共查询到20条相似文献,搜索用时 31 毫秒
1.
Ajai Kumar M. C. Pant H. N. Pandey J. L. Aggarwal R. S. Sharma L. D. Joshi S. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):47-50
Effect of feeding ripe and unripe papaya fruit pulps were investigated on blood lipid profile of normal male adult albino rabbits by giving them pulps separately at the dose of 15 and 30g per day along with standard diet over a period of six weeks. As compared to controls both fruit pulps resulted in highly significant (p<0.001) and consistent lowering of serum cholesterol, low density lipoprotein cholesterol and triglycerides and elevation in phospholipids and high density lipoprotein cholesterol levels at 1,3 and 6 weeks of fruit pulp feeding indicating a dose dependent effect. Observations clearly support medicinal value ofC. Papaya in the management of atherosclerosis, fatty liver, ischaemic changes and consequential myocardial infarction. 相似文献
2.
Sangeeta Agnihotri S. B. Pachori D. N. Pandey M. C. Pant 《Indian journal of clinical biochemistry : IJCB》1990,5(2):91-94
The effects of regular feeding ofPyrus malus whole fruit and its juice on total serum cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and phospholipids have been studied in normal albino rabbits. It was observed that the whole fruit as well as juice caused significant and progressive decrease in total serum cholesterol, LDL cholesterol and triglycerides within a period of 30 days. On the other hand, serum phospholipids and HDL cholesterol showed progressive and significant increase. Apparently, whole fruit appeared to bring about more per cent lowering in total cholesterol, LDL cholesterol and more increase in HDL cholesterol as compared to juice. Whole apple fruit also caused increase in body weight of rabbits on 30th day (p<0.05) while oral administration of juice showed insignificant change in body weight even on 30th day (p>0.05). 相似文献
3.
K. A. Faseehuddin Shakir Basavaraj Madhusudhan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):117-121
Rats fed with hypercholesterolemic diet showed a significant increase in serum total—cholesterol, liver homogenate total-cholesterol,
HDL-cholesterol and changed LDL-cholesterol, and HDL/LDL ratio in comparison to control. Flaxseedchutney (FC) supplemented diet (15%, w/w) was found to be more effective in restoring lipid profile changes in rats fed with cholesterol,
(1.0%). The activities of serum marker enzymes glutamate oxaloacetate transminase (GOT), glutamate pyruvate transaminase (GPT)
and alkaline phosphatase (ALP) were elevated significantly in carbon tetrachloride induced rats. Administration of flaxseedchutney (15%, w/w) resulted in depletion of serum marker enzymes and exhibited recoupment thus showing significant hepatoprotective
effect. It was observed that flaxseedchutney supplemented diet could lower the serum cholesterol and as a potential source of antioxidants it could exert protection against
hepatotoxic damage induced by carbon tetrachloride (CCl4) in rats. 相似文献
4.
Aarti Sankhla P. N. Mathur A. K. Sankhla P. K. Dashora 《Indian journal of clinical biochemistry : IJCB》1992,7(2):155-158
In a four weeks study, Aesculus hippocasteneum, a known homeo herbal slimming agent was administered at a dose of 3 drops/100
ml water to adult Wistar rats fed on Hypercholesterolemia inducing diet (HID). It successfully inhibited the rise in serum
total cholesterol (TC) and simultaneously raised serum HDL-cholesterol (HDL-C). It was also effective in reducing serum triglyceride
level (TG), whereas it failed to affect serum phospholipid (PL), liver cholesterol, liver weight and body weight of the experiment
animals. 相似文献
5.
Murooj L. Majeed Fadhaa A. Ghafil Ghizal Fatima Najah R. Hadi Hind F. Mahdi 《Indian journal of clinical biochemistry : IJCB》2021,36(1):74
Curcumin has a potent antioxidant and anti-inflammatory properties that may suppress inflammatory component of atherosclerosis. It has been demonstrated that curcumin derivatives can reduce the formation of arterial fatty streaks in cholesterol-fed rabbits. Therefore in this study we evaluated the protective effects of Curcumin on the progression of atherosclerosis. 20 mature rabbits were included for this study; they were randomly divided into four groups each of 5. Group 1: (normal control) were fed corn pellets diet and tab water, group 2: (high cholesterol diet control) were kept on cholesterol rich diet (2% cholesterol) and tab water. Group 3: (cholesterol and rosuvastatin treated group) were kept on cholesterol rich diet (2% cholesterol) and 2.5 mg/kg/day Rosuvastatin dispersed in DW and given orally, group 4: (cholesterol and curcumin treated group) were kept on cholesterol rich diet (2% cholesterol) and 0.2% curcumin added with corn pellets. The study continued for 12 weeks then assessment of serum level of high sensitive C-reactive protein, ICAM1, VCAM1 and PCSK9 was carried out at the end of the study. Total antioxidant activity of curcumin was also determined. Histopathological examination of aortic tissues for atherosclerotic changes was also carried out. Atherogenic (cholesterol rich diet) induced an increment in serum level of TC, LDL, VLDL and TG with concomitant decrement in serum level of HDL and increased atherogenic index. Treatment with curcumin produced substantial reduction in serum TC, LDL, TG with no effect on HDL level thus decreased atherogenic index. Rabbits treated with curcumin showed a significant reduction in the serum level of high sensitive C-reactive protein, ICAM1, VCAM, PCSK9 serum expression and aortic total antioxidant capacity. Curcumin has a potent anti-inflammatory and anti- oxidant effects against atherosclerosis so exerts a protective role by decreasing lipid oxidation and inflammatory markers. 相似文献
6.
Jerry Joseph Emanuel Dickson M. B. Kadam P. K. Joseph 《Indian journal of clinical biochemistry : IJCB》1991,6(1):27-29
Rats were fasted for 8 hours and then fed 3 ml of 25% (v/v) ethanol per 100g body weight and subsequently sacrificed 18 hours
later. The levels of triacylglycerols and total cholesterol were significantly raised in serum and liver of alcohol fed rats.
However, when rats were fed on aqucous extract of onions (300 mg per 100g body weight) with 25% ethanol, no rise in serum
and liver lipids was observed. Alcohol fed to the fats with or without onion extract had no effect on serum, AST, ALT and
alkaline phosphatase levels. The increase in serum urea in ethanol-fed rats was not altered in rats fed a mixture of alcohol
and onion extracts. Values of liver MDA was lower in rats fed ethanol with or without onion extract compared to controls.
Onion extract seemed to show a hypolipidemic effect in alcohol fed rats. 相似文献
7.
A. Bhise P. V. Krishnan R. Aggarwal M. Gaiha J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2005,20(2):4-9
The present study comprised 100 patients of essential hypertension who were screened for fasting hyperinsulinemia, which was
detected in 77% cases. Twenty such hyperinsulinemic cases were subjected to 4 weeks of dietary control phase followed by 6
weeks of omega-3 fatty acids substitution [either 0.6 g/d (group 1) or 1.2 g/d (group 2)]. The mean basal fasting plasma insulin
levels were significantly higher (p<0.001) in patients of hypertension when compared to normal controls (126.51±80.36 and
19.35±12.61 μU/ml respectively). At the end of 4 weeks of diet control only, no significant change was observed in any parameter.
After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and
group 2 (22.8%) was observed (p<0.001). Significant reduction of systolic and diastolic blood pressure (16.4% and 25% respectively),
serum cholesterol, triglycerides and low density lipoprotein was also noted in both groups (p<0.001), while high density lipoprotein
increased by ∼8 mg% in both groups. Thus omega-3 fatty acid substituion in low dose along-with curtailment of dietary omega-6
fatty acid may be used as an adjunctive measure in the management of essential hypertension. 相似文献
8.
An experimental model of hypercholesterolemic rabbits suitable for studying the hypocholesterolemic effect of compounds was
developed. Rabbits were made hypercholesterolemic by oral administration of cholesterol (100mg/kg body weight/day) suspended
in groud nut oil by gastric intubation (Ryle's tube). Cholesterol can be given to rabbits from 10 days to 6 months depending
on the degree of hypercholesterolemia required and duration of study of hypocholesterolemic effect. In one month cholesterol
feeding experiment, the serum cholesterol level in normal controls (not given cholesterol) was 67±11.3 mg/dl and in cholesterol
fed animals 191.3±70.6 mg/dl. In 2 months experiment, besides hypercholesterolemia, abnormal serum lipid profile and increase
in lipid content in liver, heart and aorta were also seen. To such animals when water and methanol extracts of garlic were
given along with cholesterol, there was significant decrease in serum cholesterol level. The advantage of this method over
the method in which cholesterol is mixed with diet to induce hypercholesterolemia is that exactly same and calculated amount
of cholesterol can be given for each animal. This minimises the variations in serum cholesterol levels in different animals. 相似文献
9.
The objective of the present study was to evaluate hypolipidemic effect of methanolic extract of Celastrus paniculatus in experimentally induced hypercholesterolemic rats. Hypercholesterolemia was induced by feeding the animals with high fat
diet. Oral administration of methanolic seed extract (50%) of Celastrus paniculatus at the optimized dose of 65 mg/kg body weight, substantially reduced the plasma total cholesterol, triglycerides and LDL
cholesterol in comparison with induced hypercholesterolemic animal group and the results were comparable with the standard
hypocholesterolemic drug and almost similar to the control group. Atherogenic index and liver weight of treated animals also
showed significant decrease compared to the hypercholesterolemic animals. It substantially increased the HDL cholesterol level
as compared to control group. A significant increase in the activities of lipoprotein lipase and plasma LCAT enhanced hepatic
bile acid synthesis and thereby, increased degradation of cholesterol to neutral sterols. Furthermore, the activities of HMG-CoA
reductase, glucose 6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Histological studies showed
less cholesterol deposits in the aorta of animals fed with seed extract of C. paniculatus compared to the induced hypercholesterolemic animals not given C. paniculatus supplement. 相似文献
10.
M. Cariappa K. Poornima M. Nandini K. Asha H. P. Kedilaya 《Indian journal of clinical biochemistry : IJCB》2005,20(1):103-108
Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However
the beneficial effects of fish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation.
It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant
status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population
consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of
23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and
the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and triglycerides (TG). Statistical analysis was
carried out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various
lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain
altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly
in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other. 相似文献
11.
Maninder Kaur Kiranjeet Kaur Gurdeep Kaur Bedi Gurpreet Singh Sidhu Roopan Sikand 《Indian journal of clinical biochemistry : IJCB》2000,15(2):63-67
Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed
before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically
significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation
was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range
of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol,
serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive
patients in a positive way. 相似文献
12.
Priyanka Surana Aarti Sankhla P. K. Dashora 《Indian journal of clinical biochemistry : IJCB》2000,15(2):167-170
To examine the effect of “DeepaniyaVati”, a herbal formulation in the management of hyperlipidemia, a randomized group pre-test
post-test study trial was carried out on fifty male (30 to 70 yrs) hyperlipidemic volunteers who were asked to follow their
normal routine diet and activity pattern throughout the investigation period. The formulation, prepared by mixing nine plant
products in equal proportion, when given in a daily dose of 2g, twice a day for a period of one month, brought about an observable
improvement in all the lipid parameters by significantly reducing total cholesterol (10%), low density lipoprotein cholesterol
(12.76%), very low density lipoprotein cholesterol (27.4%), triglycerides (34.7%) and bringing these values much nearer to
the normal levels. In control group, no such effect was noticed. A concomitant significant increase in the HDL-C levels suggests
the possible utility of “Deepaniya Vati” in the management of hyperlipidemia and the need for further detailed study. 相似文献
13.
A. Ray S. L. Dayalu Naik A. K. Bahadur S. T. Pasha R. S. Rautela B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):101-105
Serum levels of various lipid parameters, i.e., triglycerides, total cholesterol, alpha lipoprotein or high density lipoprotein
(HDL)-cholesterol and beta lipoprotein or low density lipoprotein (LDL)-cholesterol were measured in a total of 138 histologically
proven cases of breast cancer along with 146 control women. The mean levels of serum triglycerides, total cholesterol and
LDL-cholesterol were found to be significantly higher in breast cancer cases as compared to controls. However, lower mean
levels of serum HDL-cholesterol and sex-hormone binding glubulin (SHBG) were observed in breast cancer patients than the control
subjects. The results indicate a probable relation between serum lipids and the activity of sex-hormones. Moreover, the study
reflects an overall disturbance of lipid metabolism in the pathological process of breast cancer. 相似文献
14.
Vaneet Kaur Minni Verma Amandeep Kaur Shalini Gupta Kamaljit Singh 《Indian journal of clinical biochemistry : IJCB》2012,27(3):290-295
Overnight fasting samples of 1,031 apparently healthy people of Punjab visiting the hospital over a period of 3 years were tested for serum lipid profile. The mean ± SD of serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol in mg/dl were 182.2 ± 33.9, 122.4 ± 33.4, 44.1 ± 6.8, 113.9 ± 32.0, 24.6 ± 7.1 respectively. When these subjects were grouped according to age and sex, no appreciable difference was observed between most of the groups. Serum triglycerides were found to be low and HDL-C was high in females when compared with males of similar age and vice versa. With advancing age, total cholesterol and low density lipoprotein cholesterol levels were found to be higher in women. The present study suggests that the obtained lipid values should be taken into consideration during clinical evaluation. 相似文献
15.
P. P. Naik M. S. Ghadge A. S. Raste 《Indian journal of clinical biochemistry : IJCB》2006,21(2):100-102
A number of epidemiologic studies has been published in recent years showing an increase risk of death from cancer in subjects
with low plasma cholesterol levels. Although several authors proposed that hypocholesterolemia is predisposing factor for
cancer development, no causative relation has been established so far and that it may be that low plasma cholesterol is secondary
to malignant disease. Hence, the present study was undertaken to examine the lipid profile in children patients with leukemia
and Hodgkin's disease in comparison with age matched controls. The study included 52 normal healthy controls and 105 patients
with leukemia and Hodgkin's disease. Lipid profile included serum cholesterol, HDL & LDL cholesterol and triglycerides. Serum
cholesterol, HDL & LDL cholesterol were found to be inversely associated with incidence of cancer, whereas triglycerides were
significantly elevated in cancer patients. The inverse association between cancer and serum cholesterol may reflect a physiological
response to early undiagnosed stages of cancer. 相似文献
16.
Effects of three drugs, Gemfibrozil, Diltiazem and lsosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and incroased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease. 相似文献
17.
C. I. Jhala U. V. Shah T. K. Shah B. K. Naik J. D. Dafda 《Indian journal of clinical biochemistry : IJCB》1998,13(1):1-7
Fasting samples of 1329 apparently healthy vegetarian Gujarati population were tested for total cholesterol, triglycerides
and three major fractions of lipoproteins, i.e. high density lipoproteins, low density lipoproteins and very low density lipoproteins.
All the values showed marked increase with the age. Except for serum triglycerides, values differ in males and females in
the age group of above 45 years. Compared to Northern Indian population low density lipoprotein and high density lipoprotein
values were higher, but values of triglycerides and very low density lipoproteins were lower. There is no significant difference
in total cholesterol values. Compared to Southern Indian population low density lipoprotein and very low density lipoprotein
values were higher but values of triglycerides, total cholesterol and high density lipoprotein were lower. All serum lipid
values were significantly lower than the Westem population. The range of values for both the sexes is presented for different
age groups. 相似文献
18.
Waleed Tamimi Esam Albanyan Yasmin Altwaijri Hani Tamim Fahad Alhussein 《Indian journal of clinical biochemistry : IJCB》2012,27(2):141-146
Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6–7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations. 相似文献
19.
Santosh C. Das Aminu Z. Mohammed Sani U. Al-Hassan Abraham A. Otokwula Uche P. Isichei 《Indian journal of clinical biochemistry : IJCB》2007,22(2):79-83
In order to see the pattern of changes in differential serum lipid and lipoprotein fractions as a risk marker of coronary
complication in paired ‘maternal—neonate’ blood samples in an iodine deficient zone, 26 pregnant women and their corresponding
new born infants at term delivery from the iodine deficient Bassa region of Plateau state, Nigeria were assessed and the results
were compared with those seen in a similar 44 group of women and their newborns assessed in non lodine deficient region of
Jos. The serum thyroid function and lipid and lipoprotein profiles were determined by ‘ELISA’ and ‘enzymatic’ methods respectively.
Urinary iodide excretion level was also measured in 14 pregnant women in Bassa, 23 pregnant women in Jos and 16 non pregnant
control from Jos. Results indicate that the pregnant women assessed in Bassa were iodine deficient (P<0.01) and their thyroid
status was strikingly reduced as reflected by a drop in serum level of T4/TBG ratio (P<0.01) and a rise in TSH (P<0.005) in
comparison to that seen in Jos. There was marked hypertriglyceridaemia and total hypercholesterolaemia (P<0.005), with differential
significant rise in LDL cholestotol fraction (P<0.005) in the women assessed in Bassa as compared to Jos. The HDL cholesterol
however dropped less significantly in the group (P<0.05) with a concurrent marked rise (P<0.001) in the serum ratio of LDL
cholesterol/HDL cholesterol, total cholesterol/HDL cholesterol and triglycerides/HDL cholesterol in the lodine deficient group.
A similar pattern of changes were seen in the corresponding neonates in the Bassa group as compared to Jos group. It is concluded
that the pregnant women and their newborn offsprings living in a longstanding environmental iodine deficiency run a higher
risk of developing coronary complications than those living in non endemic region. It is striking that such newborns surrounded
by a continued state of lodine deficient may at a later adult-period of life develop marked risk of coronary complication
and other features of hyperlipidaemias associated with varying thyroid insufficiency and accompanied iodine deficiency disorders.
Prophylaxis measures as intervention has been highlighted. 相似文献
20.
P. J. Benny G. Muraleedhara Kurup K. Sreejith 《Indian journal of clinical biochemistry : IJCB》1997,12(2):108-113
The anticancerous drug isolated in our laboratory from estuarineAeromonas was characterised and is found to be an enzyme, L-asparaginase. The antileukaemic effect of this drug was studied in mice
by inducing leukaemia with Ehrlich ascites cell lines. It was compared with commercially available drug, Leunase, isolated
fromE. coli. The lipid profiles in mice during leukaemia and under treatment was studied. The decreased levels of cholesterol and increased
levels of triglycerides and phospholipids in serum, liver and kidney were observed in tumour bearing mice. Significant changes
in the above values were observed with enzyme therapy. It could bring some of the values to near normal level. L-asparaginase
fromAeromonas was found to be more effective. 相似文献