A型肉毒毒素注射配合Vojta训练治疗痉挛型脑瘫患儿46例的临床观察

目的观察A型肉毒毒素(BTX-A)注射配合Vojta训练对痉挛型脑瘫患儿的治疗效果,并探讨对其运动功能及日常生活活动能力(ADL)的影响。方法将46例双下肢痉挛型脑瘫儿童随机分为观察组(采用BTX-A位点注射结合Vojta训练)和对照组(仅采用Vojta训练治疗)。观察两组患儿的双下肢痉挛与ADL改善情况。结果经过4个月和8个月治疗后分别比较,观察组患儿的双下肢痉挛、ADL改善情况明显优于对照组(P<0.01)。结论 BTX-A注射结合Vojta训练能显著提高患儿的运动功能和生活活动能力,是一种极为有效的治疗脑瘫患儿肢体痉挛的方法。     

咬肌单侧注射A型肉毒毒素对大鼠下颌骨生长发育的影响

通过诱导肌肉功能衰退,评估 A 型肉毒毒素（BTX-A）对下颌骨生长发育的影响。     

肉毒杆菌及其毒素概述

本文对肉毒杆菌毒素的致病机理、儿童感染中毒的临床表现以及肉毒杆菌的美容价值进行了分析。     

婴幼儿不宜吃蜂蜜

蜂蜜(尤其是陈年蜂蜜)中含有肉毒杆菌。由于婴幼儿胃肠道分泌胃酸的功能尚未健全,使肉毒杆菌很容易在肠道中生长、繁殖,产生毒素,出现婴幼儿肉毒病。发病时首先出现顽固性便秘,继而出现     

形形色色的剧毒生物

希拉毒蜥：希拉毒蜥是世界上仅存的两种濒临灭绝的毒蜥蜴的一种。它的下颌十分有力,长有可怕的毒牙。当它咬到猎物时,毒液会从伤口进入猎物体内,由体内的淋巴腺带到身体的其他部位。一旦毒液到达心脏,毒素就会迅速进入猎物的血液。这种毒素攻击的不是血液而是血管壁。     

6-12 Months 远离肉毒杆菌

肉毒杆菌?与肉有关吗?不用紧张,让我们一起来认识一下这个来自于土壤和灰尘中的细菌! 与肉无关的“肉毒杆菌”中毒肉毒杆菌主要栖息于土壤和灰尘中,而肉毒杆菌中毒是一种罕见的,而且比较严重的,通过食物传播的疾病。它主要是因为摄取被土壤中的肉毒杆菌污染的食物而引起的。肉毒杆菌中毒有3种不同的类型:食物携带型中毒、创伤型中毒和婴儿肉毒杆菌中毒。后者最为普遍,据美国疾控中心数     

读书使人优美

优美在词典上的意思是:美好。做一个美好的人,我相信是绝大多数人的心愿。谁不愿意美好啊?除了心灵的美好,外表也需要美好。为了这份美好,人们使出了万千手段。比如刀兵相见的整容,比如涂脂抹粉的化妆。为了抚平脸上的皱纹,竟然发明了用肉毒杆菌的毒素在眉眼间注射,让面部微小神经麻痹,换来皮肤的暂时平滑……     

读书使人优美

优美在字典上的意思是：美好。 做一个美好的人,我相信是绝大多数人的心愿。除了心灵的美好,外表也需美好。为了这份美好,人们使出了万千手段。比如刀兵相见的整容,比如涂脂抹粉的化妆。为了抚平脸上的皱纹,竞然发明了用肉毒杆菌的毒素在眉眼间注射……让我这个曾经当过医生的人,胆战心惊。     

经肛门Ⅰ期结肠拖出术治疗先天性巨结肠

目的:介绍经肛门Ⅰ期结肠拖出术治疗先天性巨结肠的经验.方法:10例先天性巨结肠均经肛门Ⅰ期结肠拖出术治疗,方法为在直肠齿状线上0.5cm处游离直肠粘膜达腹膜返折后切断肌鞘1周,后壁肌鞘"∨"形切除,游离拖出近端正常结肠与肛缘二层吻合.结果:10例经肛门Ⅰ期结肠拖出术根治的患儿,手术时间短,出血少,术后反应轻,无术中和术后并发症.结论:经肛门Ⅰ期结肠拖出术适宜治疗3岁以内的短段型、普通型先天性巨结肠,较经腹切口巨结肠根治术简单、安全,且达到同样效果.     

读书使人优美

优美在字典上的意思是：美好。 做一个美好的人,我相信是绝大多数人的心愿。谁不愿意美好啊？除了心灵的美好,外表也需美好。为了这份美好,人们使出了万千手段。比如刀兵相见的整容,比如涂脂扶粉的化妆。为了抚平脸上的皱纹,竟然发明了用肉毒杆菌的毒素在眉眼间注射,让面部微小神经麻痹,换来皮肤的暂时平滑……     

Influence of injection of Chinese botulinum toxin type A on the histomorphology and myosin heavy chain composition of rat gastrocnemius muscles

Background and objective

Botulinum toxin type A (BoNT/A) is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa (SNAP-25). It has gained widespread use as a treatment for cerebral palsy and skeletal muscle hypertrophy. In China, Chinese botulinum toxin type A (CBTX-A), a type of BoNT/A, is in widespread clinical use. However, the changes in the morphological and biochemical properties of treated muscles and in remote muscles from the CBTX-A injection site are relatively unknown. Therefore, we investigated the changes in histomorphology and myosin heavy chain (MyHC) isoform composition and distribution in rat gastrocnemius muscles after intramuscular injection of CBTX-A.

Methods

The weakness of the injected muscles was assessed periodically to identify their functional deficiency. Muscle slices were stained with hematoxylin-eosin (HE) and adenosine triphosphatase (ATPase). MyHC isoform composition was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to uncover changes in morphological and biochemical properties.

Results

Our findings demonstrate that following injection of CBTX-A 5 U into rat gastrocnemius muscles, shifts in MyHC isoform composition emerged on the third day after injection and peaked in the fourth week. The composition remained distinctly different from that of the control group after the twelfth week. More specifically, there was a decrease in the proportion of the type IIb isoform and an increase in the proportions of type IIx, type IIa, and type I isoforms.

Conclusions

Data revealed that CBTX-A led to a shift in MyHC composition towards slower isoforms and that the MyHC composition remained far from normal six months after a single injection. However, no noticeable remote muscle weakness was induced.     

黄沙岭隧道渗水处理

黄沙岭隧道在掘进过程中,三次穿越G318国道上方的水沟,岩体破碎,地下水属基岩裂隙水,涌水量较大,致使掌子面一度停止施工,给施工带来极大的安全隐患。通过对涌水状况分析,采取了对掌子面裂隙水进行封堵、引排,将Ⅳ型衬砌变更为Vb型衬砌,在拱部施作超前周壁预注浆,结合隧道围岩裂隙局部注浆、全断面帷幕注浆等措施,从而顺利地完成涌水段施工。     

76例片状增生性瘢痕切除并刃厚皮片移植或瘢痕上皮回植术对比研究

目的:探讨片状增生性瘢痕外科手术治疗的方法及疗效。方法:对76例片状增生性瘢痕采用随机分组进行增生性瘢痕切除并刃厚皮片移植术;增生性瘢痕切除、瘢痕上皮回植术两种手术方法比较性研究。结果:两种方法在疗效上无显著差异(P>0.05),但手术野数目和住院时间存在显著差异(P<0.05)。结论:片状增生性瘢痕可以采用瘢痕切除、刃厚皮片移植或瘢痕上皮回植术治疗,瘢痕上皮回植术优于刃厚皮片移植术。     

立井破坏与疏水沉降之间内在关系的研究现状

立井井壁破坏是一种特殊类型的工程地质灾害,是人类采矿活动和地质环境相互作用的结果。总结了立井井壁的受力变形规律,系统的介绍了国内外有关学者对该课题的研究成果。研究内容对立井井壁结构的优化设计、防破坏措施的研究具有重要的参考价值。     

克鼠星1号防治褐家鼠和小家鼠的研究

通过室内鼠罐饲养测定和现场灭鼠试验,对克鼠星1号在防治褐家鼠和小家鼠中的效果、适口性和安全性进行了研究。结果表明,克鼠星1号适口性好,褐家鼠和小家鼠的摄食系数高达0．76～1．02。克鼠星1号对褐家鼠和小家鼠的杀灭效果高,其中室内杀灭效果均为100．0％;野外试验为93．3％～97．9％。安全性测定显示,克鼠星1号亦是一种安全型灭鼠剂。鸡、猫和狗误食后15～30min即发生呕吐反应,无中毒或二次中毒现象发生。     

晋普山90202工作面落山角瓦斯治理探讨

我国绝大部分采煤工作面均采用"U"型通风方式,其落山角是采空区瓦斯的集中涌出区域。本文通过对综采工作面落山角瓦斯来源和瓦斯超限原因的分析,探索出一套"两进两回"治理落山角瓦斯的通风方式。该方式能有效提高局部积聚区域内瓦斯扩散强度,并能加强巷道中风流的瓦斯运移,治理落山角瓦斯简单易行、稳定可靠,有较好的推广应用价值。     

Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment

Metastasis is one of the main reasons causing death in cancer patients. It was reported that chemotherapy might induce metastasis. In order to uncover the mechanism of chemotherapy-induced metastasis and find solutions to inhibit treatment-induced metastasis, the relationship between epithelial-mesenchymal transition (EMT) and doxorubicin (DOX) treatment was investigated and a redox-sensitive small interfering RNA (siRNA) delivery system was designed. DOX-related reactive oxygen species (ROS) were found to be responsible for the invasiveness of tumor cells in vitro, causing enhanced EMT and cytoskeleton reconstruction regulated by Ras-related C3 botulinum toxin substrate 1 (RAC1). In order to decrease RAC1, a redox-sensitive glycolipid drug delivery system (chitosan-ss-stearylamine conjugate (CSO-ss-SA)) was designed to carry siRNA, forming a gene delivery system (CSO-ss-SA/siRNA) down-regulating RAC1. CSO-ss-SA/siRNA exhibited an enhanced redox sensitivity compared to nonresponsive complexes in 10 mmol/L glutathione (GSH) and showed a significant safety. CSO-ss-SA/siRNA could effectively transmit siRNA into tumor cells, reducing the expression of RAC1 protein by 38.2% and decreasing the number of tumor-induced invasion cells by 42.5%. When combined with DOX, CSO-ss-SA/siRNA remarkably inhibited the chemotherapy-induced EMT in vivo and enhanced therapeutic efficiency. The present study indicates that RAC1 protein is a key regulator of chemotherapy-induced EMT and CSO-ss-SA/siRNA silencing RAC1 could efficiently decrease the tumor metastasis risk after chemotherapy.

     

余甘子含片营养成分及其保健功能

由余甘子提取液制备得到余甘子含片置于微波消解仪中进行水解,然后利用高效液相色谱仪(HPLC)、等离子发射光谱仪(ICP)和氨基酸自动分析仪等分析样品中的营养成份,并探讨其保健功能.结果表明,余甘子含片中富含维生素、16种氨基酸和人体所必需的多种微量元素.在生津止咳、降脂减肥、降火解毒、抗癌和抗心血管疾病等方面具有积极的作用.     

Facing our Heuristic Limits: Expanding the Terminology for Types of Positive Face

This article adds to Lim and Bowers’ (1991) framework featuring two types of positive face: competence and fellowship face. We propose the addition of three types of positive face: character, social, and status face. We differentiate between each new type of face by examining: (a) protective strategies adopted, (b) types of face threats, (c) corrective strategies, and (d) pejorative labels threatening/attacking each type of face. The heuristic value for the positive face terms proposed is also explored through re-visiting a scholarly article in which positive face is analyzed. Data presented in that article are examined through the lens of the three proposed positive face terms. Finally, broader implications of theorizing are discussed, particularly with respect to politeness.     

高血压治疗的现状与展望

高血压病是全球范围内最常见的心血管系统疾病，是严重危害人们健康的疾病之一、目前高血压治疗仍然沿用传统的治疗方法，然而随着对高血压病发病机制研究的深入和各种新的抗高血压药物的研制和问世，对高血压的治疗思路和方法提出了新的挑战，故现阶段提出了在高血压个体化治疗的基础上同时从确切降压、稳定血压和阻断肾素-血管紧张素系统三方面进行治疗的新概念、从这三方面具体阐述了高血压新的治疗思路和方法．