Scientific Evaluation with the Help of International Experts

A n11-memberpanelfinished its assessmentof fiveinsti- tutesundertheCASShang-haiInstitutes for BiologicalSciences(SIBS) onApril7inShanghai. The scientific evaluationcommittee, headed by Lap-CheeTsui, CAS Member and Vice Presi-dentoftheUniversityofHongKong,consists of renowned experts fromthe US, Germany, Japan, Israel andChina. Two of themare NobelPrizelaureates:Prof.Torsten Wiesel,1981NobelPrizewinner in physiology ormedicine, andProf.HartmutMichel,win…     

Regulations on Protection of Products with Geographic Indications

(Promulgated on 16 May 2005 by the General Administration of Quality Supervision, Inspection and Quarantine of People's Republic of China) Chapter I General Provisions Article 1 These Regulations have been formulated with a view to effectively protecting products with geographic indications, standardising the use of the names of the products and use of geographic indications, and to ensuring the quality and special features of the products with geographic indications under the relevant regulations, such as the Product     

A Case Report of a 14?Year Old Male with Pseudohypoparathyroidism Associated with Multiple Hormonal Resistance

Albright hereditary osteodystrophy (AHO) is a rare hereditary metabolic disorder that may or may not be associated with resistance to parathyroid hormone (pseudohypoparathyroidism) or other hormones. The disorder is commonly characterized by a constellation of dysmorphic physical features and with biochemical levels that demonstrate hypocalcaemia and hyperphosphatemia. We report here a clinical case of a 14 year old male with AHO and we discuss his clinical features, radiographic and laboratory findings along with treatment.     

Are intellectual property rights compatible with Rawlsian principles of justice?

This paper argues that intellectual property rights are incompatible with Rawls’s principles of justice. This conclusion is based upon an analysis of the social stratification that emerges as a result of the patent mechanism which defines a marginalized group and ensure that its members remain alienated from the rights, benefits, and freedoms afforded by the patent product. This stratification is further complicated, so I argue, by the copyright mechanism that restricts and redistributes those rights already distributed by means of the patent mechanism. I argue that the positions of privilege established through both the patent and the copyright mechanisms are positions that do not “allow the most extensive liberty compatible with a like liberty for all.” They do not “benefit the least advantaged.” Nor are they “open to all under conditions of fair equality of opportunity.” In making this argument I critically assess the utilitarian defense of intellectual property rights and find it insufficient to respond to the injustices manifest in our current arrangement for the protection of intellectual property rights.     

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.     

The Legend of LIGO——An Interview with David Reitze

<正>As the most expensive project ever funded by the U.S.National Science Foundation,the Laser Interferometer Gravitational-Wave Observatory(LIGO)aims at fully testing the existence of gravitation waves predicted by Albert Einstein and opening a new gateway for astronomers and physicists alike to explore the universe.In April,2015,during his stay in Beijing for"The Next Detectors for Gravitational Wave Astronomy"     

Impairment of Mitochondrial–Nuclear Cross Talk in Neutrophils of Patients with Type 2 Diabetes Mellitus

Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that mitochondrial deregulation in neutrophils perturbs immunological balance in type 2 diabetic conditions. By virtue of our data, we posit that maneuvering mitochondrial function might offer a prospective and viable method to modulate neutrophil function in T2DM. Nevertheless, similar investigations from other ethnic groups in conjunction with experimental evidences would be a preeminent need. Obviously, our study might aid to comprehend this complex interplay between mitochondrial dysfunction and neutrophil homeostasis in T2DM.     

The foundations of Israel’s ongoing love affair with science

During the last two decades, the history of science in Israel has attracted much scholarly attention. Historians of science, science and technology studies (STS) scholars, and Middle East/Israel studies experts have focused on specific scientific disciplines or periods, analyzing the uniqueness of science and technology in Israel. This article explores what characterized Israel’s scientific activity precisely at the time of the state’s birth, and examine how the perception of science as key to Israel’s survival was constructed and reinforced in that formative phase. The focus here is on the natural sciences, as the perception of the natural sciences’ importance and their contribution to building the state and its security differed essentially from that of other disciplines. As this article demonstrates, the challenges that the natural sciences faced during Israel’s War of Independence were far more difficult than those faced by the social sciences and the humanities. This study analyzes scientific activity that took place in one single year, beginning with the establishment of the Science Corps in March 1948, two months before Israel’s declaring independence, until the end of its War of Independence in February 1949. As this study shows, both the war effort and the civilian activities strongly influenced scientific research and implementation in the nascent state.     

CAS Embraces Era of Multi-messenger Astronomy with Successful Launching of “Huairou-1” Twin Satellite

<正>Named "Huairou-1",a small pair of micro-satellites quietly embarked on a ground-breaking journey.The twin was thrown into the sky at 4:14 am (GMT+8) of December 10, 2020 from the Xichang Satellite Launch Center in Northwest China,and successfully entered the preset orbit.     

The approximation of the T–S fuzzy model for a class of nonlinear singular system with derivative of input

In this paper, the approximation problem of T–S fuzzy linear singular system for a class of nonlinear singular system with derivative of input is considered and the nonlinear singular system has impulses. Consider a numerical example and a two-wheel drive robot, the T–S fuzzy singular systems are calculated for original system with derivative of input. According to solvability and steps of solving of the two examples, the results are extended to more generally nonlinear singular system with derivative of input. The theorem and algorithm that are given if input-state system is bounded impulse-free item and separable impulse item, it can be approximated by T–S fuzzy singular system with arbitrary accuracy. Finally, a numerical simulation is carried out to show the consistency with theoretical analysis and illustrate the effectiveness of approximation.     

ISS control synthesis of T–S fuzzy systems with multiple transmission channels under denial of service

This paper investigates the input-to-state stabilizing (ISS) problem for Takagi–Sugeno (T–S) fuzzy systems with multiple transmission channels under denial-of-service (DoS) attacks. To achieve ISS, time-triggered data update logics on different channels are determined by linear matrix inequalities (LMIs). Under DoS attacks, a switched fuzzy dynamic output feedback controller which takes the security of premise variables into consideration is constructed. A novel time division mechanism is proposed to deal with the uncertainties caused by DoS attacks at different time periods. The proposed mechanism considers all cases of DoS attacks, which is more general compared to the existing method. Then, sufficient conditions are given to ensure the ISS of T–S fuzzy systems under DoS attacks. Finally, two examples are given to illustrate the effectiveness and merits of the proposed method.     

Citizens of somewhere: Examining the geography of foreign and native-born academics’ engagement with external actors

This paper explores the geography of academic engagement patterns of native and foreign-born academics, contrasting how patterns of intranational and international engagement with non-academic actors differ between these two groups. We suggest that foreign-born academics will engage more internationally than their native-born colleagues, whereas native-born academics will have greater levels of intranational engagement. Drawing upon a large multi-source dataset, including a major new survey of all academics working in the UK, we find support for the idea that where people are born influences how they engage with non-academic actors. We also find that these differences are attenuated by an individual’s intranational and international experience, ethnicity and language skills. We explore the implications of these findings for policy to support intranational and international academic engagement.     

Formation,Evolution of Tibetan Plateau with Its Environment and Resource Effects

The Tibetan Plateau (the Qinghai-Tibet Plateau) is a unique geographical region with the highest elevation, and the only existing theater of tectonic collision now still in action on the earth. The continuous rapid uplifting of the landmass beneath the Plateau in the     

Engaging excellence? Effects of faculty quality on university engagement with industry

We investigate how universities’ research quality shapes their engagement with industry. Previous research has predominantly found a positive relationship between academics’ research quality and their commercialization activities. Here we use industry involvement measures that are broader than commercialization and indicate actual collaboration, i.e. collaborative research, contract research and consulting. We hypothesise that the relationship between faculty quality and industry engagement differs across disciplines, depending on complementarities between industrial and academic work, and resource requirements. Using a dataset covering all UK universities, we find that in technology-oriented disciplines, departmental faculty quality is positively related to industry involvement. In the medical and biological sciences we find a positive effect of departmental faculty quality but establish that this does not apply to star scientists. In the social sciences, we find some support for a negative relationship between faculty quality and particularly the more applied forms of industry involvement. The implication for science policy makers and university managers is that differentiated approaches to promoting university-industry relationships are required.     

Research undertaken by CAS scientists with support of "973 Program"

The National Basic Research Program (dubbed as the " 9 73 Program" is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1997 and is organized and implemented by the Ministry of Science and Technology. The strategic objectives of the Program are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a deeper level and in a wider scope, so as to improve China's capabilities of independent innovations and to provide scientific support for the future development of the country. The followings are some of the" 9 73 projects" initiated in 2006 under the coordination of CAS scientists.     

Input-to-state stability of switched stochastic delayed systems with Lévy noise

This paper focuses on input-to-state stability of a class of switched stochastic delayed systems which are drived by Lévy noise. By multiple Lyapunov function and average dwell time approach, the sufficient conditions of the ψ^λ(t)-weighted input-to-state stability can be obtained if all the subsystems are input-to-state stable. Then utilizing comparison principle and the method of constant variation, the sufficient criteria of the e^λt-weighted input-to-state stability of the switched stochastic delayed systems containing both input-to-state stable subsystems and non-input-to-state stable subsystems can also be derived. Finally, an example is given to illustrate the effectiveness of the proposed results.