非酒精性脂肪性肝病与胃肠功能紊乱关系的研究进展

非酒精性脂肪性肝病(Non-alcoholic fatty liver disease,NAFLD)是指除外酒精和其他明确的肝损害因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征.根据流行病学调查,NAFLD已成为危害人类健康的重要肝病之一,越来越多的研究显示,NAFLD与胃肠功能紊乱(Function...     

非酒精性脂肪性肝病对肾功能指标影响的研究进展

酒精性脂肪性肝病是目前世界上常见的肝病之一,其发病率正不断升高.迄今为止,已有许多研究均指出非酒精性脂肪性肝病与慢性肾脏病显著相关.文章通过介绍目前为止两者的流行病学概述,以及归纳非酒精性脂肪性肝病与肾功能指标的诸多相关研究,简单总结了非酒精性脂肪性肝病可能引起慢性肾脏病的可能的机制.     

祛湿活血方治疗非酒精性脂肪性肝病的研究近况

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是除外酒精和其他明确的损肝因素所致的,以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征。据调查研究,NAFLD是我国最常见的慢性肝病之一,其患病率不断上升,越来越多研究显示,NAFLD的演变发展潜在较多的危害性,早期发现,及时进行干预治疗,对减少肝纤维化、肝硬化甚或肝癌的发病率有重要意义。目前,西医对于非酒精性脂肪肝治疗缺乏有效安全药物,而中医药方面许多专家学者通过大量研究发现,祛湿活血方对于治疗非酒精性脂肪性肝病体现出显著的优势。中医治疗该病一直是业内研究热点,现将近年来祛湿活血方治疗非酒精性脂肪性肝病的研究近况进行综述,进而为该病的临床治疗提供新的思路。     

中医药治疗酒精性肝病的研究及思考

目的:为临床提供经验,并为中医药在防治酒精性肝病的方面提供新的研究方向和思路。方法:通过检索中国知网、维普、万方以及Pubmed等数据库,搜索近6年的文献,主要内容包括病因病机、发展、治则方药等。结果:获取大量的文献,再将符合标准的纳入文章中,文章就从其病因病机、治则治法,临床经验及研究等方面进行归纳总结。结论:中医药在治疗酒精性肝病方面前景广阔,有很好的效果,值得再进一步的研究及探索。     

非酒精性脂肪肝中医研究概况

通过分析中医药治疗非酒精性脂肪性肝的相关文献,总结了非酒精性脂肪肝的病因病机,并从辨证分型论治、单味中药、中成药及中医外治等方面论述非酒精性脂肪肝的中医药研究情况,为中医药治疗非酒精性脂肪肝提供一定的资料和依据。     

2型糖尿病合并非酒精性脂肪肝的中医临床研究进展

2型糖尿病合并非酒精性脂肪肝是一种常见病,但其病因病机复杂且临床上难以治愈。近年来,其发病率持续增长且目前西医对该病的治疗尚未有十分确切的方法。中医药治疗该病具有疗效稳定、安全无毒、价格低廉、作用多靶点等优势。文章对近三年来中医治疗2型糖尿病合并非酒精性脂肪肝的相关文献的病因病机和辨证论治、传统中医疗法等方面的研究进行提炼总结,为进一步完善、规范及推广2型糖尿病合并非酒精性脂肪肝的中医药治疗提供参考。     

高原藏族酒精性肝病的临床病理观察

目的：探讨高原藏族酒精性肝病的病理改变特点，并与国内平原和国外者比较。方法 １５０例嗜酒者作肝活检病理观察。结果 分５个病理类型，其基本病变为①肝细胞变性，包括大泡性脂变，灶状小型肝细胞，灶状气球变样；②肝细胞灶状坏死伴中性粒细胞浸润；③窦周纤维化以致发展结节性肝硬变。肝脏的病变程度与饮酒量密切相关，损害程度明显重于国内平原，轻于欧美，与日本相近。结论：与高原缺氧环境、种族差异、喜饮酒及饮食习惯有     

酒精性股骨头坏死中医药临床治疗进展

目前 由于过量饮酒而引起的股骨头缺血性坏死（Avascular Necrosis of the Femoral Head,ANFH）的临床报道越来越多,该病常见于青壮年,致残率高：近年来,祖国医学对酒精性股骨头缺血性坏死进行理论探讨和研究,并结合实践,提出一些较为有效的治疗方法。     

瘦素对非酒精性脂肪肝病的影响

非酒精性脂肪肝病（NAFLD）是一种肝组织病理学改变与酒精性脂肪肝类似但无过量饮酒史的临床综合症状,它的发病机制目前尚不清楚,但瘦素在其中所起到的重要作用受到越来越高的重视：本文就目前国内外瘦素及瘦素抵抗在非酒精性脂肪肝发病中作用的研究现状做一综述。     

疏肝健脾法在非酒精性脂肪肝中的应用概况

非酒精性脂肪肝(NAFLD)是指非酒精性因素造成的脂肪肝,在我国NAFLD的发病率越来越高,同时NAFLD是增加2型糖尿病、心血管疾病和慢性肾病易感性的危险因素,甚至有部分严重者发展成肝癌,随着发病率的增高,NAFLD已成为严重危害人们健康的疾病之一。中医对脂肪肝未有确切的病名,主要是由于脾虚、湿停、气滞、血瘀等引起,并且相互作用,互为影响,笔者回顾近几年治疗非酒精性脂肪肝的国内外文献,发现中医工作者在经过大量的临床研究后,证实了中医在治疗NAFLD中有着独特的优势,其中肝郁脾虚型脂肪肝最为常见,并取得了甚好的疗效,现综述疏肝健脾法在该病的应用。     

A Study of Carotid Atherosclerosis in Patients with Non-alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease shares many features of metabolic syndrome and its presence could signify a substantial cardiovascular risk above and beyond that conferred by individual risk factors. This study is an attempt to investigate the association of non-alcoholic fatty liver disease with carotid intima-media thickness and plaque as surrogate measures of increased cardiovascular risk. The study was conducted on 645 non diabetic, non alcoholic subjects in the age range of 20–60 years. Metabolic syndrome was assessed by using ATP III and ADA (2005) criteria. Anthropometric factors—waist circumference and blood pressure were measured. Fasting serum samples were analyzed for glucose, triglyceride, cholesterol and its fractions, insulin, alanine and aspartate transaminases, gamma glutamyl transferase and free fatty acids. Insulin resistance and secretion were calculated by homeostasis model and insulin sensitivity by QUICKI index. Liver ultrasonographic scanning was used for assessing fatty liver. Carotid atherosclerosis was assessed by B-mode ultrasonography of common carotid artery and internal carotid artery. The prevalence of non-alcoholic fatty liver disease was 15.6 % in non alcoholic population and 68.5 % of non-alcoholic fatty liver disease had metabolic syndrome, which was associated with hyperinsulinemia, insulin resistance, insulin insensitivity along with elevated levels of waist circumference, blood pressure, triglyceride, FFA and decreased HDL cholesterol. NAFLD patients had markedly greater carotid intima media thickness than non NAFLD subjects with MCIMT of 591.6 ± 108 and 489.5 ± 132.4 μm (P < 0.001) and plaque prevalence of 19.2 and 2.2 %, respectively, thus the carotid intima media thickness is associated with NAFLD.     

中西医治疗原发性肝癌的研究进展

原发性肝癌(PLC,简称肝癌)在我国是常见的消化系统恶性肿瘤,其病因复杂,病程进展快,死亡率高.中西医治疗可以优势互补,缓解肝癌患者症状,减少耐药性,降低术后复发率,为肝癌的治疗提供了更加有效的途径与方法.文章查阅近10年中西医治疗肝癌的文献,从中医病名、病因病机、诊断、中医治疗、西医治疗、中西医结合治疗进行综述,以期...     

H型高血压中西医的研究进展

高半胱氨酸血症(hyperhomocysteinemia,HHCY)又称同型半胱氨酸血症,是指血浆中游离的及与蛋白结合的同型半胱氨酸和混合性二硫化物的水平升高[1]。而高血压病伴有同型半胱氨酸血症(≥10 Umol/L)的患者又称之为H型高血压。文章通过整理归纳H型高血压的中西医研究进展,为将来H型高血压的研究找到一个方向。     

中医治疗老年抑郁症的研究进展

老年抑郁症是老年人常见的精神障碍性疾病,严重影响老年人的身心健康及生活质量,加重家庭和社会的负担.随着老年人口的增长,患病率也逐年上升,则引起了医学界多该疾病的高度重视.中医药治疗老年抑郁症不良反应小,安全可靠,具有明显的临床疗效.文章着重从中医的病因病机、辨证分型、治疗等方面进行阐述老年抑郁症的治疗思路,为临床上治疗...     

中医药治疗癫痫的研究进展

癫痫是以突发意识障碍、四肢抽搐为主要临床表现的一种神经系统慢性疾病.目前其发病机理尚不明确,而西药治疗是癫痫的主要手段,但西药治疗毒副作用大,且治疗周期较长.近年来随着中医药的不断发展,发现中医药在治疗癫痫方面具有独特的优势,因其疗效肯定且毒副作用小越来越被患者接受.为探讨相关中医药疗法在癫痫的研究进展,笔者通过查阅相...     

中医针灸治疗痛症的研究进展

中医针灸作为我国传统医学文化中的瑰宝,临床应用广泛,内、外、妇、儿均适合使用,并且简便廉验,安全高效.痛症作为一种临床常见病,也是一种急症,给患者带来了极大的痛苦和折磨,快速安全有效的止痛是患者的强烈愿望,也是医生诊治过程中的主要选择策略之一.随着中医针灸在临床实践上的不断深入,发现中医针灸对痛症有着良好的止痛效果.因...     

Biochemical Evaluation of Patients of Alcoholic Liver Disease and Non-alcoholic Liver Disease

Alcoholic liver disease (ALD) is due to excessive alcohol intake for long duration. Distinguishing ALD from non-ALD (non-alcoholic steatohepatitis, hepatitis of viral origin) is difficult as patient may deny alcohol abuse. Clinical examination, histology and serology may not differentiate these conditions. Accurate diagnosis is important as management of ALD differs from non-ALD patients. The aim of our study was (1) To evaluate the patients of ALD and non-ALD by biochemical parameters compared to controls, (2) To assess whether these parameters can differentiate ALD from non-ALD. Study was carried out on 50 patients of ALD in group I and 35 patients of NASH (non-alcoholic steatohepatitis) and acute viral hepatitis each in group II. Age matched healthy controls n = 50. Selection criteria—history of alcohol intake (amount and duration), clinical examination, sonography of abdomen, serum alanine transaminase (ALT) and bilirubin levels. Blood samples were analyzed for bilirubin, aspartate transaminase (AST), ALT, alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) by kinetic method. Statistical analysis was done by Student unpaired ‘t’ test. Patients of ALD have raised AST/ALT ratio (De Ritis ratio) (>2), ALP and GGT compared to controls (P < 0.01).There is significant difference in AST/ALT ratio, serum GGT and ALP in ALD group compared to that in NASH and acute viral hepatitis (P < 0.05). This study suggests that De Ritis ratio >2 in ALD patients may be due to alcohol induced hepatic mitochondrial injury and pyridoxine deficiency. High GGT and ALP values may indicate enzyme induction by alcohol and mild cholestasis. Thus ALD patients have severe hepatic damage. De Ritis ratio <1 and normal to mild elevation in GGT level in NASH and acute viral hepatitis suggest mild hepatic injury of non-alcoholic origin. Our study concludes that ALD patients can be differentiated from NASH and acute viral hepatitis with certainty by measuring serum AST/ALT ratio, GGT and ALP. These biochemical parameters may help clinicians to support the diagnosis of ALD and non-ALD.     

中医治疗男性不育症的研究进展

男性不育症是最常见的男性生殖系统疾病之一,近年来中医药在防治男性不育症方面取得较好效果.文章回顾了近年来国内中医药对男性不育症病因病机的相关研究报道,如从脏腑气血津液、湿、热、痰、瘀、虫,辨病与辨证、微观与宏观,中医体质等角度认识,旨在为中医药治疗男性不育症提供一定的理论依据与参考.