带蒂大纲膜包肾防治肾小球硬化的实验研究

为探讨带蒂大纲膜包肾术防治肾小球硬化的作用，采用单侧肾切除加二次注射阿霉素剂备的肾小球硬化动物模型，观察带蒂大纲膜包肾对肾脏的作用，结果表明，带蒂大纲膜包肾可降低血胆固醇、甘油三脂、尿蛋白排泄、肾小球球囊粘连减轻，血尿素氮有下降趋势，说明带蒂大纲膜包肾术对肾小球硬化大鼠的肾脏损伤有保护作用。     

Effect of Isoproterenol on Tissue Defense Enzymes,Hemodynamic and Left Ventricular Contractile Function in Rats

Present study investigated the effects of isoproterenol-induced oxidative stress on hemodynamic and ventricular functions in rats. Subcutaneous injections of isoproterenol (85 mg/kg for two consecutive days at 24 h interval) significantly decreased myocardial antioxidant enzymes; superoxide dismutase, catalase and glutathione peroxidase in heart. Isoproterenol-induced oxidative stress was also evidenced by significant depletion of reduced glutathione and increased formation of lipid peroxidation product, thiobarbituric acid reactive substances along with depletion of myocyte injury specific marker enzymes; creatine phosphokinase isoenzyme and lactate dehydrogenase. The deleterious outcome of oxidative stress on hemodyanmic parameters and ventricular function were further evidenced by decreased systolic, diastolic and mean arterial blood pressure, heart rate, ventricular contractility; [(+)LVdP/dt] and relaxation; [(−)LVdP/dt], along with an increased left ventricular end diastolic pressure (LVEDP). Subsequent to changes in heart rate and arterial pressure, isoproterenol also decreased rate pressure product. Present study findings clearly demonstrate the detrimental outcome of isoproterenol induced-oxidative stress on cardiac function and tissue antioxidant defense and substantiate its suitability as an animal model for the evaluation of cardioprotective agents.