罗格列酮改善链脲霉素诱导的糖尿病小鼠认知障碍及机制研究

目的:研究罗格列酮(rosiglitazone)对链脲霉素诱导的1 型糖尿病小鼠认知功能的影响及其作用机制.方法:单剂量尾静脉注射(iv)链脲霉素(150 mg·kg-1)诱导小鼠1 型糖尿病模型,将造模成功(空腹血糖>11.1 mmol·L-1)的小鼠随机分为3 组:模型组,罗格列酮3.2,1.6 mg·kg-1·d-1 剂量组;另设正常对照组,每组10～12只,连续灌胃(ig)给药6 周.第6 周采用Morris 水迷宫和Y 迷宫实验评价认知功能,并检测空腹血糖、血清胰岛素、海马和皮层区Aβ40,Aβ42,糖尿病动物脑内β分泌酶(β-site amyloid precursor protein cleaving enzyme,BACE1)含量.结果:与模型组相比,罗格列酮3.2 mg·kg-1 剂量组能显著缩短糖尿病小鼠定位航行试验的潜伏期(P<0.05),增加空间探索实验中平台所在象限的停留时间百分率(P<0.05),并增加糖尿病小鼠在Y 迷宫测试中的正确反应次数(P<0.05);罗格列酮对1 型糖尿病小鼠空腹血糖和胰岛素水平无显著影响;罗格列酮3.2 mg·kg-1 剂量显著降低糖尿病小鼠脑内海马和皮层区Aβ40(P<0.05,P<0.05)和Aβ42(P<0.05,P<0.05)的水平而对海马和皮层区BACE1 水平无显著影响.结论:罗格列酮3.2 mg·kg-1 剂量可通过降低脑内Aβ水平而改善1 型糖尿病小鼠认知障碍.     

双孢蘑菇提取液对小鼠胃排空的影响

采用改良酚红(PSP)含量测定法,分别以正常、新斯的明负荷、肾上腺素负荷小鼠为实验研究模型,探索双孢蘑菇对小鼠胃排空的影响.结果表明:双孢蘑菇提取液(4.00 g.kg-1)1次性ig给药可显著抑制正常小鼠的胃排空(P<0.01);对肾上腺素负荷小鼠引起的胃排空抑制没有明显的促进作用(P>0.05);对新斯的明负荷小鼠引起的胃排空亢进有显著的拮抗作用(P<0.01).     

护理干预对妇科腹腔镜手术患者的影响

目的 分析影响妇科腹腔镜手术患者康复的因素.方法 58例用腹腔镜进行妇科手术的患者,随机分成干预组(32例),对照组(26例).两组患者的性别、年龄、文化程度、差异无统计学意义(P>0.05).对照组采用常规护理,干预组加以心理、行为干预.均于入院后进行心理学调查和测量血压、心率.结果 两组患者入院后血压、心率差异均无统计学意义(P>0.05);而手术前日干预组血压、心率明显减慢.而对照组血压、心率明显增快,与对照组比较存在明显差异(P<0.05).结论 手术患者术前进行心理护理干预有助消除焦虑和抑郁的心理,维持血压、心率的稳定.     

柴胡疏肝散醇提物对抑郁模型小鼠的抗抑郁作用

目的：研究柴胡疏肝散（chaihu shugan powder,CSGS）乙醇提取物对抑郁模型小鼠行为学的影响。方法：采用慢性不可预见温和应激法（chronic unpredictable mild stress,CUMS）与慢性束缚应激法（chronic restraint stress,CRS）相结合复制小鼠抑郁模型,以柴胡疏肝散水体物为阳性对照,采用体质量增长趋势、蔗糖饮水实验、敞箱实验、情绪性行为评分、悬尾实验、强迫游泳实验来评价柴胡疏肝散醇提物抗抑郁作用。结果：CUMS与CRS相结合可以导致小鼠抑郁：与正常组相比,模型组小鼠体质量增长趋势明显减慢（P〈0.01）;在蔗糖饮水实验中,模型组小鼠的蔗糖水偏嗜度下降;在敞箱实验中,模型组小鼠水平运动次数和垂直运动次数均显著性下降（P〈0.01,P〈0.05）;在情绪性行为评分实验中,模型组小鼠情绪评分显著性降低（P〈0.05）;在悬尾实验中,模型组小鼠的悬尾不动时间显著性升高（P〈0.01）;在强迫游泳实验中,模型组小鼠的游泳不动时间显著性升高（P〈0.01）。与模型组相比,柴胡疏肝散水提组和醇提物16.4、8.2、4.1 g·kg-1剂量组均可改善小鼠的抑郁症状（P〈0.05,P〈0.01）且具有剂量相关性。同是8.2 g·kg-1的生药量,与水提物组比较,醇提物组小鼠实验d 28体质量明显高于水提物组（P〈0.05）,敞箱实验中水平运动次数明显高于水提物组（P〈0.05）,强迫游泳实验中游泳不动时间明显低于水提物组（P〈0.05）。结论：本实验通过CUMS与CRS相结合方法成功复制了小鼠抑郁模型。柴胡疏肝散醇提物对此抑郁模型小鼠具有明显的抗抑郁作用。     

复方中药对荷EAC鼠淋巴细胞功能的作用

[目的]探讨复方中药(FFZY)对EAC荷瘤小鼠的抑瘤效果及脾淋巴细胞转化率的影响。[方法]将60只雄性昆明种小鼠随机分成6组,除空白对照外,其余各组小鼠于右腋窝皮下接种瘤细胞0.2ml/只。种瘤后第一天分别用高、中和低浓度的复方中药溶液灌胃,每次0.02ml/g体重,1次/d,阳性对照组用香菇多糖溶液灌胃,4.255ug/g体重,1次/d,空白组和阴性对照组用生理盐水代替,0.02ml/g体质量,1次/d,连续10d。取脾脏标本,测其脾系数;用MTT法测定脾淋巴细胞增殖率。[结果](1)荷瘤小鼠脾系数均高于空白对照组(P<0.05);高、中和低浓度组均高于阴性对照组(P<0.05),其中以高、中浓度为明显。(2)与空白对照组相比,高、中和低浓度组能明显提高小鼠脾淋巴细胞转化增殖(P<0.01),阴性对照组小鼠脾淋巴细胞转化率较空白组低(P<0.05)。[结论]复方中药能提高EAC荷瘤小鼠的脾系数以及脾淋巴细胞转化率;3种不同浓度FFZY用药后均可使肿瘤生长减慢,提示复方中药可能通过提高EAC荷瘤小鼠脾淋巴细胞的转化率而达到抗肿瘤作用。     

杏鲍菇提取液对小鼠小肠推进功能的影响

摘要:观察食用菌——杏鲍菇(Pleurotus eryngii DC.ex Fr.)对小鼠小肠功能的影响.以正常、新斯的明负荷、肾上腺素负荷为研究模型,采用炭末小肠推进试验法.杏鲍菇提取液1次性ig给药12 g.kg-1可显著促进正常小鼠的小肠运动(P<0.05);杏鲍菇提取液对肾上腺素负荷引起小鼠小肠推进抑制有极显著的促进作用(P<0.01);对新斯的明负荷小鼠引起的小肠推进亢进没有明显拮抗作用(P>0.05).杏鲍菇提取液有加强小鼠小肠运动功能的功效.     

牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响

目的:探讨牛磺酸锌(TZC)拮抗汞对神经系统的损害作用.方法:选用健康Wistar大鼠64只,昆明种小鼠60只分别随机分组,对照组、染汞组、汞+TZC组,大鼠采用Y迷宫,小鼠采用穿梭实验,观察染汞组和不同浓度TZC组的鼠学习记忆能力的变化.结果:汞可导致大鼠学习记忆能力下降(P<0.05),不同浓度的TZC均可缓解汞致大鼠学习记忆能力下降(P<0.05).结论:TZC在一定程度上能拮抗汞对神经系统毒性作用.     

迎春花水提物对小白鼠免疫功能的影响

观察迎春花水提物对小白鼠免疫功能的影响,将小鼠分为低、中、高剂量组迎春花水提物5 g.kg-1、10 g.kg-1和15 g.kg-1,通过测定小鼠免疫器官指数、巨噬细胞吞噬指数和E-玫瑰花环形成率来评价迎春花水提物对小鼠免疫功能的影响.结果显示迎春花水提物能显著增强小鼠胸腺指数和脾指数,提高腹腔巨噬细胞的吞噬功能及E-玫瑰花环形成率(P<0.05).研究结果表明,迎春花水提物能显著增强小白鼠免疫功能.     

白术醇提取物对老年小鼠记忆障碍的改善作用

探讨白术醇提取物(AME)对老年小鼠记忆障碍的改善及海马乙酰胆碱酯酶(AChE)活力的影响。实验动物分为5组:对照组选用4月龄昆明种小鼠(12只),老年组与AME组选用18月龄昆明种小鼠(48只)。采用避暗实验检测小鼠的记忆能力,生化测定小鼠海马AChE活力的变化。结果显示:(1)避暗实验中,与对照组比,老年组小鼠的步入潜伏期明显缩短(P<0.05),错误次数明显增多(P<0.01);与老年组比,中、高剂量AME组小鼠的步入潜伏期明显延长(P<0.05,P<0.01),错误次数明显减少(P<0.05)。(2)生化测定表明,与对照组比,老年组小鼠海马AChE活力显著增加(P<0.01);与老年组比,中、高剂量AME组小鼠的ACh E活力显著降低(P<0.01)。结果提示AME对老年记忆障碍有一定的改善作用,机制可能与其降低海马AChE活力有关。     

肌胺肽苷注射液联合心理干预对伴焦虑抑郁障碍冠心病介入治疗患者的疗效观察

目的:探讨伴焦虑抑郁障碍冠心病患者接受介入治疗前后情况以及肌胺肽苷注射液联合心理干预的效果.方法:采用Zung抑郁自评量表(SDS)、焦虑自评量表(SAS)对201例拟接受冠脉介入治疗的冠心病患者进行焦虑抑郁障碍调查评分.将201例患者随机分为联合干预组和对照组,干预组在手术前1～2d和手术后7～10d静点肌胺肽苷注射液,同时于上述时段以及术后3月、6月、12月、24月给予心理干预,对照组常规治疗并于同样时间进行焦虑抑郁评定和心理干预.结果: 术前两组患者抑郁发生率、SDS评分无显著差异.术后干预组的抑郁障碍较对照组有明显改善(SDS评分分别为36.54±4.25和46.17±6.42, P<0.01),手术前后干预组抑郁发生率无明显差异,而对照组术后抑郁发生率明显高于手术前(SDS评分分别为46.54±6.25和73.46±6.73, P<0.01),干预组出院后24个月内再住院、心血管事件发生率明显低于对照组,生活质量提高明显高于对照组.多因素分析显示:教育水平低下、近期负性生活事件、社会经济地位、病程绵长、导管介入治疗后遗症与冠心病抑郁之间存在明显相关(P<0.01);且抑郁程度与患者出院后恢复、恶性心血管事件发生之间存在明显相关(P<0.01).结论:肌胺肽苷注射液联合心理干预可以有效减轻抑郁焦虑障碍和降低心血管事件的发生,提高患者的生活质量.     

卡思卡特城堡

It is worthy of noting that, whilst Crookston Castle witnessed the earlier and happier portion of Mary's variegated life,     

只要努力,不要后悔

There are numbers of crossroads on our long and unpredictable life journey where we totally have no idea about which direction to choose. No matter what our decision is, we should not turn back, but face the music and go ahead instead. I am this kind of girl who always does try without regretting, one example is how I dealt with my love.     

浅谈移民问题

Migration occurs behind a variety of reasons and has a great effect on the whole world. People may migrate in order to improve their economic situation, or in order to escape civil strife, persecution, and environmental disasters. The impact of migration is complex, bringing both benefits anddisadvantages. This paper briefly talks about the causes of migration, the allocation of benefits, and the ways in which individual countries and the international community deal with this important subject.     

Sister Carrie, an Adherent of Desires

Sister Carrie is one of the most controversial characters in American literature.Thought as a "fallen woman" firstly,she was defined as a "new woman" by some critics later. However, by digging into the motivaton behind the whole process of Carrie's "success", the relationship between Carrie and her creator (the author), the social conditions of then American, it can be found that Carrie has never been free-standing on her thought and she has never found her real-sdf even after becoming a famous actress. In a society dominated by mass consumerism Carrie is only an adherent of her own desires. She also is a representative of all those country girls flooded into cities, a symbol and a sacrifice of the urbanization of America in a time countryside was overcome by cities.     

Improvement of one-cycle controller by use of proportional integral differential controller

1.IntroductionOne-cyclecontrolmethod,whichwasproposedaboutonedecadeago[1],hasbecomeanattractivemethodinspecialfieldssuchaspowerfactorcorrection[2-6],switchingamplifiers[7,8],etc.Themainideaofthiscontrollerisbasedonintegrationofdiodevoltageinone-cycleandforcesittobeexactlyequaltothereferencevalue.Themainadvantageofthiscontrollerisitsrealtimeabilitytorejectthevariationofinputvoltage[1].Despitethisgreatability,ithasnogoodperformancesinrejectingofloaddisturbanceandfollowingreferencecommands.Espec…     

胡主席在印度,我却在中国

Today, Sunday morning, I sit thinking and typing at my computer. My thoughts are in my homeland, India and my body is in China. The body is here and mind there for a good reason. Mr. Hu is president and I am resident and both are in each other's countries (what a difference the absence of one small letter makes!). Mr. Hu will return in a few days and I will stay on longer.     

STORIES

正A One day a pig went to the stable(马棚)to see his good friend,an oldhorse,and was going to stay there forthenight.Night came and it was time forsleep.The pig went into the straw heap(稻草堆)and lay comfortably.A longtime passed,but the horse was stillstanding there and did not move.Thepig asked the horse why he did not go tosleep."Standing like this is the begin-ning ofsleeping,"answered the horse.     

巧妙引语(英文)

正1.Any fool can count the seeds in an apple.Only God can count all the apples in one seed.2.Happy families are all alike;every unhappy family is unhappy in its own way.3.Memories are the key not to the past,but to the future.4.Sometimes in the dark you see what you want to see.5.There is a great difference between     

Information for Authors

正Scope and Policy The Journal of Chongqing University-English Edition(JCQU-E)is a peerreviewed journal publishing research articles in multiple disciplines of science and technology,covering civil and environmental engineering,chemical engineering,biotechnology,mechanical and electrical engineering,computer and data processing,mining,metallurgy,materials science,and interdisciplines thereof.