Cheat or perish? A theory of scientific customs

Performance incentives have become increasingly important in academia. Evidence suggest that they increase not only researchers’ effort but also their cheating. We develop a principal–agent framework in which a research institution (principal) aims to reward scientific productivity considering the social benefit of research and the remuneration costs. Researchers (agents) take into account what others are doing. As a consequence, the introduction of performance incentives not only leads to fraudulent behavior in the short run, but may also deteriorate the scientific norm in the long run. In the face of these dynamics, the principal pursues two goals: to increase productivity (effort incentive policy) and to deal with fraud (anti-fraud policy). Several factors determine the optimal mix of policies: economic factors (researchers’ cost of providing high or low effort, the societal value of scientific knowledge and the societal costs of scientific misbehavior) and psychological factors (the evolution of norms over time). An important insight of our theory is that when research institutions seek to encourage the production of high quality research, they should also raise the salary for normal research to avoid misconduct.     

Users as innovators? Exploring the limitations of user-driven innovation

Considering users as innovators has gained considerable support over the past 30 years. Eric von Hippel’s work in this area forms a significant part of the theoretical underpinning and evidence behind this concept. Many further studies have been undertaken to support it. It has contributed to our understanding of innovation management in general and new product development in particular. Even so, Lüthje and Herstatt emphasise that empirical findings are scarce and that the most radical innovations of the last 35 years were not developed by users. Thus, in this paper we critically review the lead-user theory and focus on three specific areas of weakness of the lead-user concept (conceptual, methodological, empirical), and argue that improvement in these areas would considerably strengthen its standing. We conclude that although lead users can contribute to the innovation process, this contribution should not be overstated, and that insufficient attention has been paid to the limitations of this theory.     

Fertility or sterility? Darwin,Naudin and the problem of experimental hybridity

Darwin came to realize that he could never devise an experiment that would demonstrate the development of new species by crossing hybrids. Instead, he turned to the problem of sterility within a species. The difference between Darwin's experimental and theoretical approach and that of French scientists working in the Muséum d'Histoire Naturelle in Paris can be shown most vividly by tracking Darwin's experiments in botany and his interest in those of Charles Naudin on hybrid plants. In his discussion of Mendel, Robert Olby has provided an interesting analysis of Naudin's hereditary concepts. I have approached some of the same work here with an emphasis on the question of sterility raised by Darwin, not simply between hybrids but within members of the same species and the light that he thought this could throw on both heredity and the origin of species.     

Defining laboratory medicine,or squaring the circle?

In the August 2020 issue of Clinical Chemistry and Laboratory Medicine, Giuseppe Lippi and Mario Plebani proposed a definition of laboratory medicine, which ends with this sentence: “The results of these measurements are translated into actionable information for improving the care and/or maintaining the wellness of both a single individual and an entire population”. Nevertheless, the selfishness of individuals may, sometimes, jeopardize the interest of whole populations. The virtue of justice being within the reach of the entire human community more than of single individuals, the final sentence in the definition proposed by Giuseppe Lippi and Mario Plebani, should therefore, in our view, be rewritten, less selfishly, for example like this: “For a given investment, these measurements are preferably made when they bring as much beneficence, and non-maleficence, as possible to the whole population”.     

Zero,single, or multi? Genre of web pages through the users’ perspective

The goal of the study presented in this article is to investigate to what extent the classification of a web page by a single genre matches the users’ perspective. The extent of agreement on a single genre label for a web page can help understand whether there is a need for a different classification scheme that overrides the single-genre labelling. My hypothesis is that a single genre label does not account for the users’ perspective. In order to test this hypothesis, I submitted a restricted number of web pages (25 web pages) to a large number of web users (135 subjects) asking them to assign only a single genre label to each of the web pages. Users could choose from a list of 21 genre labels, or select one of the two ‘escape’ options, i.e. ‘Add a label’ and ‘I don’t know’. The rationale was to observe the level of agreement on a single genre label per web page, and draw some conclusions about the appropriateness of limiting the assignment to only a single label when doing genre classification of web pages. Results show that users largely disagree on the label to be assigned to a web page.     

Review Article��Dielectrophoresis: Status of the theory, technology, and applications

A review is presented of the present status of the theory, the developed technology and the current applications of dielectrophoresis (DEP). Over the past 10 years around 2000 publications have addressed these three aspects, and current trends suggest that the theory and technology have matured sufficiently for most effort to now be directed towards applying DEP to unmet needs in such areas as biosensors, cell therapeutics, drug discovery, medical diagnostics, microfluidics, nanoassembly, and particle filtration. The dipole approximation to describe the DEP force acting on a particle subjected to a nonuniform electric field has evolved to include multipole contributions, the perturbing effects arising from interactions with other cells and boundary surfaces, and the influence of electrical double-layer polarizations that must be considered for nanoparticles. Theoretical modelling of the electric field gradients generated by different electrode designs has also reached an advanced state. Advances in the technology include the development of sophisticated electrode designs, along with the introduction of new materials (e.g., silicone polymers, dry film resist) and methods for fabricating the electrodes and microfluidics of DEP devices (photo and electron beam lithography, laser ablation, thin film techniques, CMOS technology). Around three-quarters of the 300 or so scientific publications now being published each year on DEP are directed towards practical applications, and this is matched with an increasing number of patent applications. A summary of the US patents granted since January 2005 is given, along with an outline of the small number of perceived industrial applications (e.g., mineral separation, micropolishing, manipulation and dispensing of fluid droplets, manipulation and assembly of micro components). The technology has also advanced sufficiently for DEP to be used as a tool to manipulate nanoparticles (e.g., carbon nanotubes, nano wires, gold and metal oxide nanoparticles) for the fabrication of devices and sensors. Most efforts are now being directed towards biomedical applications, such as the spatial manipulation and selective separation∕enrichment of target cells or bacteria, high-throughput molecular screening, biosensors, immunoassays, and the artificial engineering of three-dimensional cell constructs. DEP is able to manipulate and sort cells without the need for biochemical labels or other bioengineered tags, and without contact to any surfaces. This opens up potentially important applications of DEP as a tool to address an unmet need in stem cell research and therapy.     

Sicily or the Sea of Tranquility? Mapping and naming the moon

In their race to provide the ultimate guide to the moon, two 17th-century astronomers proposed lunar maps and nomenclatures that they hoped would gain international currency. But the names we use today were those proposed by the Jesuit, a friend of Galileo's persecutors, in a book whose purpose was to refute the Copernican system once and for all. We now believe that Riccioli was wrong about the universe, but why do we still use his nomenclature? The keys to this foundational visual debate in astronomical image-making are the moon maps themselves.     

James Hutton and his theory of the Earth, 1787–1987

James Hutton's theory of the decay and renewal of continents and of the infinite time required for a cycle to be completed, met with a mixed reception two centuries ago. He was obliged to collect further evidence from rock outcrops and was able to demonstrate conclusively that the Earth is a machine fired by heat and that the cycle of decay and renewal is repeated.     

Entrepreneurs, Jacks of all trades or Hobos?

Lazear (2005) suggests that entrepreneurs should be generalists, while those who work for others should be specialists. Many prospective entrepreneurs will develop varied skills by engaging in a variety of employment activities prior to becoming an entrepreneur, and incomes are higher for those that do so. An alternative view predicts that those with greater taste for variety are more likely to become entrepreneurs. Varied employment prior to becoming an entrepreneur is simply an expression of this taste, and is associated with lower earnings. Data from a survey of 830 independent inventors and 300 individuals from the general population are used to discriminate between these two theories. The results show that inventor-entrepreneurs typically have a more varied labor market experience, and that varied work experience is associated with lower household income.     

A theory of the internal ballistics of the “hoch-und-niederdruck kanone”

During the war the Germans developed guns with a constriction between chamber and bore, so that the pressure in the chamber was substantially higher than that in the bore. It is shown that a simple theory of such guns can be devised, which is adequate for analysis of firing trials and for testing the claims advanced for this idea. The claim of a high piezometric efficiency is not supported by this theoretical analysis.     

Bridges or isolates? Investigating the social networks of academic inventors

We analyze the acquaintances of a sample of academic inventors and their paired controls to investigate the contribution of social networks to the generation of inventive ideas in academe. Prior to patenting, inventors work in networks of similar dimension and structure as those of their colleagues who do not invent. The ego-networks of the inventors are however more cohesive (denser), a circumstance that is often seen as associated to the exchange of more fine-grained information and to a greater climate of trust which facilitates long-term relationships and learning. Over time, both inventors and non-inventors extend their networks and become more central. In general, we found no evidence that after patenting inventors isolate or close their networks.     

Wearable energy systems:what are the limits and limitations?

<正>The recent decade marks a sharp rise in wearable electronics with a market size approaching 100 billion USD.Along-side this boom in consumer wearable electronics,researchers have pursued,during the past 15 years,next-generation wearable electronics featuring thin,soft,conformal,flexible and stretchable form factors for application in advanced human-machine interaction and comprehensive sensing.     

Joseph Fourier,the ‘greenhouse effect’, and the quest for a universal theory of terrestrial temperatures

The central role that the theory of terrestrial temperatures played in Fourier's mathematical physics has not received the attention it deserves from historians, although his cryptic allusions to the heating of a greenhouse, taken out of context, have been widely cited by subsequent authors.