生物芯片及应用

本概述了生物芯片的发展历史、制作方法及其广阔的应用前景，分析了基因芯片领域的最新成果。生物芯片的发展，必将对人类生活产生深远的影响。因此，生物芯片的研究受到人们的广泛关注。     

生物芯片技术及其应用

本文介绍了生物芯片的概念、主要类型、构建技术和使用方法,阐述了生物芯片在分子生物学、医疗保健、药物研究以及农业等方面的应用及发展前景。     

比指甲盖还小的大医院

1999年1月份,美国人类基因组计划负责人弗朗西斯.柯林斯在<自然遗传学>杂志针对生物芯片的专辑中发表了题为"小芯片大数据"的文章,阐述了利用基因片段预测生物未来的思想.接着在9月份该杂志组织了关于生物芯片的国际大会,就生物芯片的应用前景进行了讨论,与会者一致认为到2000年中期,生物芯片将在产业规模上有一个大的跃迁.     

生物大战

一切都是一只苍蝇引起的。 生物芯片的发展给未来战场的武器制造商们提供了无限宽广的设计思路。人们可以将生物芯片植入任何一种生物的体内,将其改造成生物机器人,承担人类无法完成的任务。微型化、智能化、高效化、专业化的生物芯片不断地被研制出来准备装备军方。     

生物芯片生命从此更加精彩

生物芯片背景资料 生物芯片是国际上九十年代后期发展起来的一项尖端技术.它将多种生物探针高密集地固定在一块小小的玻璃片上,从而达到了一次实验同时检测多种疾病或分析多种生物样本目的. 基因芯片、蛋白芯片等都属于生物芯片的范畴.     

生物芯片技术及其应用

本文介绍了生物芯片的概念、主要类型、构建技术和使用方法，阐述了生物芯片在分子生物学、医疗保健、药物研究以及农业等方面的应用及发展前景。     

生物信息“小精灵”

生物信息“小精灵”是什么呢?我们把生物芯片(Biochips)称为生物信息“小精灵”。那么,生物芯片又是什么?如果把DNA比作记载生命奥秘的密码,那么,生物芯片就是破解这个奥秘的钥匙——密码本。有了它,人类就可以监测人体中基因的微小变化,在病魔发威之前就扼住它的黑手;有了它,人们还可以寻找新的     

生物芯片与生物计算机

3月1日,年仅36岁的清华大学生物芯片中心主任、博士生导师程京教授,来到中南海为朱铸基、李岚清等国务院领导同志及各部部长作了关于生物芯片的科技讲座。生物芯片是能对各种生物分子进行快速特别是并行处理的薄片载体,只有1平方厘米、指甲盖儿大小。它在生命科学、疾病诊治、新药开发、生化武器、司法鉴定、航空航天等领域有广阔的应用前景。世界著名商业杂志《财富》预言：“微处理器使我们的经济发生了根本改变,给人类带来了巨大的财富、改变了我们的生活方式。然而,生物芯片给人类带来的影响可能会更大”。这种生物学和计算机学的…     

改变未来生活的生物芯片

生物芯片是指能对生物分子进行快速并行处理和分析的器件。它们通常是只有指甲盖大小的薄型固体,有多种,包括基因芯片、蛋白质芯片、多糖芯片和神经元芯片等。它们能够从各个层次揭示生命的奥秘,是未来生物芯片实验室系统的组成部分。生物芯片技术起源于20世纪80年代,     

让生物芯片见证中国“加速度”

2009年12月,程京当选中国工程院新院士。 实至名归,从1999年回国至今,10年间,他收获的不仅仅是一系列国内、国际的奖项和荣誉,对他而言,更重要的是能够亲历中国生物芯片的快速发展,并且能带领一支堪称中国生物芯片研发、生产的“国家队”——生物芯片北京国家工程研究中心暨博奥生物有限公司。如今,他们的每一步发展都倍受国内外同行关注。     

道光《城口厅志》的三种印本

《城口厅志》应只有一种版本,即刘绍文主持的道光24年刻本。所见三种印本中,四川本印刷时间更早,书版的毁损程度较轻。城口本、重庆本印刷时间约晚50年,书版的毁损程度较重,但印刷质量较好,内容更完整,并增补有少量光绪年间的材料。城口本中的补正出自近人,讹误较多。     

Influence of family structure and school variables on behavior disorders of children

The purpose of this study was to examine the influence of family structure and school variables on behavior disorders of children. The sample consisted of 1,162 white elementary school children. General information was obtained from school records, and ratings on behavior disorders were obtained from teachers. Data were analyzed using multiple regression analyses of variance. Results indicated that grade in school, sex, social class, ordinal position in the family, and teacher were important variables in the determination of behavior disorders. Whether or not the children were living with both of their natural parents, number of children in the family, if the children were in special education classes, and whether the children were older than usual for their grade in school were less important or were unimportant. The results, especially those that were not expected, were discussed.     

原子吸收法和分光光度法检测废液中铁的比较

分别用火焰原子吸收法和1,10-菲啰啉分光光度法测定铬铁废液中铁的总量.绘制了两种方法的标准曲线,测定了空白值、加标回收率和标准样品.两种方法的空白值都比较稳定,相关性以及斜率等数值都很接近,它们的准确度都比较好,相对标准偏差分别为1.2%和2.6%.两者的平均回收率分别为108%和94%,基本符合实验要求.因此,两种方法的测定结果都在真值允许范围内,它们的标准曲线,精密度和准确性都比较好.两种方法的结果通过t检验,无显著性差异.两者都适用于低浓度的铁溶液,但分光光度法灵敏度稍高.     

切开复位锁定钢板内固定治疗跟骨骨折100例临床观察

目的：探讨切开复位锁定钢板内固定治疗跟骨骨折的临床疗效。方法：分析2008年9月至2011年9月,行切开复位植骨锁定钢板内固定治疗跟骨骨折100例（共103足）。男性76例,女性24例,其中单侧97例,双侧3例。年龄18-64岁,平均（33.19±5.97）岁。按Sanders分型Ⅱ型28例,Ⅲ型62例,IV型10例。均采用跟骨外侧L型切口,切开复位锁定钢板内固定。结果：92例获得随访,随访时间6-30个月,平均18个月。应用Maryland评分系统进行疗效评定。优46例、良40例、中4例（1例双侧跟骨骨折）,优良率93.4%。其中1例出现骨不愈合,再次行距下关节融合术,1例出现皮肤坏死经换药后治愈,1例出现腓肠神经症状。结论：切开复位植骨锁定钢板内固定是治疗跟骨骨折的有效方法。     

几种双希夫碱类热变色物质的合成及其热色性

分别以4种醛和联苯胺为原料,在氮气的保护下,合成了4种双希夫碱类热变色物质,并用红外光谱对其结构进行了表征,用显微熔点仪测定了其熔点、热变色温度．结果表明：合成的化合物结构和目标产物一致,且熔程较短,纯度较高,反应效果理想;该4种希夫碱热变色温度较高,均是性能优良的热变色物质．     

个人消费的极度化膨胀与西罗马帝国的衰亡

罗马帝国时期,君主个人权利凌架于国家之上,无道之君众多,他们不关心国家的隐定与发展,只关心吃喝玩乐。许多公民追随统治者,恣情游乐,成为畸生阶层。由此,导致了社会上以奢侈消费为特征的个人消费极度化膨胀,它的风行使得阶级冲突日益尖锐,政治日益黑暗,道德日见沦丧,从而加速了西罗马帝国的衰亡。     

Effects of psycholinguistic instruction on spelling performance

Two studies were conducted in which phonology‐based instructional strategies designed for improving spelling skills of elementary school children were compared against instruction strategies that relied only on visual exposure of words. The first study involved a total of 93 children. Of these, 46 were instructed by drawing their attention to the psycholinguistic nature of their spelling errors. The remaining 47 children in the comparison group were shown the correct version of all the words. In study II 15 children were placed in a treatment group and were taught phoneme awareness, and 15 children were placed in a comparison group and were exposed to printed words only. In both studies, posttests showed that children taught through psycholinguistic and phoneme awareness methods significantly outperformed the visual training groups. Further, these gains were retained after a period of 2 weeks. © 2001 John Wiley & Sons, Inc.     

Characteristics of a clinical sample of sexually abused children: how boy and girl victims differ

The article describes a clinical sample of 87 boy victims of child sexual abuse and compares them to 226 girl victims. Boys were on average 6.3 years of age at onset of the sexual abuse; girls were 5.5 years. Boys were more likely to be victimized by someone outside the family than girls, but about two-thirds of the boys were abused by someone within the family. Male victims were more often abused by someone who sexually abused other children than were female victims. The majority of perpetrators were men; however girls were more likely than boys to be abused by men, and boys by both men and women. Only a small percentage of the offenders were women acting alone, but boys were more likely to be abused by women than girls. In addition, data on the role relationship between victim and offender and how these relationships differ for boy and girl victims are presented.     

遗传算法

本文介绍遗传算法的相关概念─染色体。适应值函数、复制算子、杂交算子和变异算子,给出算法描述和数值例子;同时给出遗传算法的模式定理和收敛性定理;最后,讨论遗传算法的特点和应用前景．     

Motivational cues as determiners of stimulus control in rats

Four rats were each trained to perform a light-intensity discrimination and a sound-intensity discrimination. For half of the subjects, light training sessions were preceded by food deprivation, and correct choices were reinforced with food. Sound training sessions, on the other hand, were preceded by water deprivation, and correct choices were reinforced with water. For the remaining subjects, light training sessions were associated with water deprivation, whereas sound sessions were associated with food deprivation. When the rats were tested in the presence of compounds of sound and light, choices tended to be controlled by light when testing was preceded by the deprivation condition associated with light discrimination task. Reliably fewer light-consistent choices were made under the other deprivation condition, though some preference for responding on the basis of light remained. Following extended training in the presence of all four combinations of light and sound stimuli, this preference was reduced somewhat. When additional testing sessions were preceded by combined food and water deprivation, the tendency to respond on the basis of either light or sound was shown to be related to both deprivation and reinforcement factors.