecutive days from 104 type 2 diabetic patients. ACR and UAC in each spot urine sample compared with 24-h UAE with regard
to Pearson correlation coefficient. Pearson’s correlation of albumin: creatinine ratio (ACR) with 24-h UAE was (r = 0.802 and 0.623) in first morning void (FMV) and random urine sample (RUS), respectively. Pearson’s correlation coefficient
of urinary albumin concentration (UAC) compared with 24-h UAE was (r = 0.943 and 0.920), in FMV and RUS, respectively, P < 0.01. Results revealed that values in first morning void (FMV) were better correlated with 24-h urinary albumin excretion
(UAE), than the values in random urine sample (RUS). We conclude that the first morning void (FMV) may be able to replace
24-h urine collection, preferably urinary albumin concentration (UAC) in the initial screening of microalbuminuria in diabetic
patients. 相似文献
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浙江地区中华鳖腐皮病的病原与药敏研究 总被引:3,自引:0,他引:3
中华鳖腐皮病是危害中华鳖最严重的常见病之一,其发病率较高,四季均可流行,给养鳖业生产造成较大经济损失。本研究从浙江地区患病个体的颈部病灶、足部病灶、肝脏及肠壁中共分离到6支菌株。经人工感染毒力测试。鉴定病原为嗜水气单胞菌Aeromonas hydrophila与温和气单胞菌Aeromonas sobria。药敏试验结果表明,这两种致病菌均对新霉素、卡那霉素、氯霉素、氟嗪酸、庆大霉素、红霉素等抗生素高度敏感。而对15种中草药仅高敏于五倍子。 相似文献
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