共查询到19条相似文献,搜索用时 823 毫秒
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基于Innography平台的青蒿素类药物专利情报分析 总被引:4,自引:0,他引:4
青蒿素类药物对全球防治疟疾等传染性疾病,保护世界人民的生命健康安全具有重要作用。基于Innography专利分析平台,从专利申请、专利布局、专利技术来源、竞争态势、IPC技术类别等角度对全球和中国青蒿素类药物研发的发展态势进行探讨,并在挖掘该领域核心专利的基础上,进一步分析核心专利的来源国家、专利权人及技术主题状况。研究表明,全球青蒿素类药物研发正处于快速发展时期,中国拥有该领域大量专利,但绝大多数核心专利均掌握在美国等西方国家手中。研究可为全面了解青蒿素类药物研发的发展状况,制定科学的产业发展政策提供重要参考。 相似文献
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通过查阅文献资料、实地访谈,对广东青蒿科技团队在后青蒿素时代开展青蒿素药物国际产业化研发实践的案例研究,探讨我国具有知识产权的青蒿药物企业开拓国际抗疟药市场的成功经验:由政府、企业资源集成的国外抗疟基地和大学科技园平台,增强了团队产业化研发创新能力;以产、学、研集成的青蒿药物全价值链,优化了团队产业化研发创新结构;靠国内外相关政策、法律信息的集成运用,提升了团队产业化研发创新决策效率;把团队文化价值目标作为文化集成指南,激发了团队产业化研发创新活力。其中,产学研自主创新联盟是青蒿药物国际产业化研发创新主体;在兼顾自主知识产权基础上通过国外抗疟基地实现国际抗疟药市场突破是一有效策略;遵守世界卫生组织规则、关注国内外医药卫生政策法规信息变化是青蒿药物国际产业化研发基础;"根除地球疟疾,造福人类"的抗疟文化价值目标是青蒿药物国际产业化研发动力。 相似文献
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早在公元4世纪,中医就主张用青蒿“治疟”。1972年,中国科学家从青蒿中成功开发出具有极强抗疟疾的药物。但一直没人能解释青蒿素的抗疟原理。最近,英国圣乔治医院医学院科学家宣布,他们破解了这一中草药的抗疟奥秘。 相似文献
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Neda Dadgar Seyed Ebrahim Alavi Maedeh Koohi Moftakhari Esfahani Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2013,28(4):410-412
Nano carriers have greatly revolutionized the treatment of most diseases recently. One of these nano carriers, liposomes, has got particular significance. On the other hand, Artemisinin which is used as an effective anticancer drug has some side effects. To reduce such side effects, liposomes can be employed. In order to prepare pegylated nanoliposomal artemisinin, particular proportions of phosphatidylcholine, polyethylene glycol 2000 and artemisinin were combined. As a result, the mean diameter of nano liposomes is 455 nm. Besides, the encapsulation efficiency and the drug release from pegylated nanoliposomes for pegylated nanoliposomal artemisinin are respectively 91.62 ± 3.5 and 5.17 %. The results also show that IC50 of the produced formulation is less than that of the standard drug. This study reveals that the amount of artemisinin cytotoxicity compared to standard drug is increased by pegylated nanoliposomal formulation. 相似文献
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张正国 《科学.经济.社会》2008,26(1):22-26
建设高水平大学已成为我国高等教育的战略重点和战略任务.本文认为建设高水平学首先要重视战略管理,走向科学发展,具体包括战略定位、战略规划和战略实施.其次要明确发展路经,走向深度变革.大学深度变革要树立和坚持以人为本的发展理念,具体来讲一要推进人才培养模式的变革,构建创新型人才培养体系;二要坚持人才强校战略,构建人才队伍引进、培养、支助和科学评价体系;三要将研究与创新结合起来,构建国家目标和自由探索相结合,强化基础研究和知识创新、促进应用开发和技术创新、繁荣哲学社会科学和理论创新的创新体系.最后,高水平大学必须引领文化发展,走向文化自觉. 相似文献
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科研不端行为的纠偏模式初探 总被引:1,自引:1,他引:0
科研不端行为在国内外皆存在。产生科研不端行为的原因在于科学认知过程的复杂性及社会、文化环境的影响。对科研不端行为的纠偏应采取认知控制、社会控制及文化控制等方式。 相似文献
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Neda Dadgar Maedeh Koohi Moftakhari Esfahani Sepideh Torabi Seyed Ebrahim Alavi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2014,29(4):501-504
This study is aimed to investigate the nanoliposomal artemisinin preparation, and its implementation on breast cancer cells. Side effects have been one of the common challenges of drug usage, as well as cancer treatment. In order to reduce such effects, nanotechnology has been a great help. Nanoliposomes are provided through reverse phase evaporation. In this method, certain proportions of phosphatidylcholine, cholesterol and artemisinin were mixed together. Besides, the obtained formulation was pegylated by using polyethylene glycol 2000 in order to increase its stability and solubility. The mean diameter of non-pegylated and pegylated liposomal artemisinin was determined by Zeta sizer system. The percent of drug released from liposome was performed by dialysis. The encapsulation efficiency of both formulations was estimated by spectrophotometry method. As a result, encapsulation and drug release of nanoliposomal formulation were more than the pegylation of the same formulation. In addition, this study indicated that cytotoxicity effect of pegylated nanoliposomal artemisinin was more, in comparison with nanoliposomal artemisinin. 相似文献
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采用文献研究法,首先分析了文化与价值的意义、科学研究的文化价值意义,即人类的存在与一定社会的文化及价值意识形态联系在一起,科学研究是一种文化现象并在价值观念等层次上深刻影响着文化,进而推导出高校科协的文化价值意义:高校科协是科技工作者的群众组织,是推动科学文化传播和先进文化建设的主要阵地;内部群体文化与同类价值意识对科技工作者个体文化人格的形成发挥价值导向功能;在学术文化交流过程中通过批判、继承和创造进行文化融合;在传播、普及科学知识过程中以自身的观念、意识、行为去影响公众。高校科协应构建具有感召力、影响力和凝聚力的文化价值体系,引领科技工作者开展科学研究,促进社会文化不断向前发展。 相似文献
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王彦雨 《科学技术与辩证法》2014,(5):107-112
“介入策略”的形成与发展是STS研究纲领逐渐成熟的重要标志,它赋予STS研究者进入科学世界现实之轨的能力。随着STS的规范转向,STS逐步由“科学场介入”(简称“介入I”)转变为“社会场介入”(简称“介入Ⅱ”),介入策略通过与规范转向结盟使STS进入广泛的社会空间之中,“社会行动力”成为当代STS介入策略的新内涵。“介入Ⅱ”策略虽然为STS获得很多声誉,但也面对诸如“社会认同不足”等难题,文章提出了STS介入策略的未来发展路径——“自觉式介入”之路,包括“认识论自觉”、“方法论自觉”、“发展路径自觉”及“理论创新自觉”。 相似文献
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以新疆伊犁马文化科学实践转向为案例,以科学、真理与民主理论体系为指导,以农牧民的民生改善为价值取向,探索以伊犁马改良为动因的马业和以民生改善为目标的马文化发展的科学实践哲学两个方面。以科学实践哲学理论指导新疆马文化产业从传统转向现代并取得创新成果,以期对中国西部马产业和马文化产业产生一般规律性的、科学实践哲学的指导作用。 相似文献
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Christine Hine 《The Information Society》2005,21(4):239-248
Perspectives from the sociology of scientific knowledge are deployed to explore the birth of Internet research, focusing in particular on the development of methodological approaches. For a researcher based in the sociology of scientific knowledge, being an Internet researcher has been a vivid opportunity to experience at firsthand a phenomenon usually studied from the outside. The article begins by assessing some models of the process of scientific change. Characterizing Internet research as new has been a potent resource for enrolling researchers into the field and positioning research responses. The development of virtual methods for doing social research illustrates the process of methodological innovation in social science and the negotiation of methodological adequacy. Methodological discussions have been enlivened by the advent of the Internet as an object of study. Internet research has arguably been a valuable reflexive opportunity for the traditional disciplines that have fed its development. 相似文献