桔皮果胶降脂和抗凝的实验观察

普通饲料加入15％果胶连续饲养10d,能显著降低正常小鼠血清总胆固醇.用10％果胶分别拌入普通饲料与高脂饲料中喂养大鼠,结果不仅能使普通饲饵的大鼠血清TC、TG及TC/HDL-ch的比值显著下降,而且能降低高脂血大鼠的血脂,减少肝组织内的脂质沉积,同时还有降低高脂模型大鼠血浆粘度比,抑制血小板聚集的作用。     

Study of Serum Homocysteine, Folic Acid and Vitamin B12 in Patients with Preeclampsia

The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B(12) in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B(12) over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B(12) were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B(12) concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B(12) levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B(12) along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia.     

冠心病患者血浆同型半胱氨酸变化及叶酸的干预治疗

目的 了解血浆同型半胱氨酸(Homocysteine，Hcy)、叶酸和维生素(Vit)B12水平与冠心病的关系；观察叶酸干预治疗高Hcy血症的疗效．方法 经冠脉造影确诊的冠心病患者97例、亚冠心病患者58例及完全正常3l例，用高效液相色谱法测血浆Hcy水平，用放免法测血浆叶酸和VitB12浓度．其中高Hcy血症病人每天服用叶酸5mg，观察4周和8周后血浆Hcy水平变化．结果 冠心病和亚冠心病患者血浆Hcy水平明显高于正常人，叶酸和VitB12水平则明显下降；冠心病患者冠脉病变支数越多，血浆Hcy升高和叶酸、VitB12下降越明显；叶酸治疗高Hcy血症患者4周和8周，分别使血浆Hcy水平下降12．5％和38．5％．结论 冠心病和亚冠心病患者血浆Hcy水平明显升高，高Hcy血症是冠心病的危险因素之一．血浆Hcy水平变化与冠脉病变程度正相关．叶酸干预治疗可使高Hcy血症患者血浆Hcy浓度明显降低．     

Study on Impact of Iron and Folic Acid on the Plasma Trace Minerals in Pregnant Anemic Women

Iron deficiency anemia is one of the causes that lead to significant mortality and morbidity among pregnant women and fetus. The present study was undertaken to explore oral iron supplementation can modify the metal contents in pregnant anemic women. Iron and folic acid supplementations was given to 500 anemic women (mild = 200, moderate = 200, and severe = 100) and 100 age matched non-anemic controls daily for 100 days. Blood index values and plasma trace minerals were estimated as per standard protocols. Haemoglobin and ferritin levels were found significantly increased (p < 0.001) in anemic and control subjects after treatment. Moreover, the serum transferring receptor levels and total iron binding capacity were found significantly decreased in all treated groups. Iron (Fe), zinc (Zn) and copper (Cu) levels were found increased (p < 0.01) after oral iron supplementation groups. Moreover, selenium (Se) manganese (Mn) and were found to be decreased in all treated groups. Data provides the conclusion that iron and folic acid supplementation recovered the essential trace minerals, except manganese, which may lead to various complications including peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus.     

评价型指标标准化与评价方法对学术评价影响研究——以TOPSIS评价方法为例

所谓标准化方法的评价功能就是根据标准化得分直接进行优劣判断,评价方法的评价功能就是根据评价值的大小直接进行优劣判断,这两个问题是学术评价的基础方法论问题,长期没有得到重视,并且被排序分析所掩盖。文章以TOPSIS方法为例,认为sigmoid标准化具有评价功能,并以JCR2017无机与核化学期刊为例进行了实证研究。研究结果表明:评价值的评价功能受指标标准化方法与评价方法的影响;sigmoid标准化方法具有评价功能;现有的极大值标准化、极差标准化、功效系数法标准化方法均不具备评价功能;TOPSIS评价方法具有评价功能;sigmoid标准化改变了指标的统计特征;sigmoid标准化TOPSIS评价结果与极大值标准化有所差异;sigmoid标准化TOPSIS评价改变了评价值的统计特征;标准化与评价方法的评价功能对学术评价冲击较大。     

高校专利研发中“鲁日观念”表征及问题研究

国家近期密集发布系列文件推动协同创新,引导解决科研资源配置分散、封闭、低效等问题.以江苏南京高校专利研发为分析案例样本,对近30年来高校专利研发中协同创新工作提供一种“表征水平、呈现问题”的方法,呈现高校专利研发中“鲁日观念”存在程度,探讨与其相关的协同创新问题、改进策略,以利于我国高校专利研发切实从“鲁日时代”走向“协同创新时代”.     

技术能力评价：理论与方法

概述了技术能力评价研究的最新进展。技术能力评价研究从局限于企业自身的技术资产，到相应的技术组织和管理，再到外部的技术知识连接，极大地丰富了对技术能力内涵的认识。技术评价的期权方法的引入，进一步揭示了技术资产多方面的价值，加强了企业应对未来技术竞争的能力。     

Apocynaceae系细胞尿苷二磷酸葡萄糖焦磷酸化酶的纯化和表征

经 4步分离纯化的Apocynaceae植物培养细胞尿苷二磷酸葡萄糖焦磷酸化酶(UGPase)的比活为 2 0 4 9U mg ,与细胞粗提液相比 ,活力提高 97倍 ,活力回收率为 2 1 %,可直接用于尿苷二磷酸葡萄糖 (UDPG)的合成 ,并且储存稳定性很好 .UGPase的最适pH值为 7 2 ,UGPase的最适温度为 37℃左右 .Mg2 是UGPase发挥活力所必需的 .高浓度UTP和Glc 6 P均能抑制UGPase的活力     

就业质量评价——高校就业状况评价新方式

一直以来,政府、高校侧重于把＂就业率＂作为评价高校毕业生就业状况的重要指标,用＂就业率＂代替了＂就业质量＂。只有把＂就业质量＂作为评价毕业生就业状况的标尺,才能真正全面地反映毕业生就业的真实状况,从根本上解决就业问题,促进社会、国家、企业及个人的发展。     

并购能力:概念、构成要素与评价

结合并购本质和企业能力分析,提出了并购能力的概念;并从支付能力、信息能力、组织能力和整合管理能力四方面阐述了并购能力的构成,构建了并购能力评价指标体系;建立了基于模糊积分的并购能力评价模型。以A企业为例对其并购能力状况进行实证分析,论证了该评价方法的科学性和可行性。     

数字资源:规划、评价与选择

随着数字图书馆的发展,数字资源在图书馆的馆藏建设中占据着越来越重要的地位,如何规划与选择数字资源已成为图书馆馆藏建设的重要课题。本文从高校研究型图书馆的角度出发,结合实践经验,就如何规划、评价与选择数字资源提出了几点看法。     

社区信息化评价：模型构建及分析——以安徽省合肥市为例

文章构建了社区信息化系统用户满意度概念模型,并以安徽省舍肥市300户居户为样本对模型进行验证性研究。结果表明：所有观测变量均较好地解释上层结构变量;公众预期对电子公共服务系统的差异感知和满意度是否适配没有显著影响,差异感知对公众满意度没有显著影响;电子公共服务质量感知的维度划分与差异感知观测变量的设置都是合理的;电子公共服务公众满意度对政府形象的影响显著。     

关于进一步加强报刊管理的意见

概括介绍了国外学者近十年来有关期刊质量评价的研究工作，重点介绍了国际上学者们对影响因子在期刊评价中的作用所持的不同观点，概述了影响因子的不同计算方法以及影响因子在科研评价中的作用。     

Hb Hope: A Rare Variant of Haemoglobin-Forged a Rise in HbA1c on Immunoturbidimetric Assay

Glycosylated hemoglobin (HbA1c) determination is a powerful means for assessing the evaluation and management of patients with diabetes mellitus. Hemoglobin (Hb) variants and chemically modified derivatives of Hb can affect the accuracy of measurement of HbA1c done by various analytical methods. We report a patient with a rare variant of Hb (Hb Hope) that caused an abnormally high value of HBA1c when assayed using immunoturbidimetric assay (“Tina-quant” 2nd generation assay) and also elucidate the nature of the variant.     

An overview of online fake news: Characterization,detection, and discussion

Over the recent years, the growth of online social media has greatly facilitated the way people communicate with each other. Users of online social media share information, connect with other people and stay informed about trending events. However, much recent information appearing on social media is dubious and, in some cases, intended to mislead. Such content is often called fake news. Large amounts of online fake news has the potential to cause serious problems in society. Many point to the 2016 U.S. presidential election campaign as having been influenced by fake news. Subsequent to this election, the term has entered the mainstream vernacular. Moreover it has drawn the attention of industry and academia, seeking to understand its origins, distribution and effects.Of critical interest is the ability to detect when online content is untrue and intended to mislead. This is technically challenging for several reasons. Using social media tools, content is easily generated and quickly spread, leading to a large volume of content to analyse. Online information is very diverse, covering a large number of subjects, which contributes complexity to this task. The truth and intent of any statement often cannot be assessed by computers alone, so efforts must depend on collaboration between humans and technology. For instance, some content that is deemed by experts of being false and intended to mislead are available. While these sources are in limited supply, they can form a basis for such a shared effort.In this survey, we present a comprehensive overview of the finding to date relating to fake news. We characterize the negative impact of online fake news, and the state-of-the-art in detection methods. Many of these rely on identifying features of the users, content, and context that indicate misinformation. We also study existing datasets that have been used for classifying fake news. Finally, we propose promising research directions for online fake news analysis.     

晦暗语境与内涵刻画

所谓的晦暗语境是指那些使得经典逻辑中与外延相关的同一替换定律失效的语言现象。由于这一语言现象的出现被归因于经典逻辑的外延性原则,因此由蒙太古、卡尔纳普等学者所创立的内涵逻辑才被应用到对晦暗语境的解释中来,以刻画表达式的内涵。而文章将在蒙太古内涵逻辑及其新近发展的基础上说明该理论在解释晦暗语境问题上的局限性并尝试利用性质基始论对现有的理论做一个改进和修正,即不再将个体看成处理内涵问题时不可再分的基始对象,而是要进一步分析个体的性质以说明晦暗语境的出现机理以及解释方式。     

高效液相色谱法检测细胞能量代谢物质的方法建立与应用

建立高效液相色谱法(HPLC)测定细胞中ATP、ADP和AMP含量的方法,以比较高糖培养的MRC-5细胞和D-半乳糖诱导的拟衰老MRC-5细胞能量代谢水平。体外培养的细胞经高氯酸裂解后,用反向HPLC法检测两组细胞ATP、ADP和AMP的含量。HPLC系统采用Ecosil C18反相柱(4.6*250mm 5μm pH 2～8),流动相为15mM磷酸二氢钾缓冲液和10%甲醇,流速0.5mL/min,紫外检测波长为254nm;检测温度为25℃,进样量20μL。以标准曲线法计算ATP、ADP和AMP含量,并计算腺苷酸能荷(EC)。结果显示拟衰老细胞的ATP含量及EC较对照组显著降低,而AMP含量明显升高,差异具有统计学意义(p<0.05),但两组之间的ADP含量没有明显差别。结果表明高效液相色谱法可检测出不同状态细胞能量物质的差异,其具有操作简便、快速、重现性好等特点,可以作为线粒体能量代谢功能的评估方法之一。     

云南省全社会科技投入现状分析与评价

对2001年云南省全社会研究与试验发展活动的科技投入现状、特点进行了深入的分析与评价，将云南与有关省市区研究与试验发展活动的科技投入进行评价，提出了增加科技投入的对策建议。