Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma

INTRODUCTION Bronchioloalveolar carcinoma (BAC) is a par-ticular subtype of pulmonary adenocarcinoma de-rived from clara cell and type II pneumocyte. BAC cells grow along and within alveolar spaces while the alveolar framework of the lung is preserved. The incidence of BAC appears to be rising recently. The etiology and pathogenesis of this unique neoplastic disease are still unclear; many studies of oncogene and tumor suppressor gene expression include BAC with all adenocarcinoma o…     

Parameter selection of pocket extraction algorithm using interaction interface

INTRODUCTION Being the bio era, a significant research effort has been devoted to the study of proteins since they are related to the critical body functions. There have been many studies on proteins, with the voluminous related data being currently available in various pub- lic repositories including the Protein Data Bank (PDB) (CATH, 2006; DALI, 2006; MSD, 2006; RCSB PDB, 2006; SCOP Database, 2006). Given the atomic complexes of proteins, ana- lyzing interactions between them…     

Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury

Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis(SAP) in mul-tiple organ injury is a hotspot in the surgical field.In clinical practice,the main complicated organ dysfunctions are shock,res-piratory failure,renal failure,encephalopathy,with the rate of hepatic diseases being closely next to them.The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis,but also develop into hepatic failure and cause patient death.Its complicated pathogenic mechanism is an obstacle in clinical treatment.Among many pathogenic factors,the changes of vasoac-tive substances,participation of inflammatory mediators as well as OFR(oxygen free radical),endotoxin,etc.may play important roles in its progression.     

Review： Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury

Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis （SAP） in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death, lts complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes of vasoactive substances, participation of inflammatory mediators as well as OFR （oxygen free radical）, endotoxin, etc. may play important roles in its progression.     

Exploration into the Emphases and Sports Difficulties

Through utilizing the relative literature materials, compilation emphases of college Street Dance textbook are “issues related to street dance groups”and“street dance practice content”. The compilation difficulties are:the scientific and effective characters of col ection and col ation of street dance information, content choice of street dance practice, combination of street dance theory and practice, many issues in reality.     

Simulation and Reasonable Design of Bridge Steel Fenders to Reduce Ship Impacts

Steel fenders are increasingly used for ship-impact resistance structures in the design of navigable bridges. As an important approach to investigating this anti-impact structure effectiveness to reduce influences of vessel impact, simulation analyses are still not perfect yet. So this paper is intended to discuss several issues related to ship collision simulations, including steel constitutive relationship, connections between steel box and pile cap, contacts definition and friction consideration, and the determination of impact waterlines and angles. Consequently based on two examples of ship-steel fender-bridge structure systems, some conclusions about effectiveness and design of fenders to reduce ship impact are drawn.     

The Application of Noticing Theory to English Writing Teaching and Learning in China

“Noticing”is emphasized for its great influence on second language learning. Based on the previous related studies,this paper attempts to apply noticing theory to English writing teaching and learning in China by means of the enlargement of input,the implement of output-oriented activities and the focus on feedback.     

On Helping Non-Major English Postgraduates Achieve More in English Listening

In this article,the writer aims at emphasizing the significance of English listening in postgraduates’English Language Teaching and English Language Learning.The writer tries to solve the problems related to postgraduates’English listening and improve their Listening ability by providing many practical issues,effective strategies and different managing approaches.     

Current status,enablers ＆ barriers of implementing cellular manufacturing system in Indian industries

The cellular manufacturing （CM） has been proved as a well-known manufacturing strategy that helps to improve manufacturing efficiency and productivity by utilizing the philosophy of group technology. Large num- ber of papers has been published in the area of design issues of CM system. Unfortunately, the issues related to acceptability of CM in Indian industries are typically not examined rigorously as technical issues. This paper pre- sents the results of a survey carded out to find the status, enabler and barrier of implementing CM system in Indian industries.     

Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. In this review, we highlight the multiple functions of hydrogen and the mechanisms underlying its protective effects in various lung diseases, with a focus on its roles in disease pathogenesis and clinical significance.     

Lung surfactant

Lung surfactant, a lipo-protein complex, is a highly surface-active material found in the fluid lining the air-liquid interface of the alveolar surface. Surfactant plays a dual function of preventing alveolar collapse during breathing cycle and protection of the lungs from injuries and infections caused by foreign bodies and pathogens. Varying degrees of structure-function abnormalities of surfactant have been associated with obstructive lung diseases, respiratory infections, respiratory distress syndromes, interstitial lung diseases, pulmonary alveolar proteinosis, cardiopulmonary bypass surgery and smoking. For some pulmonary conditions, especially respiratory distress syndrome, surfactant therapy is on the horizon.     

Bridging the performance gap with ergonomics: A case study

Faced with increased incidences of work‐related strain and sprain injuries and OSHA‐recordable injuries, the organization in this case study details how it resolved these performance‐related issues. This case study also demonstrates the effectiveness of Thomas Gilbert's (1978) Behavior Engineering Model as a tool for analyzing, defining, and resolving performance issues.     

外伤性迟发性结肠破裂21例分析

目的:探讨外伤性迟发性结肠破裂的临床特征、诊断和治疗方法,提高早期确诊率和治疗疗效。方法:对21例结肠损伤患者的临床资料进行回顾性分析。结果:全组患者均行二期手术治愈。6例患者术后切口感染,4例肠粘连。无造瘘术后肠梗阻、造瘘口狭窄及切口疝等并发症。结论:二期手术适用于严重的休克,全身状态不佳,腹内多脏器损伤和严重的感染。治疗外伤性迟发性结肠破裂重要的是准确判断结肠损伤程度和范围,了解合并损伤的脏器,术中仔细探查,彻底进行肠道和腹腔冲洗,并严格清创和消毒。     

Developmental dyslexia,neurolinguistic theory and deviations in brain morphology

Although some form of central nervous system involvement is presumed, evidence establishing a relationship between dyslexia and neurological dysfunction has been correlational. Recently, neuroimaging and postmortem studies have begun to provide direct evidence implicating neuropathological structures in dyslexia. This article reviews computed tomography (CT) and magnetic resonance imaging (MRI) studies examining deviations in brain morphology which appear to be associated with neurolinguistic functioning. Methodological and technical issues are discussed. Based on their own and others research, the authors conclude that dyslexics show variations in specific brain regions, namely, reversed or symmetrical plana temporale (LR), smaller insular length bilaterally, and symmetrical frontal regions. Moreover, recent studies by the senior author and colleagues suggest that specific reading tasks are associated with specific variations in brain morphology. Symmetrical frontal widths was related to poorer passage comprehension, and reversed frontal area symmetry was related to poor word attack skills. Though many conceptual and technical issues remain unresolved, neuroimaging procedures appear to provide direct evidence supporting the importance of deviations in normal patterns of brain morphology in dyslexia.     

Elementary Pre-Service Teacher Perceptions of the Greenhouse Effect

Environmental issues are an important topic both in national news, and in science education. Previous studies revealed that students hold many misconceptions relating to such issues as global warming, ozone depletion, and acid rain. This article expands on earlier work by Boyes et al. to examine pre-service teachers' views about these issues, especially global warming and the related term, the greenhouse effect, and the effect of their views on elementary student performance. Results support the findings of Boyes et al. that elementary education majors hold many misconceptions about these environmental issues, and these can effect their teaching of these topics in elementary classes.     

Induced pluripotent stem cells: origins, applications, and future perspectives

Embryonic stem(ES)cells are widely used for different purposes,including gene targeting,cell therapy,tissue repair,organ regeneration,and so on.However,studies and applications of ES cells are hindered by ethical issues regarding cell sources.To circumvent ethical disputes,great efforts have been taken to generate ES cell-like cells,which are not derived from the inner cell mass of blastocyst-stage embryos.In 2006,Yamanaka et al.first reprogrammed mouse embryonic fibroblasts into ES cell-like cells called induced pluripotent stem(iPS)cells.About one year later,Yamanaka et al.and Thomson et al.independently reprogrammed human somatic cells into iPS cells.Since the first generation of iPS cells,they have now been derived from quite a few different kinds of cell types.In particular,the use of peripheral blood facilitates research on iPS cells because of safety,easy availability,and plenty of cell sources.Now iPS cells have been used for cell therapy,disease modeling,and drug discovery.In this review,we describe the generations,applications,potential issues,and future perspectives of iPS cells.     

A Primer on College Student Substance Use Disorders Screening,Assessment, and Treatment Planning

Significant numbers of college students experience negative consequences due to their misuse of alcohol and other drugs. For far too many, some of these effects are ruinous of their lives, and for well more than a thousand each year, life ending. This article first provides an overview of the scope of this problem. It then covers both assessment and intervention starting with brief and standard assessment inventories followed by a perspective on comprehensive focused counseling that incorporates an assessment of multiple life areas. A case is made that many students have substance use disorders issues either as primary problems or auxiliary to other concerns. Treatment planning based on a comprehensive approach to change, and the role of ongoing utilization of change measures, is then discussed. A basic premise of the article is that due to a lack of education, training, and exposure, many college mental health practitioners underdiagnose and underattend to the presence of substance use disorders problems. Many clinical staff members have never taken an academic course focused on this treatment issue or have done little by way of continuing education on this topic, so they may lack the knowledge, skills, and aptitudes related to the provision of helpful comprehensive care and consequently make the error of focusing exclusively on the substance use disorders related behaviors.     

The Hypocrisy of Amateurism

Sport and recreational activity is a vital part of today's society, and athletic training researchers are playing an important role in gaining a better understanding of how to promote safe and healthy participation for athletes of all ages. This article aims to illustrate the importance of research to prevent and effectively treat sport and recreational injuries. Increased physical activity among Americans is helping to combat chronic diseases such as obesity and diabetes, but injuries related to increased activity are on the rise. We must be responsible in our approach to promoting physical activity and participation in sport, while minimizing risk of injury. Athletic training researchers and colleagues from other disciplines within kinesiology, allied health sciences, and medicine must work collaboratively to identify predispositions to athletic injuries and illnesses. They must further conduct prospective studies that will help clinicians better manage these injuries and prevent their recurrence. This article highlights the progress that athletic training researchers have made to bridge the gap between research and clinical practice.     

当前农村流动儿童的教育政策研究及其建议

随着中央对“三农”问题的日益重视以及我国城镇化和产业化进程的不断加快,与农民工这一群体相关的问题日益受到政府、学者的关注,其中包括流动儿童教育问题。针对1995年至2006年间国家相继出台的关于流动儿童教育政策以及在“两为主”原则的教育政策下,分析流动儿童在政策层面下存在的问题及其原因,并为完善教育政策提出有益的建议．