中西药治疗类风湿性关节炎概述

类风湿性关节炎(RA)作为一种常见多发病,给病人带来很大的痛苦,但同时此病又迁延难愈,目前对其还没有有效的根治方法。文章就中西药治疗类风湿性关节炎的方法做一概述,为该病的进一步治疗提供参考。     

少数民族医药对类风湿性关节炎的治疗研究进展

文章较系统了介绍和总结近几年我国,壮,苗,藏,蒙,傣,瑶等少数民族医药对于治疗类风湿性关节炎的近几年来的治疗研究进展。     

类风湿性关节炎的研究进展

类风湿性关节炎（Rheumatcid arthritis,RA）是一种以关节滑膜炎为特征的慢性全身性自身免疲性疾病,其具体的病因、发病机制尚未完全清楚,目前也暂无法根治。本文就类风湿性关节炎的致病因素及一般治疗、药物治疗、手术治疗等治疗方法进行综述。     

重组γ干扰素治疗类风湿性关节炎的研究现状

重组γ干扰素能够被人体所耐受,而且有较好的安全性,同时其所产生的副反应较低,如发热等,在临床试验上用于治疗类风湿性关节炎,重组γ干扰素的毒性发生率低于大多数类风湿性关节炎药物,有效率能够达到45-65%。因此,研究人员利用干扰素的单独或联合使用希望能够进一步探索治疗严重类风湿性关节炎的效果。     

关于类风湿性关节炎防治的问答

一、什么是类风湿性关节炎?类风湿性关节炎是侵害关节的疾病。类风湿性关节炎可以导致受侵害关节疼痛、肿胀和僵硬。如果你的一侧膝部或手患有类风湿性关节炎,通常另一侧的膝部和手亦会患有此病。     

中医外治治疗类风湿性关节炎研究进展

类风湿性关节炎(RA)是临床常见疾病之一,由于其病因尚未明确,治疗比较棘手。中医称之为"痹症",中医外治对该病具有副作用小、疗效显著、疗法多样等优势,因而被广泛应用于临床。文章总结分析中医外治治疗RA临床疗效,为RA的临床治疗提供参考。     

民族医药干预类风湿性关节炎动物模型实验的研究进展

民族医药是祖国传统医学的重要组成部分,文章系统介绍和总结了我国壮、藏、蒙等少数民族医药干预类风湿性关节炎动物模型实验研究的进展,并提出未来少数民族医药对于治疗类风湿关节炎的一些展望。     

藏西医结合治疗风湿类风湿性关节炎50例分析报告

现阶段医学界对风湿性关节炎，类风湿性关节炎均无特效药，同时也没确一种理想的治疗方法，该病病期长，治疗显效率低，属于难治性疾病，在临床上以藏药为主，同时适当运用西药对此病进行治疗，取得满意的效果，初步认识到较理想的治疗方法。     

自身免疫性疾病研究的新进展——骨桥蛋白在类风湿性关节炎中的病理机制研究

这项研究对类风湿性关节炎的发病机理和免疫调控做了深入探索,在国际上首次阐明了骨桥蛋白在类风湿性关节炎发病中的作用,发现"骨桥蛋白"是引发类风湿性关节炎的顽凶,为治疗类风湿性关节炎找到了新的临床手段和药物靶点.本文介绍了该项成果的研究背景、意义、主要创新点及方法.     

中医治疗关节炎

《科学生活》苏主任,您好！现如今很多病人来看病时,会问：“医生,我是风湿性关节炎还是类风湿性关节炎？”您可否帮我们读者答疑解惑一下,究竟这“风湿性关节炎”与“类风湿性关节炎”有何不同？     

Lipid peroxidation and antioxidant status in patients with rheumatoid arthritis

The changes in the erythrocyte lipid peroxidation products (MDA), levels of glutathione (GSH), ascorbic acid and plasma vitamin E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GP_X), catalase in erythrocytes and plasma glutathione - S - transferase (GST) activity were estimated in patients with rheumatoid arthritis. This work was undertaken to assess oxidative stress and anti oxidant status in patients with rheumatoid arthritis. It was observed that there was a significant increase in erythrocyte MDA levels, activities of SOD, GP_X, plasma GST and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levels and catalse activity in patients with rheumatoid arthritis when compared to controls. The results of our study suggests higher oxygen free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and Catalase activity, support to the oxidative stress in rheumatoid arthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress.     

Lipid peroxidation and antioxidant status in blood of rheumatoid arthritis patients

The main objective of the study was to assess the oxidative stress in plasma and erythrocytes of rheumatoid arthritis patients by measuring the levels of thiobarbituric acid reactive substances (TBARS), non-enzymatic antioxidants (vitamin E, C and reduced glutathione) and enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx)]. This study has been conducted on twenty-two adult female rheumatoid arthritis patients and an equal number of healthy subjects. Elevated lipid peroxidation and multidirectional changes in the antioxidant defence system were noticed in patients with rheumatoid arthritis. The enhanced lipid peroxidation accompanied by disturbance in antioxidant status indicates that rheumatoid arthritis patients are more prone to free radical mediated oxidative damage.     

独活寄生汤联合来氟米特治疗类风湿关节炎临床研究

目的:对独活寄生汤联合来氟米特片治疗类风湿关节炎的临床疗效进行观察。方法:对独活寄生汤联合来氟米特片治疗类风湿关节炎(肝肾亏虚型)的临床疗效进行回顾性分析;应用随机数字表把纳入的120例患者随机分为治疗组和对照组,两组各60例,对照组给予来氟米特片治疗;治疗组予以独活寄生汤联合来氟米特片治疗,1疗程为6个月,分别于治疗前、治疗1个月、2个月、3个月对患者进行DAS-28评分并采用HAQ健康评估问卷进行生存质量评估。结果:治疗组总有效率、显效率分别为88.33%和80%;对照组总有效率、显效率分别为73.33%和61.61%。总有效率、显效率治疗组均显著优于对照组。两组患者HAQ评分、DAS-28评分在治疗1个月均有所改善,病情得到控制;两组患者HAQ评分、DAS-28评分在2个月后仍继续减少,病情初步缓解,较本组治疗前有显著性差异(P0.05),组间相比仍无显著性差异(P0.05);两组患者在治疗结束时HAQ评分、DAS-28评分明显减少,病情完全控制,较本组治疗前及治疗1个月有显著性差异(P0.05),组间相比均有显著性差异(P0.05)。结论:独活寄生汤联合来氟米特片可有效改善肝肾亏虚型型类风湿关节炎患者的临床症状及实验室指标,且无明显不良反应,提高生存质量,取得了满意效果。     

Comparison of hyaluronic acid in patients with rheumatoid arthritis,systemic sclerosis and systemic lupus erythematosus

IntroductionThe aim of the present study was to determine and compare the concentration of hyaluronic acid (HA) in rheumatoid arthritis (RA), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), and its correlation with parameters of disease activity and duration. The hypothesis was that HA should be increased in rheumatic diseases. We also expected that HA could be a marker of disease activity and inflammation in some of these diseases.Materials and methodsThe study group comprised 149 patients with RA, SSc and SLE hospitalized in the Department of Rheumatology and Internal Diseases, Medical University of Bialystok (Bialystok, Poland) and 30 healthy controls. The concentrations of HA, C-reactive protein (CRP) and rheumatoid factor (RF) were measured using Architect ci8200; haemoglobin, platelets on Sysmex XS-800i; and erythrocyte sedimentation rate (ESR) on Sediplus S 2000 analysers. Statistical analysis was performed using Statistica 13.3 PL.ResultsHyaluronic acid was increased in RA, SLE and SSc when compared to controls (P < 0.001, P = 0.011, and P = 0.015, respectively). There were no differences in HA between rheumatic diseases (P = 0.840). Hyaluronic acid positively correlated with SLE activity (P = 0.025). In RA, HA positively correlated with ESR (P = 0.028) and CRP (P = 0.009). However, HA was not found to correlate with the duration of rheumatic diseases.ConclusionsHyaluronic acid concentration undergoes changes in rheumatic diseases with no difference between RA, SLE and SSc. In RA, HA concentration can be a marker of inflammation, while in SLE patients an indicator of disease activity.     

Altered pattern of lipids in plasma and erythrocyte membranes of rheumatoid arthritis patients

The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism.     

逍遥散治疗气郁质RVVC患者临床对照观察

目的:观察逍遥散治疗气郁质复发性外阴阴道念珠菌病(RVVC)临床疗效差异。方法:通过按照王琦中医体质分类与判定表填写调查问卷表的形式对RVVC患者体质进行分类,对符合气郁质的60例患者随机分为治疗组30例采取逍遥散加硝呋太尔制霉菌素阴道软胶囊治疗,对照组30例单独采用硝呋太尔制霉菌素阴道软胶囊治疗。结果:治疗组对气郁质RVVC患者疗效确切,与对照组疗效对比差异有统计学意义P0.05。结论:辨证论治逍遥散可有效防治气郁质RVVC。     

主动脉夹层31例临床回顾性分析

目的:探讨主动脉夹层患者的临床特点及其与Stanford分型、临床症状的关系,减少误诊率。方法:回顾性分析广西中医药大学附属瑞康医院2005年1月至2015年9月间收治确诊为主动脉夹层的住院治疗患者31例的临床资料、生化指标及转归。按Stanford分型及性别分组,对每组患者进行统计分析。结果:31例患者中男性患者28例,女性3例,既往有高血压病史15例,缺血性心肌病7例,马方综合征1例。5例死亡(2例死于并发症,3例自然破裂),死亡率16.12%。3例行人工血管置换,2例行带膜支架植入成功,男性发病年龄小于女性,二者差异有统计学意义(P=0.043)。女性患病人数明显少于男性。男女组患Stanford A、B型年龄差异无统计学意义;A型住院天数短于B型,但差异无统计学意义(P=0.053);A型转归差于B型;合并高血压患者入院收缩压高于无高血压患者,舒张压二组无差别。结论:在入院治疗患者中,男性患病人数较多。Stanford A型住院天数较短,预后较B型差。     

自血疗法治疗HIV湿疹患者临床观察及对CD4~+T淋巴细胞的影响

目的:观察自血疗法对HIV湿疹患者临床症状体征的影响及CD4~+T淋巴细胞计数的改变。方法:选择HAART治疗1年以上的HIV湿疹患者,随机分入治疗组及对照组。最终完成治疗者30例,其中治疗组15例,对照组15例;治疗组抽取肘部静脉血约4m L注射至单侧曲池穴和足三里穴,每侧穴位约2m L;对照组患者在单侧曲池穴、足三里穴每个穴位注射生理盐水约2m L。所有患者均3天注射1次,两侧穴位交替进行,共治疗90天。两组患者均给予HAART治疗。分别在治疗前后,比较两组患者临床症状、体征积分,CD4~+T淋巴细胞绝对计数和血常规等指标变化。结果:两组患者治疗后,皮损情况较治疗前均有不同程度改善,治疗组总有效率高于对照组,两组总有效率比较没有差异(P0.05)。其中,治疗组脾虚湿阻证和血虚风燥证两种证型皮损改善明显;治疗后,治疗组与治疗前相比,红斑、丘疹、脱屑、苔癣化、瘙痒症状体征改善明显。对照组与治疗前相比,红斑、脱屑、苔癣化、瘙痒等症状体征有改善;治疗后,治疗组与治疗前比较,CD4~+T淋巴细胞绝对计数比较有差异(P0.05),未发现明显不良反应。结论:穴位注射能改善HIV湿疹患者的临床症状和体征。在皮疹改善方面,自血穴位注射在以虚证为主的证型方面较普通穴位注射明显,且自血穴位注射能提高CD4~+T淋巴细胞绝对计数。