Molecular biomarkers of colorectal cancer: prognostic and predictive tools for clinical practice

Colorectal cancer remains one of the most common types of cancer and leading causes of cancer death worldwide. Although we have made steady progress in chemotherapy and targeted therapy, evidence suggests that the majority of patients undergoing drug therapy experience severe, debilitating, and even lethal adverse drug events which considerably outweigh the benefits. The identification of suitable biomarkers will allow clinicians to deliver the most appropriate drugs to specific patients and spare them ineffective and expensive treatments. Prognostic and predictive biomarkers have been the subjects of many published papers, but few have been widely incorporated into clinical practice. Here, we want to review recent biomarker data related to colorectal cancer, which may have been ready for clinical use.     

The association of intrafamilial violence against children with symptoms of atopic and non-atopic asthma: A cross-sectional study in Salvador,Brazil

This study aims to describe the types of intrafamilial violence perpetrated against children according to living conditions, family factors, and child characteristics, and to identify the association between types of intrafamilial violence and asthma symptoms in atopic and non-atopic children. A cross-sectional study was carried out with 1,370 caregivers as part of the Social Changes, Asthma and Allergy in Latin America (SCAALA) study, conducted in 2006 in Brazil. The study population was selected by random sampling. The main outcome measures were atopic and non-atopic asthma. We investigate the association between intrafamilial violence and asthma symptoms in atopic and non-atopic children. A backward multivariate logistic polytomous regression was performed to verify the main association. Nonviolent discipline (NVD) and maltreatment nonviolent discipline (MNVD) were positively associated with non-atopic asthma symptoms (NVD: odds ratio (OR) = 1.95/95% confidence interval (CI) = 1.17–3.25; MNVD: OR = 1.95/95% CI = 1.19–3.20). However, for the most severe intrafamilial violence, this association was not found after control of potential confounders. This study demonstrates the effect of types of intrafamilial violence on non-atopic asthma. Intrafamilial violence against children represents one more component in the determination of non-atopic asthma in Latin America.     

RNA interference against interleukin-5 attenuates airway inflammation and hyperresponsiveness in an asthma model

Interleukin-5 (IL-5) accompanies the development of airway inflammation and hyperresponsiveness through the activation of eosinophils. Therefore, interference of IL-5 expression in lung tissue seems to be an accepted approach in asthma therapy. In this study, we designed a small interfering RNA (siRNA) to inhibit the expression of IL-5. The siRNAs against IL-5 were constructed in a lentivirus expressing system, and 1.5×106 IFU (inclusion-forming unit) lentiviruses were administered intratracheally to ovalbumin (OVA)-sensitized murine asthmatic models. Our results show that lentivirus-delivered siRNA against IL-5 efficiently inhibited the IL-5 messenger ribonucleic acid (mRNA) expression and significantly attenuated the inflammation in lung tissue. Significant decrease of eosinophils and inflammatory cells were found in peripheral blood, bronchoalveolar lavage fluid (BALF), and lung tissue. In addition, significant inhibition of airway hyperresponsiveness (AHR) was found in the mice treated with siRNA against IL-5. These observations demonstrate that siRNA delivered by means of the lentivirus system is possibly an efficacious therapeutic approach for asthma.     

民族传统体育的重塑与改造

分析论述了民族传统体育重塑与改造的社会历史和文化背景及现代意义,提出民族传统体育重塑与改造,必须以现代体育思想为指导,以承担社会功能为出发点,以提高应用价值为目的,坚持服务于社会、服务于人的原则,运用科学的理论与方法,才能实现民族传统体育真正意义的复兴.     

学校生活中教师权威的退隐及其重塑

随着信息技术和网络文化的发展、构建新型师生关系的诉求以及教学模式的"程序化"使用等,教师传统的知识权威、角色权威和感召权威呈现出退隐形态。但在学校生活实践场域,学生的年龄特征和成熟度呼唤教师的智慧权威;师生关系民主化要求重新解读教师的角色权威;课堂教学的深度变革需要教师继续发挥感召权威。这些赋予了教师权威存在的合理性价值。鉴于此,拟尝试通过"外发型"法理性权威与"内生型"专业性权威这两种路径来实现教师合理性权威的重塑。     

试析新媒体时代传统文学名著之影视化重塑

新媒体时代传统的文学名著受到了极大的冲击,其生存状况堪忧,应该给予极大重视.文章分析了新媒体、影视等相关概念,并从新媒体时代传统文学名著的生存危机、文学名著与影视剧的联姻关系、文学名著的影视化重塑之深层动因以及改编后文学名著的生存状态等方面探讨传统文学名著的影视化重塑.     

原体验设计在品牌重塑中的表达与应用

以原体验设计在品牌重塑中的应用为主线,提出依靠原体验设计提升消费者对品牌的信任度及购买动机的观点,并深入探讨原体验设计一系列的应用模式。     

家族文化与20世纪中国文学的变迁——评《家族文化与20世纪中国家族文学的母题形态》

家族文化在传统文化体系中占有重要地位，20世纪中国文学在一定程度上折射了家族文化的精神特质，两者的互映互动延续了整个20世纪中国文学的发展历程。以文学母题为基点，将百年中国文学置于“家园皈依意识与追寻母题”、“男权制文明与审父母题”、“重返母体与失乐园母题”、“宗法血缘秩序与乱伦母题”和“家族至上观念与复仇母题”等五种文化母题之下进行审视，是《家族文化与20世纪中国家族文学的母题形态》对百年中国家族文学精神特征的精妙勾勒。     

School assessment in Thailand: roles and achievement of ONESQA

The 1999 National Education Act emphasizes the importance of quality assurance and national education standards. The main principle of educational provision of high standard lies in recognition of the importance of assessment for enhancing educational quality and raising the standard. Such recognition has led to establishment in Thailand of the Office for National Education Standards and Quality Assessment (ONESQA). The office is an independent body set up to develop the criteria, methods for external assessment and assessment of educational institutions at each level of education as stipulated in the national education law. The ONESQA became operational in November 2000 and it must appraise every school at least once every 5-year cycle. In this paper, the unique and the roles of the ONESQA will be described. The achievement of the ONESQA concerning the first round assessment of 35,134 schools at the basic education level will be reported and recommendations for quality improvements and lessons learned for the second round assessment will be explored.     

高等院校在科学教育中的功能与作用

高等院校具备生产新的科学知识和传播科学理念的功能;具有培养人的科学素养和将科技知识运用于实践并推动社会生产力发展的作用。努力发挥高校的这种功能与作用,有助于提高全体公民的科学素养,从而推动社会文明的进步。     

浅析精英文化的困境与重建--以20世纪90年代以来小说中知识分子形象为例

20世纪90年代以来,伴随着大众文化的日益兴起,多元文化格局下精英文化逐渐退居边缘,知识分子面临着外部市场经济大潮的冲击以及内部自我身份的认同危机。相应地,小说中塑造的知识分子形象被颠覆,传统理想主义角色被消解。而小说中知识分子的形象的解构,加速了精英文化偏离正确的价值导向。这时候一部分作家以批判反思的创作心态,对知识分子形象进行重塑,给现实中的知识分子以警醒,同时为精英文化的重建提供了重要的启示。     

转型期我国公共政策制定的价值缺失与重塑

公共政策以公共利益为基本价值取向,其制定和执行应遵循公共、正义、公正等基本原则。在当前处于社会转型的矛盾凸显期,公共政策的制定存在主体性价值的缺失、过程的程序正义价值缺失及结果的公正性价值缺失等诸多价值问题。必须通过对主体性价值的再认识、政策制定的过程价值关注和政策价值导向与利益价值取向的辩证认识等措施来重塑公共政策的价值。     

The relative roles of IQ and cognitive processes in reading disability

The purpose of the present study was to explore the relative roles of IQ and cognitive processes in reading performance. A sample of 443 Spanish children (264 male, 179 female) ranging in age from 7 to 13 years were classified into four groups according to IQ scores (<80, 80–90, 90–110, >110) and reading disabled (RD) and normally achieving readers (NR) were compared. The findings indicate that IQ scores were not related to the differences between children with RD and NR. We found that reading‐related cognitive deficits do differentiate between RD and NR children. Therefore, IQ scores do not make a significant contribution to our understanding of reading disability.     

浅谈残疾人体育在现代社会中的功能和作用

体育锻炼,不仅使残疾人身体得到一定程度的康复,还能够使残疾人意志品质得到培养,获得身心的和谐发展,从而使人得到全面发展,实现人生梦想,成就人生价值,为社会文明发展做出贡献。探讨残疾人体育在现代社会中的功能和作用,对于推动残疾人融入社会,进而促进其全面发展有着重要的现实意义。     

浅析专业教师在思想政治工作中的作用

高校是教师开展思想政治工作的重要阵地。在高校思想政治工作体系中，专业教师由于始终处在教育第一线，其对学生开展思想政治工作，有着思想政治工作者所不能替代的一面。本文从有利于促进“教书”和“育人”有机结合的角度，强调在思想政治工作中应该进一步加强专业教师的作用，同时提出要全面建设一支高素质的专业教师队伍，以适应高等教育的发展，肩负起“促进人的全面发展”的历史重任。     

论现代远程教育中教师地位及作用的变化

现代远程教育利用电视、计算机、网络等教育技术，师生时空分离、学生自主学习，是一种全新教学形式，因而教师在教学中的地位与作用发生了巨大的变化：从中心、主导地位退居到从属、辅助地位，由主角变成配角，由台前转到了幕后，由教学变为助学，即主要表现为教学中的指导、辅导、督导作用。认识这一变化，对把握现代远程教学的特点和规律，提高远程教学与人才培养的质量，促进现代远程教育的健康发展，具有重要的意义。     

Rethinking the roles of mentor and mentee in the context of student suicide

Student suicides and attempted suicides are on the rise globally, and the numbers continue to climb steeply in most Westernized countries. School personnel remain untrained and uninformed in the area of suicide; few teachers or administrators can accurately identify the characteristics of suicidal behavior and fewer still have any knowledge of appropriate ways to deal with deeply troubled students. This article uses a powerful and tragic story of a student’s suicide as a catalyst for rethinking the structure and goals of mentoring relationships. A new approach, pairing novice teachers whose pre‐service education curriculum included specific training in recognizing and addressing the emotional needs of students with mentors experienced in real‐world classroom dynamics and the effects of school culture on children could improve the school experience for many students and potentially reduce the number of suicides or attempted suicides.     

网络传媒语境下少数民族文化的传播发展——以我国彝族年网络报道为例

网络传媒对少数民族文化的传播发展有巨大的重塑作用．通过对近几年我国彝族年的网络报道追踪调查,发现我国少数民族的传统文化在网铬传媒的“显微镜”下逐渐发生着蜕变,这其中既有“因网络”而“变文化”的被动文化重塑,也有“因文化变”而“显于网络”的文化诉求．网络传播的“交互性”、“开放性”与“文化资源重新配置”等特性,为各种少数民族文化资源提供了更为广泛的展示空间,成为各类文化的“自我抒写者”书写个人见解的新式平台,同时,增进了各种文化之间的交流．网络传媒对少数民族文化的发展既是挑战又是机遇：一方面,网络传媒可以帮助更广泛受众更深刻地理解、传播与保护少数民族文化;另一方面,在网络传播的过程中,某些少数民族文化之精髓无形中被消解殆尽,最后成为“象征的符号文化”．     

网络文化背景下高校思想政治理论课教师的角色重塑

高校思想政治理论教育要取得实效必须顺应时代发展,当社会的文化背景从非网络文化转向网络文化时,高校教师必须改变传统的做派,进行角色重塑,以期切合学生的实际精神需求。     

高校体育教学培养学生创新能力的研究

在阐明创新能力的内涵、培养与发展创新能力的条件的基础上，提出了在高校体育教学中培养学生创新能力的方法．