Transcription through chromatin — Link to diseases and therapeutics

The expression of chromosomal genes is regulated by posttranslational modification of both histone and nonhistone chromatin proteins and ATP-dependent remodeling of chromatin. Dysfunction of the modification and remodeling machineries can lead to several diseases, which include cancer, cardiac hypertrophy, and asthma. Many genetic diseases can also lead to malfunction of the machinery. The enzymes responsible for chromatin organization are the new targets for therapeutics. Inhibitors and activators of histone acetyltransferases and inhibitors of histone deacetylases may serve as new generation drugs.     

An Analysis of the Three Translated Versions of Youth——From the Perspective of Dynamic Equivalence

<正>1.Analysis of the Three Translated Versions of Youth1.1 General knowledge on Youth and its three translated versions.Samuel Ullman,the author of Youth,was born in Germany in 1840,and for years,he and his prose poem Youth have been renowned and admired in the world.Youth has over ten versions.On account of the vigorous practices of translation,it is quite worthwhile to make a further study.1.2 Equivalence at different levels.The following analysis of the three translated versions will show us a vivid explanation applying the principle of dynamic equivalence in the aspects of le     

Dynamic track-soil interaction——calculations and measurements of slab and ballast tracks

The dynamic behaviour of slab and ballast tracks was investigated using measurements and calculations. Hammer impacts and train passages were analysed and measurements were made using geophones(velocity transducers) which had been time-integrated to displacements. The calculations were carried out in the frequency-wavenumber domain for multi-beamon-continuous soil models. The characteristics of the different tracks and track elements were established in theory and by experiment. The frequency-dependent compliances(displacement transfer functions) showed clear rail-on-railpad resonances or highly damped track-soil resonances. Compared to the rail and sleeper, the track slab had much lower amplitudes. The slab track usually had the highest rail amplitudes due to soft railpads. Train passage yielded track displacements which were a superposition of the axle loads from the two neighbouring axles of a bogie and from the two bogies of two neighbouring carriages. This global behaviour was characteristic of the track slab of the slab track, whereas the rails of the slab and the ballast tracks behaved more locally with only one bogie of influence. The measurements agreed very well with the theory of continuous soil in the case of the six measured slab tracks and acceptably well for the six measured ballast tracks. The measurements allowed us to find appropriate model parameters and to check the models. For example, the Winkler model of the soil was found to be less appropriate because it reacted more locally.     

On Translation of Images in English Poems——in Virtue of the Dynamic Equivalence Theory

Image is not only an essential part,but also a major means to convey the implications in English poems.It is a literal and concrete representation of a sensory experience of an object.The rendering of images in English poems into Chinese can be guided by the dynamic equivalent translation theory put forward by Dr.Eugene A Nida.The theory emphasizes the roughly equivalent response of the target language receptors to the TL text to that of the source language receptors to the SL text.To achieve a Dynamic Equivalence,methods like Direct Translation,Addition,and Substitution can be employed in the translation of images in English poems.     

Zooming in Time—Exploring Students’ Interpretations of a Dynamic Tree of Life

Journal of Science Education and Technology - Central to evolution is the concept of a common ancestry from which all life has emerged over immense time scales, but learning and teaching temporal...     

Dynamic properties of composite cemented clay

INTRODUCTIONSoftsoilsarewidelydistributedinChinasco-astalareas.The1985earthquakethatinflictedgreatdamagetoMexicoCitysitedonsoftsoilfounda-tionsgreatlyattractedattentionofresearchersandengineersandmovedthemtostudythedynamicpropertiesofsoftsoils.Manyresearcheshavebeendedicatedtothestudyofdynamicpropertiesofsoftsoils.InChina,deepcementmixingmethodshavebeenwidelyusedinthecoastalareas.Theme-chanicalpropertiesofthesecompositefoundationsoilsarenotthesameasthatofundisturbedsoftsoilsorotherkinds…     

The Broken of the American Dream——looking through The Great Gatsby

F.Scott Fitzgerald is one of the greatest American writers of the 1920s.his masterpiece The Great Gatsby just holds up a mirror to the social conviction and meditation on American history.In this novel,we could see Gatsby’s disillusionment and the end of the American dream.     

Evaluating writing instruction through an investigation of students’ experiences of learning through writing

Learning through writing is a way of learning not only the appropriate written expression of disciplinary knowledge, but also the knowledge itself through reflection and revision. This study investigates the quality of a writing experience provided to university students in a first-year biology subject. The writing instruction methodology used is Genre-based literacy pedagogy, designed to help both with learning disciplinary knowledge and its appropriate written presentation. Evaluative research methodologies from Student Learning Research are used and include the use of three closed-ended questionnaires and an open-ended questionnaire. The results of the research suggest ways of improving the writing instruction by better understanding the previous writing experiences of the students, improving the instructional materials, clarifying goals of the writing tasks at key stages in the writing process, and helping students to improve their approach to the writing experience.in final form: 23 August 2004     

Research on the Dynamic Performance of Polyacrylonitrile Muscles

The dynamic property of polyacrylonitrile (PAN) muscles was tested.The test results can help us to master PAN muscles‘ mechanical and chemical behaviors,which are indispensable for us to build dynamica model for the artifical muscle,Furthermore,here we provide an important experimental way to study gel muscles.     

Dynamic Behavior of a New Hydraulic Steel Gate

A new style of hydraulic steel gate based on the principle of bionics is proposed in this paper. It has a fish-like shape and consists of right arches, invert arches, connection components and a face plate. It would be first applied in the project of Caoe River Sluice, used as both tidal barrage and flood gate. Compared with conventional hydraulic steel gate of beam grids, this new style of hydraulic steel gate can save up to 30%-50% of steel consumption. The dynamic behavior of the new gate under the impact load of tidal bore is investigated. The impact load of tidal bore is considered by a load spectrum obtained by field observation over a long period of time. Then a numerical analysis of the gate under the load spectrum is carried out by finite element method. The fluid-structure interaction is considered in the analysis. And a comparison between the response of the gate under the impact load and the response of the gate under the corresponding static load is conducted and indicates that the gate has a dynamic magnification factor of 1.2.     

Dynamic performance analysis model of high-reliability EMS-Maglev system

In this paper, a modified transient finite element (FE) algorithm for the performance analysis of magnetically levitated vehicles of electromagnetic type is presented. The algorithm incorporates the external power system and vehicle’s movement equations into FE model of transient magnetic field computation directly. Sliding interface between stationary and moving region is used during the transient analysis. The periodic boundaries are implemented in an easy way to reduce the computation scale. It is proved that this method can be used for both electro-motional static and dynamic cases. The test of a transformer and an EMS-Maglev system reveals that the method generates reasonable results at very low computational costs comparing with the transient FE analysis.     

Dynamic Analysis of Structural Columns Subjected to Impulsive Loading

For a building structure subjected to impulsive loading, particularly shock and impact loading , the response of the critical columns is crucial to the behaviour of the entire system during and after the blast loading phase. Therefore, an appropriate evaluation of the column response and damage under short-duration impulsive loading is important in a comprehensive assessment of the performance of a building system. This paper reports a dynamic analysis approach for the response of RC columns subjected to impulsive loading. Considering that the dynamic response of a column in a frame structure can also be affected by the floor movement which relates to the global vibration of the frame system, a generic column-mass model is used, in which a concentrated mass is attached to the column top to simulate the effect of a global vibration. To take into account the high shear effect under impulsive load, the model is formulated using Timoshenko beam theory, and three main nonlinear mechanisms are considered. Two typical scenarios, one under a direct air blast loading, and another under a blast-induced ground excitation, are analyzed and the primary response features are highlighted.     

Dynamic Analysis of Structural Columns Subjected to Impulsive Loading

For a building structure subjected to impulsive loading, particularly shock and impact loading, the response of the critical columns is crucial to the behaviour of the entire system during and after the blast loading phase. Therefore, an appropriate evaluation of the column response and damage under short-duration impulsive loading is important in a comprehensive assessment of the performance of a building system. This paper reports a dynamic analysis approach for the response of RC columns subjected to impulsive loading. Considering that the dynamic response of a column in a frame structure can also be affected by the floor movement which relates to the global vibration of the frame system, a generic column-mass model is used, in which a concentrated mass is attached to the column top to simulate the effect of a global vibration. To take into account the high shear effect under impulsive load, the model is formulated using Timoshenko beam theory, and three main nonlinear mechanisms are considered. Two typical scenarios, one under a direct air blast loading, and another under a blast-induced ground excitation, are analyzed and the primary response features are highlighted.     

Paralel Computation of the Noncooperative Equilibria for Dynamic Games

ＰａｒａｌｅｌＣｏｍｐｕｔａｔｉｏｎｏｆｔｈｅＮｏｎｃｏｏｐｅｒａｔｉｖｅＥｑｕｉｌｉｂｒｉａｆｏｒＤｙｎａｍｉｃＧａｍｅｓＬｕＺｉｆａｎｇ（卢子芳）ＤａＱｉｎｇｌｉ（达庆利）ＸｕＮａｎｒｏｎｇ（徐南荣）（ＳｃｈｏｏｌｏｆＥｃｏｎｏｍｉｃｓａｎｄＭａ...     

Reconstructing Prior Beliefs through Teacher Education Programs——Review of Research into Changes in Language Teacher Beliefs

This review of research into changes in language teacher beliefs reveals that carefully designed language teacher education courses are effective in reconstructing teachers’prior beliefs. When teaching practices are added to the teacher education programs, when adjustments are made to the structure of teacher education courses, and when research practices are incorporated in teacher education programs, significant changes are seen in teachers’beliefs.     

Simple Analysis of War Scars left to Hemingway——through comparative study of Henry''s and Hemingway''s experiences and sufferings in the war

The First World War and the Second Wodd War brought Hemingway tremendous seam both physically and mentally, which became his nightmares in his later life. To better understand Hemingway's war scars and the masons, this article mainly analyses Henry's (Henry, the hero of A Farewell to Arms) and Hemingway's experiences and suffer-ings in the war respectively, and then makes a detailed comparative study. Another purpose of studying this topic is to help people realize that there should be no wars for mankind and that the whole world needs peace!     

Static and Dynamic Analyses of Long-Span Spatial Steel-Cable-Membrane Hybrid Structures

Withthedevelopmentofeconomyandtherequire mentofmunicipalconstruction ,long spanspatialstruc turesariseinthecitiesrapidly .Furthermore ,thespansofstructuresbecomelongerandlonger ,andthestruc turalsystemsbecomemoreandmorecomplex .Atthesametime,somecomplicatedcompositeorhybridstruc tures ,suchastensegritystructure[1,2 ] ,cable membranestructure[3,4 ] ,openablestructure[5] ,stringstructure[5] ,andinflatablestructure[4 ] etc .,appearsuccessivelybyus ingthematerialsofsteel,cableandmembranesyntheti c…     

Shape Optimal Design of Hydrodynamic Bearing Based on Dynamic Characteristics

ＳｈａｐｅＯｐｔｉｍａｌＤｅｓｉｇｎｏｆＨｙｄｒｏｄｙｎａｍｉｃＢｅａｒｉｎｇＢａｓｅｄｏｎＤｙｎａｍｉｃＣｈａｒａｃｔｅｒｉｓｔｉｃｓＣｈｅｎＹｕｎｆｅｉ（陈云飞）ＱｉａｎＲｕｉｍｉｎｇ（钱瑞明）（ＤｅｐａｒｔｍｅｎｔｏｆＭｅｃｈａｎｉｃａｌＥｎｇ...     

Dynamic Graphical Simulation of a Large Scale Motor Crane Chassis

ＤｙｎａｍｉｃＧｒａｐｈｉｃａｌＳｉｍｕｌａｔｉｏｎｏｆａＬａｒｇｅＳｃａｌｅＭｏｔｏｒＣｒａｎｅＣｈａｓｓｉｓＣｈｅｎＹｕｎｆｅｉａ（陈云飞）ＨｕａｎｇＸｉｓｈｉｂ（黄锡时）ＸｕＳｈａｎｇｘｉａｎａ（许尚贤）（ａＤｅｐａｒｔｍｅｎｔｏｆＭｅｃｈａｎ...     

Simulation And Optimization of Electric Vehicle＇s Dynamic Performance

利用基于MATLAB/Simulink的电动汽车仿真软件建立整车的动力性能仿真模型,根据建立的模型对电动汽车的动力性能进行了分析.使用ADVISOR软件中的Autosize部分对主要的参数进行了优化,缩短了开发周期,降低了设计成本.