On the Estimation of Nonlinear Mixed-Effects Models and Latent Curve Models for Longitudinal Data

Nonlinear models are effective tools for the analysis of longitudinal data. These models provide a flexible means for describing data that follow complex forms of change. Exponential and logistic functions that include a parameter to represent an asymptote, for instance, are useful for describing responses that tend to level off with time. There are forms of nonlinear latent curve models and nonlinear mixed-effects model that are equivalent, and so given the same set of data, growth function, distributional assumptions, and method of estimation, the 2 models yield equivalent results. There are also forms that are strikingly different and can yield different interpretations for a given set of data. This article discusses cases in which nonlinear mixed-effects models and nonlinear latent curve models are equivalent and those in which they are different and clarifies the estimation needs of the different models. Examples based on empirical data help to illustrate these points.     

Automated Latent Growth Curve Model Fitting: A Segmentation and Knot Selection Approach

Latent growth curve models are widely used in the social and behavioral sciences to study complex developmental patterns of change over time. The trajectories of these developmental patterns frequently exhibit distinct segments in the studied variables. Latent growth models with piecewise functions for repeated measurements of variables have become increasingly popular for modeling such developmental trajectories. A major problem with using piecewise models is determining the precise location of the point where the change in the process has occurred and uncovering the related number of segments. The purpose of this paper is to introduce an optimization procedure that can be used to determine both the segments and location of the knots in piecewise linear latent growth models. The procedure is illustrated using empirical data in order to detect the number of segments and change points. The results demonstrate the capabilities of the procedure for fitting latent growth curve models.     

Detecting Unobserved Heterogeneity in Latent Growth Curve Models

Growth mixture models combine latent growth curve models and finite mixture models to examine the existence of latent classes that follow distinct developmental patterns. Analyses based on these models are becoming quite common in social and behavioral science research because of recent advances in computing, the availability of specialized statistical programs, and the ease of programming. In this article, we show how mixture models can be fit to examine the presence of multiple latent classes by algorithmically grouping or clustering individuals who follow the same estimated growth trajectory based on an evaluation of individual case residuals. The approach is illustrated using empirical longitudinal data along with an easy to use computerized implementation.     

Application of Latent Growth Curve Analysis With Categorical Responses in Social Behavioral Research

Latent growth modeling allows social behavioral researchers to investigate within-person change and between-person differences in within-person change. Typically, conventional latent growth curve models are applied to continuous variables, where the residuals are assumed to be normally distributed, whereas categorical variables (i.e., binary and ordinal variables), which do not hold to normal distribution assumptions, have rarely been used. This article describes the latent growth curve model with categorical variables, and illustrates applications using Mplus software that are applicable to social behavioral research. The illustrations use marital instability data from the Iowa Youth and Family Project. We close with recommendations for the specification and parameterization of growth models that use both logit and probit link functions.     

Latent Curve Models and Latent Change Score Models Estimated in R

When using multiple imputation in the analysis of incomplete data, a prominent guideline suggests that more than 10 imputed data values are seldom needed. This article calls into question the optimism of this guideline and illustrates that important quantities (e.g., p values, confidence interval half-widths, and estimated fractions of missing information) suffer from substantial imprecision with a small number of imputations. Substantively, a researcher can draw categorically different conclusions about null hypothesis rejection, estimation precision, and missing information in distinct multiple imputation runs for the same data and analysis with few imputations. This article explores the factors associated with this imprecision, demonstrates that precision improves by increasing the number of imputations, and provides practical guidelines for choosing a reasonable number of imputations to reduce imprecision for each of these quantities.     

First- Versus Second-Order Latent Growth Curve Models: Some Insights From Latent State-Trait Theory

First-order latent growth curve models (FGMs) estimate change based on a single observed variable and are widely used in longitudinal research. Despite significant advantages, second-order latent growth curve models (SGMs), which use multiple indicators, are rarely used in practice, and not all aspects of these models are widely understood. In this article, our goal is to contribute to a better understanding of theoretical and practical differences between FGMs and SGMs. We define the latent variables in FGMs and SGMs explicitly on the basis of latent state–trait (LST) theory and discuss insights that arise from this approach. We show that FGMs imply a strict trait-like conception of the construct under study, whereas SGMs allow for both trait and state components. Based on a simulation study and empirical applications to the Center for Epidemiological Studies Depression Scale (Radloff, 1977 Radloff, L. S. 1977. The CES–D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1: 385–401. [Crossref], [Web of Science ®] , [Google Scholar]) we illustrate that, as an important practical consequence, FGMs yield biased reliability estimates whenever constructs contain state components, whereas reliability estimates based on SGMs were found to be accurate. Implications of the state–trait distinction for the measurement of change via latent growth curve models are discussed.     

A Second-Order Conditionally Linear Mixed Effects Model With Observed and Latent Variable Covariates

A conditionally linear mixed effects model is an appropriate framework for investigating nonlinear change in a continuous latent variable that is repeatedly measured over time. The efficacy of the model is that it allows parameters that enter the specified nonlinear time-response function to be stochastic, whereas those parameters that enter in a nonlinear manner are common to all subjects. In this article we describe how a variant of the Michaelis–Menten (M–M) function can be fit within this modeling framework using Mplus 6.0. We demonstrate how observed and latent covariates can be incorporated to help explain individual differences in growth characteristics. Features of the model including an explication of key analytic decision points are illustrated using longitudinal reading data. To aid in making this class of models accessible, annotated Mplus code is provided.     

On the Correspondence between the Latent Growth Curve and Latent Change Score Models

There has been a great deal of work in the literature on the equivalence between the mixed-effects modeling and structural equation modeling (SEM) frameworks in specifying growth models (Willett &; Sayer, 1994). However, there has been little work on the correspondence between the latent growth curve model (LGM) and the latent change score model (see Grimm, Zhang, Hamagami, &; Mazzocco, 2013 Grimm, K. J., Zhang, Z., Hamagami, F., &; Mazzocco, M. M. (2013). Modeling nonlinear change via latent change and latent acceleration frameworks: Examining velocity and acceleration of growth trajectories. Multivariate Behavioral Research, 48, 117–143.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). We demonstrate that four popular variants of the latent change score model – the no change, constant change, proportional change, and dual change models – have LGM equivalents. We provide equations that allow the translation of parameters from one approach to the other and vice versa. We then illustrate this equivalence using mathematics achievement data from the National Longitudinal Survey of Youth.     

Fitting Structural Equation Model Trees and Latent Growth Curve Mixture Models in Longitudinal Designs: The Influence of Model Misspecification

When conducting longitudinal research, the investigation of between-individual differences in patterns of within-individual change can provide important insights. In this article, we use simulation methods to investigate the performance of a model-based exploratory data mining technique—structural equation model trees (SEM trees; Brandmaier, Oertzen, McArdle, & Lindenberger, 2013)—as a tool for detecting population heterogeneity. We use a latent-change score model as a data generation model and manipulate the precision of the information provided by a covariate about the true latent profile as well as other factors, including sample size, under the possible influences of model misspecifications. Simulation results show that, compared with latent growth curve mixture models, SEM trees might be very sensitive to model misspecification in estimating the number of classes. This can be attributed to the lower statistical power in identifying classes, resulting from smaller differences of parameters prescribed by the template model between classes.     

Using Design-Based Latent Growth Curve Modeling With Cluster-Level Predictor to Address Dependency

The authors compared the effects of using the true Multilevel Latent Growth Curve Model (MLGCM) with single-level regular and design-based Latent Growth Curve Models (LGCM) with or without the higher-level predictor on various criterion variables for multilevel longitudinal data. They found that random effect estimates were biased when the higher-level predictor was not included and that standard errors of the regression coefficients from the higher-level were underestimated when a regular LGCM was used. Nevertheless, random effect estimates, regression coefficients, and standard error estimates were consistent with those from the true MLGCM when the design-based LGCM included the higher-level predictor. They discussed implication for the study with empirical data illustration.     

Specification Search for Identifying the Correct Mean Trajectory in Polynomial Latent Growth Models

This study investigated the optimal strategy for model specification search under the latent growth modeling (LGM) framework, specifically on searching for the correct polynomial mean or average growth model when there is no a priori hypothesized model in the absence of theory. In this simulation study, the effectiveness of different starting models on the search of the true mean growth model was investigated in terms of the mean and within-subject variance-covariance (V-C) structure model. The results showed that specifying the most complex (i.e., unstructured) within-subject V-C structure with the use of LRT, ΔAIC, and ΔBIC achieved the highest recovery rate (>85%) of the true mean trajectory. Implications of the findings and limitations are discussed.     

A Unified Latent Growth Curve Model

Applying item response theory models to repeated observations has demonstrated great promise in developmental research. By allowing the researcher to take account of the characteristics of both item response and measurement error in longitudinal trajectory analysis, it improves the reliability and validity of latent growth curve analysis. This has enabled the study, to differentially weigh individual items and examine developmental stability and change over time, to propose a comprehensive modeling framework, combining a measurement model with a structural model. Despite a large number of components requiring attention, this study focuses on model formulation, evaluates the performance of the estimators of model parameters, incorporates prior knowledge from Bayesian analysis, and applies the model using an illustrative example. It is hoped that this fundamental study can demonstrate the breadth of this unified latent growth curve model.     

Sensitivity Analysis of the No-Omitted Confounder Assumption in Latent Growth Curve Mediation Models

Latent growth curve mediation models are increasingly used to assess mechanisms of behavior change. For latent growth mediation model, like any another mediation model, even with random treatment assignment, a critical but untestable assumption for valid and unbiased estimates of the indirect effects is that there should be no omitted variable that confounds indirect effects. One way to address this untestable assumption is to conduct sensitivity analysis to assess whether the inference about an indirect effect would change under varying degrees of confounding bias. We developed a sensitivity analysis technique for a latent growth curve mediation model. We compute the biasing effect of confounding on point and confidence interval estimates of the indirect effects in a structural equation modeling framework. We illustrate sensitivity plots to visualize the effects of confounding on each indirect effect and present an empirical example to illustrate the application of the sensitivity analysis.     

Predictions of Individual Change Recovered With Latent Class or Random Coefficient Growth Models

Popular longitudinal models allow for prediction of growth trajectories in alternative ways. In latent class growth models (LCGMs), person-level covariates predict membership in discrete latent classes that each holistically define an entire trajectory of change (e.g., a high-stable class vs. late-onset class vs. moderate-desisting class). In random coefficient growth models (RCGMs, also known as latent curve models), however, person-level covariates separately predict continuously distributed latent growth factors (e.g., an intercept vs. slope factor). This article first explains how complex and nonlinear interactions between predictors and time are recovered in different ways via LCGM versus RCGM specifications. Then a simulation comparison illustrates that, aside from some modest efficiency differences, such predictor relationships can be recovered approximately equally well by either model—regardless of which model generated the data. Our results also provide an empirical rationale for integrating findings about prediction of individual change across LCGMs and RCGMs in practice.     

Proportionality Assumption in Latent Basis Curve Models: A Cautionary Note

Latent basis curve models (LBCMs) have been popular in modeling change when the change trajectories are unknown or nonlinear. The estimated change trajectories from LBCMs are often viewed as optimal and used as reference points against which other change trajectories are tested. However, there is a proportionality assumption underlying LBCMs that has received little attention from researchers. This study uses a Monte Carlo simulation to show that violation of this assumption can potentially result in substantially biased estimates of the means and variances of changes and covariate effects on these changes, leading to incorrect statistical inference. The implications of the simulation study are discussed and alternatives to LBCMs are suggested for use when the proportionality assumption is likely to be violated.     

Using Instrumental Variables to Estimate the Parameters in Unconditional and Conditional Second-Order Latent Growth Models

This article applies Bollen’s (1996) 2-stage least squares/instrumental variables (2SLS/IV) approach for estimating the parameters in an unconditional and a conditional second-order latent growth model (LGM). First, the 2SLS/IV approach for the estimation of the means and the path coefficients in a second-order LGM is derived. An empirical example is then used to show that 2SLS/IV yields estimates that are similar to maximum likelihood (ML) in the estimation of a conditional second-order LGM. Three subsequent simulation studies are then presented to show that the new approach is as accurate as ML and that it is more robust against misspecifications of the growth trajectory than ML. Together, these results suggest that 2SLS/IV should be considered as an alternative to the commonly applied ML estimator.     

The Effect of Sampling-Time Variation on Latent Growth Curve Models

Longitudinal data are often collected in waves in which a participant’s data can be collected at different times within each wave, resulting in sampling-time variation that is unaccounted for when waves are treated as single time points. Little research has been reported on the effects of this temporal imprecision on longitudinal growth-curve modeling. This article describes the results of a simulation study into the effect of sampling-time variation on parameter estimation, model fit, and model comparison with an empirical validation of the model fit and comparison results.     

Time-Varying Effect Sizes for Quadratic Growth Models in Multilevel and Latent Growth Modeling

Multilevel and latent growth modeling analysis (GMA) is often used to compare independent groups in linear random slopes of outcomes over time, particularly in randomized controlled trials. The unstandardized coefficient for the effect of group on the slope from a linear GMA can be transformed into a model-estimated effect size for the group difference at the end of a study. Because effect sizes vary nonlinearly in quadratic GMA, the effect size at the end of a study using quadratic GMA cannot be derived from a single coefficient, and cannot be used to estimate effect sizes at intermediate time points with backward extrapolation. This article formulates equations and associated input commands in Mplus for time-varying effect sizes for quadratic GMA. Illustrative analyses that produced these time-varying effect sizes were presented, and a Monte Carlo study found that bias in the effect sizes and their confidence intervals was ignorable.